Test Price
2,800 AED✅ Home Collection Available
MT-TL1 Gene MELAS Syndrome Genetic Test in UAE – 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) accredited NGS processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic post-test clinical guidance for result interpretation by a genetic counselor.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced mitochondrial DNA test screens the entire MT-TL1 gene by Next-Generation Sequencing (NGS) to confirm or rule out MELAS syndrome—a multi‑system disorder with stroke‑like episodes, cardiomyopathy, and lactic acidosis. Full gene coverage includes deep intronic and exon‑boundary regions, ensuring detection of rare variants missed by Sanger sequencing.
| Feature | Our Test (MT-TL1 NGS) | Closest Alternative (Single‑Gene Sanger Sequencing) |
|---|---|---|
| Precision | Full gene coverage including deep intronic/exon boundaries | Targeted known point mutations only; may miss rare variants |
| Method | Next‑Generation Sequencing (NGS) with 99.9% analytical sensitivity | Capillary electrophoresis; lower detection of low‑level heteroplasmy |
| Turnaround Time | 3–4 weeks | 4–6 weeks |
Physician Insight & Safety Protocols
“MT‑TL1 variant detection requires delicate clinical correlation with neurological and cardiological findings; not every mutation manifests as full‑blown MELAS. Genetic counselling before testing is essential to interpret results in the context of the family pedigree.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠️ Medication Advisory
Do not discontinue prescribed medication without consulting your doctor. Some medications may influence mitochondrial function; always inform your physician of any ongoing treatments.
⛔ Exclusion Criteria & Emergency Red Flags
- Individuals unable to provide informed consent (minors require legal guardian consent per Federal Decree‑Law No. 4 of 2016 on Medical Liability).
- Acute medical crisis requiring immediate hospitalization – postpone elective genetic testing.
- If you experience sudden severe headache, visual disturbance, one‑sided weakness, or signs of lactic acidosis (deep rapid breathing, confusion), seek emergency care immediately.
Patient FAQ & Clinical Guidance
1. How does an MT‑TL1 mutation cause MELAS syndrome?
Mutations in the MT‑TL1 gene disrupt mitochondrial transfer RNA leucine 1, crippling the production of proteins essential for the cell’s energy factories, which triggers stroke‑like episodes and lactic acidosis. This defect leads to heteroplasmic accumulation of dysfunctional mitochondria, explaining the variable severity and multi‑organ involvement.
2. Do I need a genetic counselling session before this test?
Yes, pre‑test genetic counselling is mandatory to draw a detailed pedigree chart of affected family members and to discuss the inheritance pattern of mitochondrial DNA disorders. A board‑certified genetic counsellor will explain the implications of a positive, negative, or variant of uncertain significance result, ensuring you make an informed decision.
3. Why does this test take 3 to 4 weeks to report?
The 3–4 week turnaround includes DNA extraction, NGS library preparation, massively parallel sequencing, bioinformatics analysis, and a multi‑step clinical variant interpretation by board‑certified molecular geneticists to ensure diagnostic accuracy. Each step is performed under ISO 9001:2015 quality controls, and heteroplasmy quantification requires deep coverage, adding to the careful timeline.
UAE Regulatory & Data Privacy Adherence
This diagnostic service strictly complies with the UAE Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data processed is governed by data minimization and purpose limitation principles. The DHA‑licensed facility (License No. 1143) ensures secure handling and storage of your biological samples and clinical information.
Clinical & Logistical Metadata
| Test Name | MT‑TL1 Gene (MELAS Syndrome) NGS Analysis |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or buccal swab; DNA extraction required |
| Methodology Used | Next‑Generation Sequencing (NGS) targeting the mitochondrial MT‑TL1 gene |
| ICD‑10‑CM Code | E88.41 |
| LOINC Code | 81209-0 |
| DHA Facility License & Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians