Test Price
2,800 AEDโ Home Collection Available
MTFMT Gene Combined Oxidative Phosphorylation Deficiency Type 15 Genetic Test | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- โ Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited NGS processing (Cert: INT/EGQ/2509DA/3139).
- โ Premium Logistics: VIP Mobile Phlebotomy & temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- โ Clinical Guidance: Telephonic post-test interpretation by senior consultant medical geneticist.
- โ Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The MTFMT Gene Combined Oxidative Phosphorylation Deficiency Type 15 Genetic Test is a comprehensive next-generation sequencing analysis that identifies pathogenic variants in the MTFMT gene, responsible for a severe mitochondrial disorder. This test provides definitive molecular diagnosis for affected individuals and carrier screening for at-risk family members, guiding clinical management and genetic counselling.
| Feature | Our Test (MTFMT NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Coverage | Full gene: all exons, splice sites, deep intronic regions | Select exons only, may miss deep variants |
| Sensitivity | >99% for single nucleotide variants and small indels | ~95% for targeted regions |
| Turnaround Time | 3-4 weeks | 2-3 weeks |
| Bioinformatics & Interpretation | ACMG-guided variant classification, comprehensive clinical report | Basic report, limited interpretation |
| Regulatory Compliance | ISO 9001:2015, DHA/MOHAP standards | Not always ISO certified |
Physician Insight & Safety Protocols
โAs a consultant in medical genetics, I want to emphasise that while this NGS test provides exceptional sensitivity for detecting MTFMT mutations, a negative result does not eliminate the possibility of other mitochondrial disorders. All genetic findings must be carefully integrated with the patientโs complete clinical and biochemical presentation.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
โ ๏ธ Do not discontinue any prescribed medication or supplement regimen without consulting your treating physician. This genetic test is for diagnostic purposes only and does not replace ongoing clinical care.
Safety Exclusion Criteria & ER Red Flags
- Exclusion Criteria: Patients currently experiencing acute metabolic decompensation (e.g., severe acidosis, hyperammonemia) or unstable clinical status are not suitable for home blood collection. Immediate hospital-based emergency care is required.
- Emergency Red Flags: If the patient develops lethargy, intractable vomiting, seizures, loss of consciousness, or respiratory distress, seek emergency medical attention immediately. Do not delay care while awaiting test results.
- Minors must be accompanied by a parent or legal guardian and require prior genetic counselling before sample collection, in compliance with UAE child protection regulations.
Patient FAQ & Clinical Guidance
1. What is the MTFMT gene test and why is it performed?
The MTFMT NGS test sequences the entire MTFMT gene to detect mutations that cause combined oxidative phosphorylation deficiency type 15, a rare mitochondrial disease. This test is indicated for patients presenting with hypotonia, developmental delay, lactic acidosis, and multi-organ involvement. Identifying a pathogenic variant enables accurate diagnosis, informs prognosis, and guides family planning and genetic counselling for at-risk relatives.
2. How is the test performed and when will I receive the results?
A simple venous blood sample is collected via our VIP Mobile Phlebotomy service using temperature-controlled cold-chain transport. The extracted DNA undergoes high-depth next-generation sequencing, with results delivered within 3-4 weeks. Once analysis is complete, a comprehensive clinical report is prepared and reviewed by our consultant medical geneticist, followed by a telephonic guidance session to help you understand the findings.
3. Is the genetic test covered by health insurance in the UAE?
We offer direct insurance billing verification via WhatsApp at +971 54 548 8731 to confirm coverage for mitochondrial genetic testing based on your policy. Coverage depends on your plan and clinical necessity. Our team coordinates with all major UAE insurers including Daman, AXA, and Oman Insurance to facilitate prior approval. You will be informed of any co-payments before the test is performed.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Legal Compliance
This service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is processed under strict confidentiality protocols. Clinical safety and patient consent governance follows Federal Decree-Law No. 4 of 2016 on Medical Liability. Facility license 1143 issued by Dubai Health Authority.
Clinical & Logistical Metadata
| Test Name | MTFMT Gene Combined Oxidative Phosphorylation Deficiency Type 15 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3-4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood or Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | E88.49 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | License 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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