Test Price
2,800 AED✅ Home Collection Available
MT-TN Gene Sequencing for Mitochondrial Complex I Deficiency – Genetic Test in Dubai, UAE
Executive Summary & Core Metrics
🔬 Diagnostic Sensitivity: 99.9% via ISO 9001:2015 Certified Next‑Generation Sequencing (NGS) on Illumina NovaSeq platform
🚗 Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (Available daily 8 AM–11 PM)
🧑⚕️ Post‑Test Guidance: Complimentary telephonic genetic counselling session for result interpretation and family cascade screening
💳 Insurance & Billing: Direct billing verification via WhatsApp at +971 54 548 8731
⏱ Turnaround Time: 3–4 weeks from sample receipt to final clinical report
📋 Test Price: 2,800 AED (inclusive of phlebotomy, sequencing, bioinformatic analysis, and counselling)
Test Overview & Methodology
The MT‑TN gene encodes a transfer RNA essential for mitochondrial protein translation. Pathogenic variants in MT‑TN disrupt assembly of mitochondrial complex I (NADH:ubiquinone oxidoreductase), leading to a spectrum of neurometabolic disorders including Leigh syndrome, encephalopathy, hypertrophic cardiomyopathy, and myopathy. This targeted NGS test interrogates the full mitochondrial genome with deep coverage of the MT‑TN locus, enabling detection of heteroplasmic variants at allele frequencies as low as 5%. Definitive molecular diagnosis supports early intervention, prognostic stratification, and informed reproductive counselling.
| Feature | DNA Labs UAE – MT‑TN NGS Test | Alternative Approach (Sanger Sequencing) |
|---|---|---|
| Genomic Coverage | Whole mitochondrial genome with ≥1000× depth; heteroplasmy detection down to 5% | Targeted exon‑only; may miss deep intronic or heteroplasmic variants |
| Methodology | Next‑Generation Sequencing (Illumina NovaSeq 6000) with dual‑index library preparation and GATK bioinformatic pipeline | Capillary electrophoresis; low throughput, single‑reaction per amplicon |
| Turnaround Time | 3–4 weeks | 6–8 weeks (multiple sequential reactions required) |
| Variant Classification | ACMG/AMP guidelines; ClinVar and MITOMAP cross‑referenced | Manual interpretation; limited population frequency data |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I underscore that MT‑TN variants demonstrate heteroplasmic inheritance with tissue‑specific threshold effects. A positive molecular finding confirms mitochondrial complex I deficiency, but clinical severity correlates poorly with heteroplasmy levels in blood. This assay provides definitive genotypic evidence; however, results must be contextualised with neurological examination, plasma lactate/pyruvate ratios, and cerebral imaging. Genetic counselling is indispensable for recurrence risk estimation and family‑based cascade testing.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠️ Medication Advisory
Do not discontinue prescribed therapy without consulting your physician.
Abrupt cessation of anticonvulsants, metabolic cofactors (riboflavin, coenzyme Q10, thiamine), or supportive medications can precipitate acute metabolic decompensation, seizures, or encephalopathy. Any dose adjustment must be supervised by the treating neurologist or metabolic specialist.
🚨 Patient Exclusion & Emergency Criteria
- Exclusion Criteria: Acute systemic infection with haemodynamic instability requiring inpatient care; known hypersensitivity to phlebotomy materials; patients currently receiving blood transfusion (may interfere with mitochondrial DNA extraction).
- Emergency Red Flags – Seek Immediate Care (Call 998): Sudden onset of muscle weakness with respiratory difficulty, altered consciousness, status epilepticus, or acute vision loss.
Patient FAQ & Clinical Guidance
1. What is the MT‑TN gene and why is it tested?
MT‑TN provides the genetic code for a mitochondrial transfer RNA essential for complex I assembly. Testing identifies pathogenic variants responsible for Leigh syndrome, encephalomyopathy, and other mitochondrial disorders. Early molecular diagnosis guides metabolic management and family genetic counselling.
2. Do I need any special preparation before the blood draw?
No fasting or medication adjustments are required. Please bring any prior neurological imaging reports, metabolic laboratory results, and a three‑generation pedigree chart if available. Our phlebotomist will collect a standard peripheral blood sample at your preferred location.
3. Is this genetic test suitable for children?
Yes, with explicit written parental or guardian consent and a referral from a paediatric neurologist or metabolic specialist. All paediatric testing adheres to the UAE’s medical liability framework and data protection regulations. A dedicated paediatric counselling session is provided before sample collection.
4. How are results delivered and interpreted?
A detailed clinical report is issued within 21–28 days, including variant classification per ACMG standards, heteroplasmy levels, and clinical interpretive comments. A complimentary telephonic session with our Consultant Medical Genetics is scheduled to explain findings, discuss recurrence risks, and coordinate cascade screening for at‑risk relatives.
UAE Regulatory & Data Privacy Adherence
🏛️ Regulatory Compliance & Data Protection
- Personal Data Protection: All genetic and clinical data are processed in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health ICT Regulation: Laboratory information systems and telehealth counselling infrastructure comply with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Medical Liability & Consent: Sample collection, genetic testing, and result disclosure are governed by Federal Decree‑Law No. 4 of 2016 on Medical Liability; explicit informed consent is obtained prior to any procedure.
- Quality Certification: ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) ensuring rigorous quality management across pre‑analytical, analytical, and post‑analytical phases.
Clinical & Logistical Metadata
| Test Name | MT-TN Gene Sequencing for Mitochondrial Complex I Deficiency (Genetic Test) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks (21–28 calendar days) |
| Sample Type / Matrix | Peripheral Whole Blood (3–5 mL in EDTA tube); VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily 8 AM–11 PM |
| Methodology Used | Next‑Generation Sequencing (Illumina NovaSeq 6000) with dual‑index library preparation, ≥1000× depth, and GATK bioinformatic pipeline for heteroplasmy detection |
| ICD-10-CM Code | E88.49 |
| LOINC Code | 81286-7 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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