Test Price
2,800 AED✅ Home Collection Available
RAG2 Gene Omenn Syndrome Genetic Test (NGS) in Dubai, UAE
Executive Summary & Core Metrics
Achieve definitive molecular diagnosis for Omenn syndrome with 99.9% assay sensitivity using our ISO 9001:2015 certified Next-Generation Sequencing (NGS) platform. This full-gene analysis of RAG2 detects pathogenic variants critical for hematopoietic stem cell transplant (HSCT) planning and family counseling under DHA regulatory standards.
- Price: 2,800 AED
- Turnaround Time: 3–4 Weeks
- Sample Type: Whole Blood (EDTA) or FTA Card
- Methodology: NGS Full Gene Sequencing & CNV Analysis
- DHA Facility License: 1143
Test Overview & Methodology
This test analyzes the entire coding region and exon-intron boundaries of the RAG2 gene (Recombination Activating Gene 2). Pathogenic variants in RAG2 cause Omenn syndrome, a severe combined immunodeficiency (SCID) characterized by erythroderma, lymphadenopathy, hepatosplenomegaly, and elevated IgE. Early molecular confirmation via NGS is essential for guiding life-saving bone marrow transplant decisions and providing accurate recurrence risk counseling to families.
Methodology: Genomic DNA is extracted and enriched for target regions using hybrid capture probes. Sequencing is performed on an Illumina Novaseq 6000 platform to a mean depth of 100x. Bioinformatic analysis follows ACMG/AMP 2024 guidelines for variant classification, with all reportable variants confirmed by Sanger sequencing for maximum clinical accuracy.
| Feature | DNA Labs UAE (NGS) | Standard Single-Gene Sequencing |
|---|---|---|
| Diagnostic Coverage | Full gene (exons, intron boundaries, deep intronic variants) | Limited to targeted exons & splice sites |
| Turnaround Time | 3–4 Weeks | 8–12 Weeks |
| Variant Detection | SNVs, Indels, CNVs & Sanger confirmation | SNVs only, no copy number analysis |
Physician Insight & Safety Protocols
“While biallelic loss-of-function variants in RAG2 typically present as classical Omenn syndrome, hypomorphic variants can manifest as atypical SCID or combined immunodeficiency with granulomas. Therefore, NGS-based full gene sequencing is essential to capture the full mutational spectrum. Results must be integrated with absolute lymphocyte counts, T-cell receptor excision circles (TREC) from newborn screening, and clinical phenotype. A negative result does not exclude other SCID genotypes, such as RAG1, DCLRE1C, or ADA deficiencies.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Important Clinical Advisory
Medication & Management Precautions
Do not discontinue prescribed immunosuppressants, prophylactic antibiotics, or intravenous immunoglobulin (IVIG) therapy without consulting your immunologist. Genetic diagnosis informs long-term management but does not alter acute infection protocols. Always maintain current vaccination records for household members to protect the immunocompromised patient.
Safety Exclusion Criteria & Red Flags
- Active severe infection requiring hospitalization – postpone elective testing until clinical stability is achieved.
- Recent stem cell transplant (within 6 months) may yield donor DNA artefacts; coordinate with transplant team for accurate chimerism interpretation.
- Minors (<18 years) require valid e-consent from both parents, registered with the DHA, as per Federal Law No. 2 of 2019.
- Emergency Red Flags – proceed to ER: sudden respiratory distress, cyanosis, sepsis-like symptoms, or unexplained bleeding post-collection.
Patient FAQ & Clinical Guidance
1. What does the RAG2 NGS genetic test detect?
This test sequences the entire RAG2 gene to identify pathogenic variants causing Omenn syndrome, a life-threatening immune disorder characterized by erythroderma, hepatosplenomegaly, and markedly elevated IgE. It differentiates Omenn syndrome from other SCID forms, guiding precise treatment and stem cell transplant planning.
2. How is the sample collected, and is preparation required?
A small peripheral whole blood sample (2–5 mL in EDTA) or an FTA card is sufficient. No fasting is required. For infants, a heel-prick blood spot can be used. Our VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection service is available daily from 8 AM to 11 PM for standard blood specimens.
3. Will health insurance cover the cost of this test in the UAE?
Coverage varies by plan. Our team verifies benefits directly via WhatsApp (+971545488731) using your insurance card image, often securing approval within 2 hours under DHA mandatory genetic testing provisions for suspected severe combined immunodeficiency (SCID).
4. What is the turnaround time for obtaining results?
The standard turnaround time for the RAG2 full gene NGS test is 3–4 weeks. This includes DNA extraction, sequencing, bioinformatic analysis, medical review, and Sanger confirmation of reportable variants. Urgent cases can be coordinated directly with our genetics department.
UAE Regulatory & Data Privacy Adherence
Your Data is Protected Under UAE Law
DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-restricted, and processed solely for diagnostic purposes with explicit patient consent. Clinical genetic testing safety protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | RAG2 Gene Full Sequencing (Omenn Syndrome / SCID) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or FTA Card. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina Novaseq 6000, Sanger Confirmation, CNV Analysis |
| ICD-10-CM Code | D81.4 (Severe combined immunodeficiency due to Rag1/Rag2 deficiency) |
| LOINC Code | 92815-2 (RAG2 gene full sequencing) |
| DHA Facility License & Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians