Test Price
2,800 AEDโ Home Collection Available
NDUFAF3 Gene Mitochondrial Complex I Deficiency NGS Test | Accurate Genetic Analysis in UAE
Executive Summary & Core Metrics
- Diagnostic Precision: 99.9% analytical sensitivity via ISO 9001:2015 certified laboratory processing with full gene sequencing and CNV detection.
- VIP Logistics: Temperature-controlled cold-chain home phlebotomy available daily from 8 AM to 11 PM across all UAE emirates.
- Clinical Guidance: Post-test telephone consultation with a consultant medical geneticist for result interpretation and family risk assessment.
- Insurance Support: Direct verification and booking assistance via WhatsApp at +971545488731.
Test Overview & Methodology
The NDUFAF3 gene test detects pathogenic variants linked to mitochondrial Complex I deficiency, a severe neurometabolic disorder with multisystem involvement. Our NGS methodology delivers comprehensive coverage of the entire coding region and intron-exon boundaries, enabling detection of single nucleotide variants, small insertions and deletions, and copy number alterations. This ensures clinically actionable insights for precise diagnosis, prognosis estimation, and recurrence risk counseling.
| Feature | Our NDUFAF3 NGS Test | Standard Mitochondrial Panel |
|---|---|---|
| Precision | Full gene sequencing + CNV analysis; 99.9% analytical sensitivity with validated bioinformatics | Often limited to hotspot regions, missing regulatory and copy number variants |
| Methodology | NGS with proprietary bioinformatics pipeline, validated per ACMG guidelines and ISO 9001:2015 | PCR-based or smaller gene panels without comprehensive NDUFAF3 exon coverage |
| Speed | 3โ4 weeks with expedited reporting available for critically ill neonates and acute presentations | 4โ6 weeks, often without dedicated clinical interpretation support |
Physician Insight & Safety Protocols
"As a Consultant Medical Geneticist, I emphasize that genetic test results represent one component of a comprehensive diagnostic evaluation. The NDUFAF3 test provides critical information regarding mitochondrial Complex I deficiency, but these findings must be interpreted alongside neurological examination, family pedigree analysis, metabolic laboratory data, and neuroimaging. I strongly advise against making any clinical decisions based solely on a genetic report. Always discuss the implications with your treating neurologist and a certified genetic counselor."
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory
Do not discontinue or modify any prescribed medication, vitamin, or metabolic supplement without direct consultation with your treating physician. This diagnostic test does not replace ongoing clinical management or established therapeutic plans.
Safety Exclusion Criteria & Emergency Red Flags
- Patients with severe coagulopathy or active uncontrolled seizure disorders must not undergo home phlebotomy without prior clearance from their primary neurologist.
- Minors under 18 years require documented parental or guardian consent in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability; unaccompanied minors will be rescheduled.
- If you experience acute neurological deterioration, respiratory distress, metabolic crisis, or loss of consciousness, seek emergency care immediately or dial 998. Do not delay emergency management while awaiting genetic test results.
Patient FAQ & Clinical Guidance
1. What does the NDUFAF3 genetic test check for?
Answer: This test identifies DNA sequence variants and copy number changes in the NDUFAF3 gene that cause mitochondrial Complex I deficiency. It enables precise molecular diagnosis, prognosis estimation, and recurrence risk counseling for affected families, guiding both clinical management and family planning decisions.
2. Who should consider taking this test in the UAE?
Answer: Individuals with unexplained neurological symptoms such as progressive muscle weakness, developmental regression, Leigh-like features, optic atrophy, cardiomyopathy, or a family history of mitochondrial disease should seek referral from a neurologist or medical geneticist. Early genetic confirmation can guide metabolic management and therapeutic options.
3. How should I prepare for the blood collection, and is fasting required?
Answer: No special preparation or fasting is needed. Remain well-hydrated and bring a complete list of current medications, supplements, and any prior genetic test reports to your home collection appointment to ensure accurate clinical correlation of results.
UAE Regulatory & Data Privacy Adherence
This laboratory service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is processed under ISO 9001:2015 certification (Certificate No. INT/EGQ/2509DA/3139) with strict confidentiality, encryption, and access control measures. Sample collection, storage, and reporting adhere to the highest standards of clinical safety and data protection as mandated by UAE healthcare regulations.
Clinical & Logistical Metadata
| Test Name | NDUFAF3 Gene Mitochondrial Complex I Deficiency NGS Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 weeks (expedited reporting available for critically ill neonates and urgent clinical indications) |
| Sample Type / Matrix | Peripheral whole blood (VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM) |
| Methodology Used | Next-Generation Sequencing (NGS) with full coding region coverage, intron-exon boundary analysis, and CNV detection |
| ICD-10-CM Code | E88.49 |
| LOINC Code | 94041-6 |
| DHA Facility License & Laboratory Address | DHA Facility License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
Contact us on WhatsApp +971545488731 for insurance verification, booking, or clinical inquiries. Our DHA-licensed team is available from 8 AM to 11 PM daily.
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All reports reviewed by DHA-Certified physicians