Test Price
2,800 AED✅ Home Collection Available
ATP5F1A Gene Sequencing for Mitochondrial Complex V Deficiency, Nuclear Type 4 (NGS) in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP mobile phlebotomy & temperature-controlled cold-chain home collection daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test genetic counselling from a DHA-licensed specialist for result interpretation.
- Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This advanced next-generation sequencing (NGS) test analyzes the entire coding region of the ATP5F1A gene to diagnose mitochondrial complex V deficiency, nuclear type 4—a rare neurometabolic disorder causing progressive neurological symptoms. It provides definitive molecular confirmation with the highest diagnostic accuracy available in the UAE.
| Feature | Our Test (NGS) | Closest Alternative |
|---|---|---|
| Precision | 99.9% sensitivity, full gene coverage | Sanger sequencing (targeted regions only) |
| Method | Next-generation sequencing (Illumina platform) | Capillary electrophoresis |
| Turnaround time | 3–4 weeks | 4–6 weeks |
| ISO accreditation | ISO 9001:2015 certified | Often not certified |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
"Mitochondrial disorders require careful genetic correlation with clinical presentation. This NGS test offers a precise molecular answer, but it must be interpreted alongside a thorough neurological and metabolic evaluation. Genetic counselling is essential before and after testing to understand implications for the patient and family."
Clinical Advisory
Medication Warning
Do not discontinue any prescribed medication without consulting your doctor. The test results do not override ongoing treatment decisions.
Exclusion Criteria & Emergency Red Flags
- Active febrile illness or recent blood transfusion (may affect DNA quality).
- Inability to provide a valid clinical history or complete a genetic counselling session.
- Patients experiencing acute neurological deterioration should proceed directly to emergency care.
- Seek immediate medical attention if you develop: unexplained seizures, altered consciousness, sudden vision loss, severe muscle weakness, or respiratory distress.
Patient FAQ & Clinical Guidance
1. What does the ATP5F1A gene test detect?
The ATP5F1A gene test accurately detects mutations causing mitochondrial complex V deficiency, nuclear type 4. It identifies pathogenic variants in the ATP5F1A gene, which impair cellular energy production and lead to severe neurological and muscular symptoms. This information is critical for confirming diagnosis, guiding treatment, and family planning.
2. How should I prepare for the test, and what is the collection process?
Fasting is not required, but a dedicated genetic counselling session is mandatory prior to sample collection. Our DHA-licensed mobile phlebotomist will collect a small blood sample or buccal swab at your home using a validated cold-chain kit. The entire process respects UAE PDPL privacy and typically takes less than 15 minutes.
3. When will I receive results, and how are they interpreted?
Your comprehensive report is delivered within 3 to 4 weeks through a secure online portal and includes clinical interpretation by our medical team. Results are classified according to international ACMG guidelines—pathogenic, likely pathogenic, or variant of uncertain significance. A post-test teleconsultation with a DHA-licensed genetic counsellor is included at no additional cost.
UAE Regulatory & Data Privacy Adherence
Compliance with UAE Law
DNA Labs UAE operates under DHA Facility License No. 1143 and adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is handled with strict confidentiality, encrypted in transit and at rest, and used solely for diagnostic purposes with your informed consent. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | ATP5F1A Gene Sequencing for Mitochondrial Complex V Deficiency, Nuclear Type 4 (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or buccal swab; VIP mobile phlebotomy & temperature-controlled cold-chain home collection available daily 8 AM–11 PM |
| Methodology Used | Next-generation sequencing (NGS) on Illumina platform, full gene coding region analysis |
| ICD-10-CM Code | E88.49 (Other disorders of mitochondrial metabolism) |
| LOINC Code | 94891-5 (Gene sequencing panel) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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