Test Price
2,800 AED✅ Home Collection Available
POLG Gene Mitochondrial DNA Depletion Syndrome Type 4A Genetic Test in UAE | 2800 AED | DHA Licensed Lab 1143
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily 8 AM – 11 PM).
- Clinical Guidance: Comprehensive post-test genetic counseling for result interpretation.
- Insurance & Billing: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The POLG gene test utilizes Next-Generation Sequencing (NGS) to detect pathogenic variants responsible for mitochondrial DNA depletion syndrome type 4A (Alpers-Huttenlocher syndrome). This comprehensive analysis includes full gene sequencing and deletion/duplication (CNV) bioinformatics.
Our DHA-licensed laboratory in Dubai Healthcare City delivers definitive results within one month, ensuring full compliance with UAE genomics standards and international clinical guidelines.
| Feature | Our Test (POLG NGS – UAE) | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity | ~95% – Misses deep intronic & copy‑number variants |
| Methodology | NGS Full Gene Sequencing + Deletion/Duplication Analysis | Exon‑by‑exon Sanger Sequencing |
| Turnaround | 3–4 Weeks (ISO‑Led Precision) | 6–8 Weeks |
| DHA Compliance | Full DHA/MOHAP Standard & UAE PDPL 2021 | Variable |
Physician Insight & Safety Protocols
– Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Critical Medication Advisory
Do not discontinue or initiate any prescribed medication without consulting your physician. The use of valproate (Depakene) is strictly contraindicated in undiagnosed or suspected mitochondrial disease due to the high risk of precipitating acute liver failure. Valproate therapy must be held until POLG test results are reviewed by your specialist.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Patients with acute liver failure, uncorrected coagulopathy, or haemodynamic instability are not eligible for home draw; hospital-based collection is required.
- After Sampling Red Flags: Seek immediate medical attention if you develop acute jaundice, severe abdominal pain, protracted vomiting, new-onset seizures, or altered consciousness—especially if valproate was recently initiated.
- Home Collection Limitations: Available only for patients aged 3 years and above with stable vital signs; paediatric cases require specialist consultation prior to booking.
Patient FAQ & Clinical Guidance
1. What is the primary clinical utility of the POLG gene test?
This NGS-based test is the gold standard for confirming mitochondrial DNA depletion syndrome type 4A (Alpers-Huttenlocher syndrome). It is also used to identify carrier status within families and guide critical therapeutic decisions, such as avoiding hepatotoxic medications like valproate.
2. What sample types are accepted, and what is the turnaround time?
The test accepts peripheral whole blood, DNA FTA cards, or extracted DNA. Our ISO 9001:2015 accredited laboratory processes samples with a turnaround time of 3–4 weeks to ensure comprehensive sequencing and deletion/duplication analysis.
3. Is genetic counseling mandatory before and after the test?
Yes. In compliance with UAE's Federal Decree-Law No. 4 of 2016 on Medical Liability and international best practices, pre-test genetic counseling is mandatory to obtain informed consent and draw a detailed pedigree. Post-test counseling is critical for interpreting variant pathogenicity and guiding clinical management.
UAE Regulatory & Data Privacy Adherence
Federal Compliance Framework
Your genetic data is processed under the strictest privacy regulations. DNA Labs UAE fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring the highest standards of patient safety and informed consent.
Clinical & Logistical Metadata
| Test Name | POLG Gene Full Sequencing & Deletion/Duplication Analysis (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood, DNA FTA Card, or Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) + CNV Bioinformatics Analysis |
| ICD-10-CM Code | E88.81 |
| LOINC Code | 101308-6 |
| DHA Facility License & Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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