Test Price
2,800 AED✅ Home Collection Available
MT-ND3 Gene Sequencing for Leigh Syndrome (Mitochondrial Complex I Deficiency) – DHA Licensed Laboratory in Dubai | DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily 8 AM – 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed specialists.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The MT-ND3 gene sequencing test detects pathogenic variants causing Leigh syndrome, a severe neurometabolic disorder due to mitochondrial complex I deficiency. This test analyzes the gene responsible for cellular energy production to confirm diagnosis and guide treatment. Using next-generation sequencing (NGS), it provides comprehensive coverage of the MT-ND3 gene with high analytical sensitivity.
| Feature | Our Test (DHA-Certified) | Closest Alternative |
|---|---|---|
| Precision | NGS with >99.9% analytical sensitivity | Single‑gene Sanger, lower mutation coverage |
| Method | Next‑Generation Sequencing (full gene) | Targeted PCR and capillary electrophoresis |
| Turnaround | 3–4 Weeks | 4–6 Weeks (often with reflex tests) |
Physician Insight & Safety Protocols
“A positive MT-ND3 result must be correlated with clinical presentation and family history. This test provides a molecular diagnosis but does not predict individual severity; post‑test genetic counselling is essential for informed decision‑making.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Clinical Advisory
Do not discontinue any prescribed medication or supplement without consulting your treating physician. Test results alone do not replace clinical judgment.
Safety Exclusion Criteria & Red Flags
- Exclusion: Inability to provide a blood sample or extracted DNA on FTA card; known hematologic instability.
- Red Flag (ER): If the patient develops acute metabolic crisis (vomiting, seizures, respiratory distress), immediately seek emergency care before scheduling the test.
- Minors: Testing for minors requires consent from legal guardians in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What does the MT-ND3 gene test for Leigh syndrome reveal?
This genetic test identifies pathogenic variants in the MT-ND3 gene linked to Leigh syndrome, providing clinicians with a definitive molecular diagnosis and guiding prognosis and family planning.
2. Why is pre‑test genetic counselling mandatory for this test?
Genetic counselling ensures you understand the implications of a positive, negative, or uncertain result and helps construct a complete family pedigree, aligning with DHA ethical standards for genetic testing.
3. How accurate is the MT-ND3 NGS test and what is the turnaround time?
Using ISO 9001:2015 accredited next-generation sequencing, the test delivers >99.9% analytical sensitivity for MT-ND3 variants. Results are typically ready within 3 to 4 weeks, offering one of the fastest genomic insights in the UAE.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance
Your data is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory holds DHA Facility License No. 1143 and operates under the stringent quality framework of DNA Labs UAE.
Clinical & Logistical Metadata
| Test Name | MT-ND3 Gene Sequencing (Leigh Syndrome, Mitochondrial Complex I Deficiency) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) or Extracted DNA (FTA Card) |
| Methodology Used | Next-Generation Sequencing (Full Gene) |
| ICD-10-CM Code | G31.81 (Leigh Syndrome) |
| LOINC Code | 53452-5 (Mitochondrial DNA Sequencing) |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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