Test Price
2,800 AED✅ Home Collection Available
MT‑TV Gene (Leigh Syndrome) Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
TRUST 99.9% Diagnostic Sensitivity via ISO‑Accredited NGS
PREMIUM LOGISTICS VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM)
CLINICAL GUIDANCE Telephonic Post-Test Expert Result Interpretation by Consultant Medical Geneticist
INSURANCE Direct Billing Check via WhatsApp +971 54 548 8731
Executive Summary
A definitive molecular diagnostic assay utilizing Next-Generation Sequencing to detect pathogenic variants in the MT-TV gene associated with Leigh Syndrome. This test provides a precise genetic etiology crucial for clinical management, prognostic evaluation, and informed family planning. Results are interpreted and delivered under the direct supervision of our Consultant Medical Geneticist, ensuring alignment with UAE healthcare regulatory standards.
Test Overview & Methodology
This advanced genetic test thoroughly analyzes the MT-TV mitochondrial gene responsible for Leigh Syndrome, a severe neonatal neurological disorder. By identifying pathogenic variants with high precision, the test provides a definitive molecular diagnosis that is critical for clinical management, genetic counseling, and family planning. Our validated NGS workflow ensures comprehensive coverage and high analytical sensitivity.
| Feature | Our Test (MT-TV NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity; detects all mutation types (SNVs, indels, and large deletions) | ~95% for targeted regions; may miss large deletions or duplications |
| Methodology | Next‑Generation Sequencing (NGS) with full MT-TV gene coverage and high depth of read | Sanger Sequencing of selected exons only |
| Turnaround Time | 14 – 21 Business Days (express options available upon request) | 21 – 35 Business Days |
Physician Insight & Safety Protocols
"As a Consultant Medical Geneticist, I recognize the profound clinical and emotional implications of confirming a diagnosis of Leigh Syndrome. The MT-TV NGS assay provides a robust molecular cornerstone for genetic counseling, yet it is imperative that results are contextualized within the full clinical picture, including neuroimaging and biochemical data. This test empowers families with definitive answers, guiding critical care decisions and recurrence risk assessment."
— Ms. Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication & Clinical Warning
Do not discontinue any prescribed medication or alter treatment plans without consulting your supervising physician. This genetic test is a diagnostic adjunct, not a replacement for ongoing critical care or emergency intervention. All clinical decisions must be made in consultation with a qualified healthcare provider.
Exclusion Criteria & Emergency Red Flags
- Acute hemodynamic instability, respiratory failure, or uncontrolled seizures – priority is immediate emergency care, not sample collection.
- Minors without valid legal guardian consent (per UAE Federal Laws on Medical Liability and Personal Data Protection).
- Insufficient sample volume: whole blood (≤1 mL), extracted DNA (<200 ng), or damaged FTA card.
- If the patient exhibits sudden neurological deterioration (loss of consciousness, abnormal muscle tone, seizures), seek emergency medical assistance without delay.
Patient FAQ & Clinical Guidance
1. What is the MT-TV gene test and why is it performed?
This advanced test uses Next-Generation Sequencing to detect pathogenic mutations in the MT-TV gene that cause Leigh Syndrome, a severe mitochondrial condition leading to progressive neurological decline. It is ordered when clinical features such as psychomotor regression, brainstem lesions on MRI, or family history suggest a mitochondrial disorder. Carrier screening may also be offered to at-risk relatives following a positive result.
2. How is the sample collected and what are the requirements for a child?
A simple blood draw, buccal swab, or a few drops on an FTA card is sufficient. Our pediatric-trained phlebotomists perform neonatal home collection ensuring minimal discomfort and strict cold-chain transport. For a child, a single drop of whole blood or a buccal swab may be used after obtaining informed parental consent as mandated by UAE regulatory frameworks.
3. What do the results mean and how quickly will I receive them?
Results are typically ready within 14 to 21 business days and will indicate whether a disease-causing MT-TV variant was detected. A negative result greatly reduces the likelihood of Leigh Syndrome but does not eliminate all genetic risks. Our Consultant Medical Geneticist will explain the findings and recommend follow-up steps, including carrier testing for family members if a mutation is identified.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Legal Compliance
This service strictly adheres to the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical procedures are conducted in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability. Our laboratory is accredited to ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139). Direct billing verification and legal queries can be directed via WhatsApp at +971 54 548 8731.
Clinical & Logistical Metadata
| Test Name | MT-TV Gene (Leigh Syndrome) Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 14 – 21 Business Days |
| Sample Type / Matrix | Whole Blood (EDTA), Buccal Swab, or Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) with Full MT-TV Gene Coverage |
| ICD-10-CM Code | G31.81, E88.40 |
| LOINC Code | 101350-8 |
| DHA License & Lab Address | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DHA License 1143 |
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