Test Price
2,800 AED✅ Home Collection Available
NDUFS6 Gene (Mitochondrial Complex I Deficiency) Genetic Test in Dubai | AED 2,800 | DHA Licensed
Executive Summary & Core Metrics
Diagnostic Sensitivity: 99.9% via Next‑Generation Sequencing (NGS)
Full gene coverage including deep intronic and copy number variant analysis under ISO 9001:2015 certified protocols.
Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection
Available daily from 8 AM to 11 PM. All samples are transported under validated cold‑chain conditions.
Post‑Test Guidance: Telephonic Consultation with a DHA‑Licensed Medical Genetics Specialist
Interpretation of the genetic report integrated with clinical, biochemical, and imaging findings.
Insurance & Billing: Direct Verification via WhatsApp at +971 54 548 8731
Pre‑authorization check for in‑network and out‑of‑network plans, including cash and card payments.
Certification: ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | DHA Facility License: 1143 | DNA Labs UAE
Test Overview & Methodology
The NDUFS6 Next‑Generation Sequencing (NGS) test identifies pathogenic variants responsible for mitochondrial complex I deficiency, a severe neurometabolic disorder characterized by progressive neurological decline, Leigh syndrome, and multi‑system involvement. This assay targets the full coding region, intron‑exon boundaries, and select deep intronic regions of the NDUFS6 gene, detecting single nucleotide variants (SNVs), small insertions/deletions (indels), and copy number variants (CNVs). Testing is indicated for symptomatic individuals, at‑risk family members, and prenatal diagnosis under strict UAE regulatory oversight and mandatory pre‑test genetic counselling.
| Feature | DNA Labs UAE NGS Panel | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next‑Generation Sequencing (NGS) – full gene coverage | Single‑gene Sanger sequencing (coding region only) |
| Diagnostic Sensitivity | 99.9% (including intronic and CNV analysis) | ~95% (excludes deep intronic and structural variants) |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Regulatory Compliance | DHA licensed, ISO 9001:2015, UAE PDPL (Law 45/2021) | Variable, often non‑accredited local labs |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I recognize the profound implications a definitive genetic diagnosis carries for families. This NDUFS6 NGS assay offers high‑resolution molecular clarity, yet its results must always be interpreted within the full clinical context—including neurological examination, brain MRI findings, and biochemical markers such as lactate and pyruvate. Genetic findings alone never constitute a standalone diagnosis; they are one component of a comprehensive multidisciplinary assessment. I strongly encourage all families to participate in pre‑test counselling and post‑test consultation with a qualified genetics professional.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠️ Medication Safety Notice
Do not discontinue, alter, or adjust any prescribed medications—including vitamins, supplements, or metabolic therapies—based solely on genetic test results. Treatment decisions must be made collaboratively with your treating physician and metabolic specialist following full clinical correlation.
Patient Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: This test is not a standalone emergency diagnostic tool. It must be preceded by a formal genetics consultation and written informed consent. Acute intercurrent illness (e.g., severe infection, metabolic decompensation) may require delaying sample collection until clinical stability is achieved. Patients with uncontrolled seizures or acute respiratory distress should not undergo phlebotomy until stabilized.
- Emergency Red Flags: If the patient (infant, child, or adult) develops acute metabolic crisis, refractory seizures, severe lactic acidosis, progressive encephalopathy, or unexplained respiratory distress, seek immediate emergency department care—do not delay management while awaiting genetic results.
Patient FAQ & Clinical Guidance
1. What is the NDUFS6 gene test, and why is it performed?
Short Answer: The NDUFS6 gene test uses next‑generation sequencing to detect mutations that cause mitochondrial complex I deficiency, a severe neurological and metabolic disorder affecting energy production in cells.
This NGS‑based assay examines the full coding region of the NDUFS6 gene, including exon‑intron boundaries, to identify single nucleotide variants, small insertions/deletions, and copy number changes. It is primarily ordered when clinical features (e.g., Leigh syndrome, leukoencephalopathy, developmental regression, or hypotonia) and biochemical evidence (elevated lactate, abnormal respiratory chain enzyme activity) point to mitochondrial dysfunction. A pre‑test genetic counselling session is mandatory to construct a three‑generation pedigree, discuss autosomal recessive inheritance, and document informed consent.
2. How accurate is this genetic test, and what is the turnaround time?
Short Answer: With a diagnostic sensitivity of 99.9% and ISO 9001:2015 certification, results are delivered within 3 to 4 weeks from sample receipt.
The high sensitivity is achieved through deep‑coverage NGS and bioinformatic pipelines validated under ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139). Every clinically significant variant is confirmed by orthogonal methods such as Sanger sequencing or multiplex ligation‑dependent probe amplification (MLPA) as needed. The laboratory strictly adheres to UAE Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL), and all patient data is processed solely for diagnostic purposes. A telephonic post‑test consultation with a DHA‑licenced medical genetics specialist is included to help interpret the report and guide next steps.
3. Do I need a doctor’s referral or genetic counselling before the test?
Short Answer: Yes, pre‑test genetic counselling conducted by a registered genetic counsellor or clinical geneticist is mandatory. A formal referral from a treating neurologist, paediatrician, or metabolic physician is strongly recommended.
Under the UAE Federal Law framework governing genetic testing and clinical responsibility (including Federal Decree‑Law No. 4 of 2016 on Medical Liability), a formal genetics consultation must precede testing to ensure the patient (or legal guardian) understands the scope, limitations, possible incidental findings, and implications for family members. The session includes a detailed three‑generation pedigree and discussions on reproductive options. Our team can arrange this tele‑consultation with a DHA‑registered genetics professional. The test is not offered to minors without explicit parental consent and legal compliance with UAE child data protection standards under PDPL 2021. Referral documentation and insurance eligibility are verified before scheduling any sample collection.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE complies fully with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access‑controlled, and processed solely for the specified diagnostic purpose. Patient data is never shared with third parties without explicit written consent. Our DHA‑licensed facility (License No. 1143) at Dubai Healthcare City undergoes regular audits to maintain compliance with UAE data privacy and health information security standards.
Clinical & Logistical Metadata
| Test Name | NDUFS6 Gene (Mitochondrial Complex I Deficiency) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole Blood (Peripheral Blood) – EDTA tube standard |
| Methodology Used | Next‑Generation Sequencing (NGS) |
| ICD-10-CM Code | E88.49 |
| LOINC Code | 94228-7 |
| DHA Facility License & Lab Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
For booking and insurance verification, contact us via WhatsApp at +971 54 548 8731. VIP home phlebotomy operates daily from 8:00 AM to 11:00 PM. All samples are transported under validated cold‑chain protocols in compliance with DHA health logistics standards.
Prices are inclusive of mandatory pre‑test genetic counselling and post‑test clinical guidance. This page is reviewed quarterly by our clinical advisory board.
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