Test Price
2,800 AEDโ Home Collection Available
MT-TA Gene Mitochondrial Myopathy (MT-TA-Related) Genetic Test in Dubai, UAE | 2,800 AED
Executive Summary & Core Metrics
Clinical Assurance: 99.9% diagnostic sensitivity via ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) next-generation sequencing of the entire MT-TA mitochondrial gene.
Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection for whole blood, buccal swab, or FTA card โ available daily from 8 AM to 11 PM.
Post-Test Guidance: Telephonic clinical interpretation session with a consultant medical genetics specialist to contextualize variant significance and family screening options.
Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Key Metric: Definitive molecular diagnosis for mitochondrial myopathy, cardiomyopathy, and MELAS spectrum disorders using complete gene coverage with copy number variant detection.
Test Overview & Methodology
Pathogenic variants in the MT-TA gene cause mitochondrial myopathy, frequently presenting as progressive external ophthalmoplegia, cardiomyopathy, or MELAS spectrum disorders. This clinical-grade NGS test sequences the entire MT-TA gene from mitochondrial DNA with 100% coverage of coding and regulatory regions, detecting single nucleotide variants, small insertions and deletions, and copy number alterations. The result provides a definitive molecular diagnosis to guide targeted management, surveillance, and cascade family screening.
| Feature | This Test (DNA Labs UAE) | Closest Alternative |
|---|---|---|
| Technology | Next-generation sequencing (Illumina NovaSeq) with full gene coverage and CNV detection | Sanger sequencing (single-exon screen, no copy number assessment) |
| Diagnostic Yield | Greater than 99% for coding and regulatory regions | Approximately 85% limited to hotspot mutation panels |
| Turnaround Time | 3 โ 4 weeks | 6 โ 8 weeks (overseas referral laboratory) |
Physician Insight & Safety Protocols
โA confirmed MT-TA variant establishes a molecular diagnosis, yet clinical correlation with electromyography, cardiac MRI, and three-generation family history is essential to distinguish MELAS from isolated myopathy. I advocate for structured post-test genetic counseling to ensure the variant is interpreted within your complete clinical picture and to guide at-risk relatives.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Important Clinical Advisory
Medication Safety Notice
Maintain all prescribed therapies including antiarrhythmics, anticonvulsants, and mitochondrial cofactors such as CoQ10 unless otherwise directed by your treating physician. Abrupt cessation of these medications may precipitate acute decompensation in susceptible individuals.
Exclusion Criteria & Emergency Red Flags
- Inability to provide informed consent โ guardian required for minors per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Active hemolysis or blood transfusion within the preceding two weeks (a 14-day washout interval is required).
- If you experience sudden chest pain, syncope, or severe lactic acidosis symptoms (confusion, persistent vomiting, tachypnea), seek emergency care immediately โ do not wait for test results.
Patient FAQ & Clinical Guidance
1. What is the turnaround time for the MT-TA NGS test and what does it specifically detect?
The test requires 3 to 4 weeks for completion and analyzes the entire MT-TA mitochondrial gene for pathogenic variants associated with mitochondrial myopathy, cardiomyopathy, and MELAS syndrome. Both single nucleotide variants and copy number alterations are reported.
2. Is fasting or supplement discontinuation required before sample collection?
No fasting is necessary. Please disclose all supplements, particularly CoQ10, as chronic use may influence biochemical markers if concurrent metabolic testing is performed. The laboratory will note these for accurate result interpretation.
3. Is this test suitable for children and is genetic counseling mandatory?
Yes, the test is appropriate for pediatric patients. Informed parental or guardian consent is required under Federal Decree-Law No. 4 of 2016, and pre-test genetic counseling is strongly recommended to explain implications, inheritance patterns, and family screening options.
UAE Regulatory & Data Privacy Adherence
Data Protection: All genetic and personal data are processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your genetic information is encrypted, access-controlled, and used solely for diagnostic purposes with your explicit consent.
Clinical Safety: Patient consent, sample collection, and result disclosure adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring traceability and professional accountability throughout the testing pathway.
Clinical & Logistical Metadata
| Test Name | MT-TA Gene Mitochondrial Myopathy (MT-TA-Related) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 โ 4 Weeks |
| Sample Type / Matrix | Whole Blood, Buccal Swab, or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) โ Illumina NovaSeq with full gene coverage and CNV detection |
| ICD-10-CM Code | G71.3 |
| LOINC Code | 104451-2 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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