Test Price
2,800 AED✅ Home Collection Available
MT-ND5 Gene Mitochondrial Complex I Deficiency Genetic Test in UAE | 2800 AED | NGS Analysis
Executive Summary & Core Metrics
Executive Summary
- Diagnostic Accuracy: >99.9% analytical sensitivity for point mutations and small indels via ISO 9001:2015 certified laboratory processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM for standard whole blood specimens.
- Clinical Guidance: Post-test telephonic consultation for result interpretation by a Consultant Medical Genetics specialist.
- Insurance Verification: Direct coverage check via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The MT-ND5 Gene Mitochondrial Complex I Deficiency Genetic Test employs advanced next-generation sequencing to analyze the MT-ND5 gene for pathogenic variants associated with mitochondrial respiratory chain disorders, specifically Complex I deficiency. This diagnostic screen supports neurologists, medical geneticists, and metabolic specialists in diagnosing and managing conditions such as Leigh syndrome, MELAS, and other mitochondrial encephalomyopathies. Turnaround time is 21–28 calendar days at 2800 AED.
| Feature | Our Test (NGS MT-ND5) | Standard Single-Gene Sanger Sequencing |
|---|---|---|
| Precision | >99.9% analytical sensitivity for point mutations and small indels | ~99.0% sensitivity; lower detection of heteroplasmy |
| Methodology | NGS with deep coverage of MT-ND5 gene; detects heteroplasmy down to 1% | Capillary electrophoresis; limited heteroplasmy quantification |
| Turnaround Time | 21–28 calendar days | 6–8 weeks |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics registered with the Dubai Health Authority (DHA ID: 9294403), I recognize the profound uncertainty that families face when pursuing a mitochondrial genetic diagnosis. The MT-ND5 NGS test provides a precise molecular window into Complex I-related disorders, yet results must always be contextualized within the full clinical presentation and family pedigree. A negative result does not exclude all mitochondrial pathologies, and any pathogenic finding warrants comprehensive genetic counselling before clinical action." — Lina Osama Zaki Quteineh, Consultant Medical Genetics
Medication Advisory
Medication Advisory
Do not discontinue any prescribed therapy—particularly anti-epileptics, coenzyme Q10, or mitochondrial supplements—without explicit guidance from your treating physician. Abrupt cessation may exacerbate neurological symptoms or trigger metabolic decompensation.
Safety Exclusion Criteria & Emergency Red Flags
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Patients unable to provide informed consent, minors without legal guardian consent per Federal Decree-Law No. 4 of 2016 on Medical Liability, or individuals with severe coagulopathy precluding blood draw.
- Red Flags: New-onset status epilepticus, acute metabolic decompensation manifesting as vomiting, lethargy, or hypoglycemia, and stroke-like episodes require immediate emergency intervention. Do not delay presentation for genetic testing; proceed to the nearest UAE emergency department.
Patient FAQ & Clinical Guidance
1. What is the MT-ND5 gene test, and when is it recommended?
The MT-ND5 test screens for mitochondrial DNA mutations causing Complex I deficiency. It is essential for diagnosing early-onset neurological or multisystem disorders such as Leigh syndrome and MELAS. This test is typically ordered by neurologists, geneticists, or metabolic specialists when mitochondrial disease is clinically suspected.
2. How should I prepare for the MT-ND5 blood draw or DNA sample collection?
No fasting is required. A standard whole blood sample collected via venipuncture is sufficient. Alternatively, extracted DNA or a dry FTA card with a single drop of blood can be submitted. Our VIP mobile phlebotomy service can collect samples at your home between 8 AM and 11 PM daily.
3. What is the clinical accuracy of the NGS method for this test?
The test achieves >99.9% diagnostic sensitivity with ISO 9001:2015 certified processing, ensuring reliable detection of low-heteroplasmy variants linked to MT-ND5 disease. This deep-coverage NGS approach identifies mutations down to 1% heteroplasmy, which standard Sanger sequencing may miss.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License Number 1143 and fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-restricted, and processed solely for diagnostic purposes. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | MT-ND5 Gene Mitochondrial Complex I Deficiency Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21–28 calendar days |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) with deep coverage of MT-ND5 gene; heteroplasmy detection down to 1% |
| ICD-10-CM Code | E88.49 |
| LOINC Code | 101374-8 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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