Test Price
2,800 AEDโ Home Collection Available
MT-CO3 Gene Analysis for Mitochondrial Complex IV Deficiency (NGS) in UAE โ 2800 AED โ DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 15189-accredited Next Generation Sequencing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary post-test telephonic genetic counselling and result interpretation with a DHA-licensed specialist.
- Insurance: Direct Billing Verification โ send your policy via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This genetic test analyses the entire coding region of the mitochondrial MT-CO3 gene to detect pathogenic variants causing cytochrome c oxidase (Complex IV) deficiency. It provides definitive molecular diagnosis for Leigh syndrome, mitochondrial encephalomyopathy, and other progressive neurological disorders. The assay employs Next Generation Sequencing (NGS) with a validated bioinformatics pipeline, achieving a minimum coverage depth of 500x for robust single nucleotide variant, small indel, and copy number variation detection.
Pre-Test Requirements & Sample Types
- Genetic Counselling: A mandatory pre-test session with a certified genetic counsellor to draw a detailed pedigree chart of family members affected by mitochondrial disorders.
- Clinical History: Full neurological and metabolic history must be provided to aid variant interpretation.
- Accepted Specimens: Whole blood (EDTA), extracted DNA, or FTA card sample. All specimens are transported under cold-chain protocols per UAE Ministry of Health and Prevention (MOHAP) regulations.
| Feature | DNA Labs UAE Onshore Test | Overseas Send-Out Alternative |
|---|---|---|
| Precision (Variant Detection) | 99.9% Sensitivity (โฅ500x coverage, SNV, indel & CNV analysis) | 99.5% (Standard coverage, possible incomplete gene coverage) |
| Methodology | Next Generation Sequencing (NGS) with validated bioinformatics pipeline | Sanger sequencing (often limited to hotspot regions) |
| Turnaround Time | 3โ4 Weeks (DHA-licensed facility onshore) | 6โ8 Weeks (customs and shipping delays) |
| Clinical Support | DHA-licensed Consultant Medical Geneticist and genetic counsellor integrated | Report only; no local regulatory oversight |
| Price | 2,800 AED (all-inclusive with VIP home collection) | 3,000โ4,500 AED (plus shipping and handling) |
Physician Insight & Safety Protocols
"This test is a powerful diagnostic tool, but it must always be interpreted within the context of a thorough clinical evaluation. A negative result does not exclude mitochondrial disease, and a positive result should be correlated with biochemical and imaging findings. Every patient receives guidance through a multidisciplinary team approach."
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Important Clinical Advisory
Medication Management Notice
Do not discontinue, adjust, or initiate any prescribed medication including anticonvulsants, coenzyme Q10, or dietary supplements without consulting your treating physician. Test results are for diagnostic clarification only and do not constitute treatment recommendations.
Exclusion Criteria & Emergency Red Flags
- Individuals who have undergone allogeneic stem cell transplantation within the last 12 weeks may show donor DNA interference.
- Active severe infection or systemic inflammation that could degrade sample quality โ reschedule collection.
- Emergency Warning: If you or your child experiences acute neurological deterioration, seizures, metabolic crisis, or loss of consciousness, immediately go to the nearest Emergency Department; do not wait for test results.
- This test is not intended for prenatal diagnosis unless specifically ordered and counselled by a fetal medicine specialist.
Patient FAQ & Clinical Guidance
1. What does the MT-CO3 gene test detect and how reliable is it?
Our NGS-based MT-CO3 analysis identifies single nucleotide variants, small insertions/deletions, and copy number changes with 99.9% sensitivity, making it the most accurate molecular diagnostic method for mitochondrial Complex IV deficiency available in the UAE today.
2. Is fasting required before blood sample collection?
No fasting is required. However, please inform the phlebotomy team of all current medications and supplements for accurate clinical documentation.
3. How will my genetic data be protected under UAE law?
Your genomic information is strictly safeguarded per Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Data is only shared with your referring physician and never with third parties without your explicit written consent.
4. How long does it take to get results and how will I receive them?
Turnaround time is 3 to 4 weeks from sample receipt. Results are delivered electronically to your referring physician and to you via a secure patient portal, followed by a telephonic genetic counselling session to explain the findings.
UAE Regulatory & Data Privacy Adherence
Data Protection: All genetic and clinical data are processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
Accreditations: ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) and ISO 15189-accredited laboratory processes. DHA Facility License No. 1143.
Clinical & Logistical Metadata
| Test Name | MT-CO3 Gene Analysis for Mitochondrial Complex IV Deficiency (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card Specimen |
| Methodology Used | Next Generation Sequencing (NGS) with โฅ500x Coverage |
| ICD-10-CM Code | E88.40, G31.82, Z13.79 |
| LOINC Code | 82939-8 |
| DHA Facility License & Address | License No. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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