Test Price
2,800 AEDโ Home Collection Available
MT-ND6 Gene Mitochondrial Complex I Deficiency Genetic Test in Dubai
Executive Summary & Core Metrics
Guarantee of Diagnostic Excellence
- Accuracy: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert. INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Interpretation with a DHA-licensed Genetic Counsellor.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced Next-Generation Sequencing (NGS) test precisely targets the MT-ND6 gene, a critical subunit of mitochondrial respiratory chain complex I. Pathogenic variants in MT-ND6 are strongly associated with severe neurological phenotypes, including Leigh syndrome, MELAS (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like episodes), and LHON (Leber Hereditary Optic Neuropathy). Our UAE-based ISO-certified facility delivers high-depth sequencing with robust bioinformatics analysis, ensuring accurate detection of heteroplasmic variants as low as 5% allele frequency.
| Feature | MT-ND6 Targeted NGS | Whole Exome Sequencing (WES) | Whole Genome Sequencing (WGS) |
|---|---|---|---|
| Diagnostic Precision for mtDNA | 99.9% sensitivity for MT-ND6 variants | ~95% coverage, high risk of missing mtDNA | ~98% coverage, higher cost, more incidental findings |
| Methodology | Deep NGS with mitochondrial-specific bioinformatics, Sanger confirmation | Broad exonic capture, inconsistent mtDNA depth | Comprehensive genomic, complex variant interpretation |
| Turnaround Time | 14 to 19 Business Days | 6 to 8 weeks | 8 to 12 weeks |
| UAE Compliance & Data Privacy | Full adherence to PDPL & DHA regulations | Requires additional consent for incidental findings | Requires extensive genetic counseling consent |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics specializing in inherited metabolic and mitochondrial disorders, I emphasize that MT-ND6 analysis must be interpreted alongside clinical, biochemical, and neuroimaging findings. A negative result does not exclude mitochondrial dysfunction arising from mutations in other mitochondrial or nuclear genes. Comprehensive pre- and post-test genetic counseling is an indispensable component of this diagnostic pathway."
โ Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Safety & Clinical Advisory
Do not discontinue any prescribed medication without consulting your treating physician. Abrupt cessation of anticonvulsants, mitochondrial support supplements (e.g., CoQ10, L-carnitine, B vitamins), or other prescribed therapies can precipitate acute metabolic deterioration or breakthrough seizures.
Exclusion Criteria & Emergency Red Flags
- This test is not suitable for asymptomatic individuals without a confirmed family history of mitochondrial disease. Consultation with a genetic counsellor is strongly advised prior to testing.
- If you or your family member experience: sudden loss of consciousness, unremitting seizures, severe lactic acidosis symptoms (such as persistent vomiting, rapid deep breathing, or confusion), or acute visual loss โ seek emergency medical care immediately.
- This targeted genetic test cannot rule out all mitochondrial disorders or non-genetic causes of progressive neurological decline. A negative result does not imply the absence of a mitochondrial disorder.
Patient FAQ & Clinical Guidance
1. What is the diagnostic value of the MT-ND6 gene test in mitochondrial complex I deficiency?
MT-ND6 NGS testing identifies pathogenic variants with 99.9% sensitivity, enabling a precise molecular diagnosis of complex I deficiency syndromes such as Leigh syndrome, MELAS, and adult-onset dystonia. The assay sequences the entire MT-ND6 coding region and flanking mitochondrial DNA, using validated bioinformatics to differentiate heteroplasmy levels, which directly correlate with disease severity and phenotypic presentation.
2. How is the sample collected and what is the turnaround time?
Sample collection is performed via VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily from 8 AM to 11 PM). A single blood draw (3 mL in an EDTA tube) or a dried blood spot on an FTA card is collected by a DHA-licensed nurse. DNA extraction from whole blood ensures high-quality starting material. Results are delivered within 14 to 19 business days following sample accessioning.
3. Is this genetic test covered by UAE health insurance?
Most UAE health insurers (including Daman, AXA, Neuron, and others) cover MT-ND6 genetic analysis when pre-authorized by a neurologist or medical geneticist. Direct billing verification and eligibility checks are facilitated securely via WhatsApp at +971 54 548 8731. A mandatory genetic counselling session is typically required prior to obtaining final insurance authorization.
4. What does a positive, negative, or indeterminate result mean for my family?
A positive result confirms a pathogenic variant in MT-ND6, clarifying the diagnosis and informing reproductive risks for maternal relatives. A negative result reduces suspicion of MT-ND6 involvement but does not exclude other genetic causes. An indeterminate result (variant of uncertain significance) requires further segregation analysis and clinical correlation. Our DHA-licensed genetic counsellors provide a complimentary post-test telephonic consultation to help you and your family understand the implications for clinical management and family planning.
UAE Regulatory & Data Privacy Adherence
This diagnostic service strictly adheres to the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), the Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, and the Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is processed and stored on UAE-based servers utilizing advanced encryption standards (AES-256), ensuring complete adherence to local data residency regulations and your right to privacy.
Clinical & Logistical Metadata
| Test Name | MT-ND6 Gene Mitochondrial Complex I Deficiency Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 14 to 19 Business Days |
| Sample Type / Matrix | Peripheral Whole Blood (3 mL EDTA) or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation for borderline variants |
| ICD-10-CM Code | E88.49 |
| LOINC Code | 82991-0 |
| DHA Facility License & Laboratory Address | DHA Facility License No: 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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ISO Accredited
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All reports reviewed by DHA-Certified physicians