Test Price
2,800 AED✅ Home Collection Available
MT-CO1 Gene Cytochrome c Oxidase Subunit I Deficiency Genetic Test
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited NGS Processing
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection, available daily 8 AM–11 PM
- Clinical Guidance: Telephonic Post‑Test Genetic Counseling and result interpretation
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731
This advanced genetic test delivers precise molecular diagnosis of cytochrome c oxidase deficiency associated with MT‑CO1 pathogenic variants, using whole‑gene NGS.
Test Overview & Methodology
This state‑of‑the‑art genetic test utilises Next‑Generation Sequencing (NGS) to fully analyse the MT‑CO1 gene for pathogenic variants causing cytochrome c oxidase deficiency, a mitochondrial disorder affecting cellular energy production. The test detects single‑nucleotide variants, small insertions/deletions, and copy‑number changes with high analytical sensitivity, enabling precise diagnosis and differentiation of mitochondrial encephalomyopathies such as Leigh syndrome.
| Feature | Our NGS Test | Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | ≥99.9% analytical sensitivity for SNVs and small indels | ~95% sensitivity; limited to targeted regions |
| Method | Whole‑gene NGS with deep coverage (Illumina® platform) | PCR‑based capillary sequencing of selected exons |
| Turnaround | 3–4 weeks from sample receipt | 6–8 weeks for full gene coverage |
| Coverage | Complete coding region + splice sites | Often partial; may miss deep intronic variants |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist, I recognise the profound impact of a definitive genetic diagnosis for mitochondrial disease. This MT‑CO1 NGS test offers exceptional analytical sensitivity, but the results must always be interpreted in the context of the full clinical picture—including biochemical assays, neuroimaging, and family history. It is a critical tool for guiding personalised management, not a standalone diagnosis.” — Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory
Do not discontinue any prescribed medication or supplement without consulting your treating physician. Genetic test results may inform therapy adjustments; never self‑adjust based on preliminary findings.
Safety Exclusion Criteria & Red Flags
- Exclusion: Individuals unable to provide informed consent, or minors without legal guardian consent, in compliance with Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Exclusion: Acute febrile illness or haemodynamic instability that contraindicates blood draw; defer testing until stabilised.
- Emergency Red Flags: If you experience sudden neurological decline, stroke‑like episodes, severe muscle paralysis, or respiratory distress, seek immediate emergency medical care—do not wait for test results.
Patient FAQ & Clinical Guidance
1. What clinical information does the MT‑CO1 gene test provide?
This test identifies pathogenic variants in the MT‑CO1 gene responsible for cytochrome c oxidase deficiency, enabling precise diagnosis of mitochondrial disorders. It detects single‑nucleotide variants, small insertions/deletions, and copy‑number changes with high sensitivity, helping neurologists differentiate Leigh syndrome from other mitochondrial encephalomyopathies. Results must be correlated with biochemical and imaging findings for a complete clinical picture.
2. How is the home collection process handled in the UAE?
A certified phlebotomist visits your location in a fully equipped mobile unit, ensuring cold‑chain integrity from collection to laboratory. Scheduling is available daily from 8 AM to 11 PM via WhatsApp at +971545488731. The service includes pre‑test genetic counseling and strict adherence to UAE data privacy laws.
3. Will my health insurance cover the cost of this genetic test?
Many UAE insurers cover medically necessary genetic testing for mitochondrial disorders when pre‑authorised by a neurologist. Our team conducts a direct billing verification via WhatsApp at +971545488731 before your appointment, clarifying any co‑payment. We coordinate with providers to streamline approval, and our DHA‑licensed facility is recognised by major networks.
UAE Regulatory & Data Privacy Adherence
Data Protection: This service complies with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent is obtained in accordance with Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Licensing: DNA Labs UAE is fully licensed by the Dubai Health Authority (DHA Facility License No. 1143) and operates under ISO 9001:2015 certification.
Clinical & Logistical Metadata
| Test Name | MT‑CO1 Gene Cytochrome c Oxidase Subunit I Deficiency Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks from sample receipt |
| Sample Type / Matrix | Whole blood (EDTA) — VIP Mobile Phlebotomy & Cold‑Chain Home Collection available daily 8 AM–11 PM |
| Methodology Used | Next‑Generation Sequencing (NGS) on Illumina® platform, whole‑gene coverage |
| ICD‑10‑CM Code | E88.42 (Cytochrome c oxidase deficiency) |
| LOINC Code | 82438‑3 (Mitochondrial DNA gene sequencing) |
| DHA Facility License & Address | License No. 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians