Test Price
2,800 AED✅ Home Collection Available
MT-TF Gene MELAS Syndrome Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Test Overview & Methodology
The MT-TF gene NGS test decodes the mitochondrial tRNA‑Phe gene to diagnose MELAS syndrome—a maternally inherited multi‑system disorder. It delivers a comprehensive variant analysis with clinical‑grade precision, empowering early intervention and family planning.
| Feature | DNA Labs UAE NGS Test | Single‑Variant PCR Alternative |
|---|---|---|
| Precision | Full‑gene coverage, detects known & novel variants | Targets only one known variant |
| Methodology | Next‑Generation Sequencing (NGS) + Sanger confirmation | Allele‑specific PCR |
| Turnaround Time | 3–4 Weeks | 2–3 Weeks (limited information) |
Physician Insight & Safety Protocols
"Mitochondrial disorders like MELAS require meticulous genotype-phenotype correlation. The MT-TF NGS test provides comprehensive coverage, but results must be contextualized within the patient's clinical presentation, biochemical profile, and family history. Post-test genetic counseling is essential for managing recurrence risks and initiating appropriate surveillance."
— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Medication & Clinical Safety Advisory
⚠️ Do not discontinue any prescribed medication without consulting your doctor. Abrupt changes may precipitate a metabolic crisis in MELAS patients. This test is for diagnostic confirmation and should not replace emergency care.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Recent blood transfusion (≤4 weeks), active febrile illness, or hematopoietic stem cell transplant (risk of chimerism).
- Exclusion: Inability to provide informed genetic consent or lack of guardian for minors (per UAE Medical Liability Law).
- Emergency Red Flag: New‑onset stroke‑like symptoms, intractable seizures, or acute cardiac decompensation after sample collection — proceed to the nearest emergency department immediately.
Patient FAQ & Clinical Guidance
1. What is the MT-TF gene and its role in MELAS syndrome?
The MT-TF gene encodes mitochondrial transfer RNA for phenylalanine; pathogenic variants disrupt mitochondrial protein synthesis, causing the multi‑system energy failure typical of MELAS syndrome.
2. How accurate is NGS for detecting MT-TF mutations?
NGS achieves >99.9% analytical sensitivity for all pathogenic MT-TF variants, with specificity enhanced by Sanger confirmation and expert genotype‑phenotype correlation.
3. Who should consider this genetic test?
Individuals with unexplained stroke‑like episodes, cardiomyopathy, or lactic acidosis, especially those with a maternal family history, are prime candidates for MT-TF gene testing.
4. What sample type is required and how is it collected?
A standard peripheral whole blood sample is required. DNA Labs UAE offers VIP Mobile Phlebotomy services (8 AM to 11 PM) for home collection, ensuring temperature-controlled cold-chain transport to our ISO-accredited laboratory.
5. How long does it take to receive results?
The turnaround time for the MT-TF Gene MELAS Syndrome Genetic Test is 3 to 4 weeks due to the comprehensive nature of NGS sequencing and confirmatory Sanger analysis.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance: All genetic testing at DNA Labs UAE is performed in strict adherence to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genomic data is encrypted, access-controlled, and never shared without your explicit, informed consent.
Clinical & Logistical Metadata
| Test Name | MT-TF Gene MELAS Syndrome Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available (8 AM–11 PM) |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | E88.41 |
| LOINC Code | 80872-1 |
| DHA Facility License & Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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