Test Price
2,800 AED✅ Home Collection Available
POLG Gene Mitochondrial DNA Depletion Syndrome Type 4A Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين POLG لمتلازمة استنفاد الحمض النووي للميتوكوندريا من النوع 4A في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection & VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
خدمة تشخيصية دقيقة ومعتمدة وفق قوانين الرعاية الصحية في الإمارات، مع ضمان خصوصية البيانات الجينية وكامل الالتزام بمرسوم القانون الاتحادي رقم 41 لسنة 2024.
Overview
The POLG gene test uses Next-Generation Sequencing (NGS) to detect pathogenic variants causing mitochondrial DNA depletion syndrome type 4A (Alpers-Huttenlocher syndrome). Our UAE facility delivers definitive results within 3–4 weeks, fully aligned with DHA/MOHAP standards.
يُتيح هذا الاختبار تشخيص متلازمة استنفاد الحمض النووي للميتوكوندريا من النوع 4A بدقة عالية عبر تسلسل الجيل التالي، مع التزام كامل بمعايير هيئة الصحة بدبي.
| Feature | Our Test (POLG NGS – UAE) | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity | ~95% – Misses deep intronic & copy‑number variants |
| Methodology | NGS Full Gene Sequencing + Deletion/Duplication Analysis | Exon‑by‑exon Sanger Sequencing |
| Turnaround | 3–4 Weeks (ISO‑Led Precision) | 6–8 Weeks |
| DHA Compliance | Full DHA/MOHAP Standard & UAE PDPL | Variable |
Physician Insight & Safety Protocol
“As a consultant neurologist managing mitochondrial disorders, I emphasize that a positive POLG result must be correlated with clinical and biochemical findings—not all variants are pathogenic. Genetic counselling is critical to interpret results and plan family screening. Please continue all prescribed treatments unless otherwise directed by your specialist.”
– Dr. PRABHAKAR REDDY, DHA Licence 61713011
⚠️ Medication Warning:
Do not discontinue prescribed medication without consulting your doctor. Specifically, the use of valproate (Depakene) is contraindicated in undiagnosed mitochondrial disease due to the risk of fulminant liver failure. Hold valproate until POLG test results are available and discussed with your physician.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Patients with acute liver failure, uncorrected coagulopathy, or haemodynamic instability are not eligible for home draw; hospital-based collection is required.
- After Sampling ER Red Flags: Seek immediate medical attention if you develop acute jaundice, severe abdominal pain, protracted vomiting, new‑onset seizures, or altered consciousness—especially if valproate was recently started.
- Home Collection Limitations: Available only for patients aged 3 years and above with stable vital signs; paediatric cases require specialist consultation prior to booking.
Frequently Asked Questions
1. What is the POLG gene test used for?
This NGS‑based test confirms mitochondrial DNA depletion syndrome type 4A (Alpers‑Huttenlocher), identifies carrier status, and guides familial screening. Early diagnosis prevents exposure to hepatotoxic drugs like valproate.
يُستخدم تحليل جين POLG لتأكيد متلازمة استنفاد الحمض النووي للميتوكوندريا من النوع 4A والكشف عن الحاملين للمرض وتوجيه الفحص العائلي.
2. How long do results take, and what sample is needed?
Results are delivered in 3–4 weeks from a simple blood draw, DNA FTA card, or extracted DNA. Home collection by our phlebotomy team uses cold chain transport to ensure specimen stability.
تظهر النتائج خلال 3-4 أسابيع من سحب عينة دم أو بطاقة FTA أو حمض نووي مستخلص، مع خدمة السحب المنزلي والنقل المبرد.
3. Is genetic counseling required before testing?
Pre‑test genetic counseling is mandatory to draw a pedigree and obtain informed consent, in compliance with Federal Decree‑Law No. 41 of 2024. Post‑ counseling interprets results and guides clinical decisions.
الاستشارة الوراثية قبل الفحص إلزامية لرسم شجرة العائلة والحصول على الموافقة المستنيرة، وفقاً للمرسوم بقانون اتحادي رقم 41 لسنة 2024.
Home collection available 8 AM – 11 PM daily. ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
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التحقق من التغطية التأمينية
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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