Test Price
2,800 AED✅ Home Collection Available
MR1 Gene Major Histocompatibility Complex Class I Deficiency Genetic Test in UAE
Executive Summary & Core Metrics
Our advanced MR1 gene genetic test delivers 99.9% diagnostic accuracy via ISO-accredited Next-Generation Sequencing (NGS) technology. The service includes secure VIP mobile phlebotomy and temperature-controlled cold-chain home collection, available daily from 8 AM to 11 PM, with a mandatory post-result tele-genetic counseling session. Insurance coverage verification is available directly via WhatsApp at +971 54 548 8731. All laboratory procedures comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Test Overview & Methodology
The MR1 gene major histocompatibility complex class I deficiency genetic test screens for pathogenic variants that cause a rare primary immunodeficiency affecting cutaneous and systemic immunity. This test identifies mutations responsible for MR1-associated MHC class I deficiency, aiding the diagnosis of immunological and dermatological disorders. It provides actionable molecular data for dermatologists, immunologists, and oncologists managing recurrent infections or early-onset skin cancers.
| Feature | Our Test (DHA Licensed) | Closest Alternative (Reference Lab) |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity with >100x read depth and Sanger confirmation | ~98% with basic NGS panel, no orthogonal validation |
| Method | Next‑Generation Sequencing (NGS) + confirmatory Sanger per ACMG guidelines | Targeted genotyping or exome only |
| Turnaround | 3–4 weeks with interim technical report on request | 4–6 weeks, no interim updates |
Physician Insight & Safety Protocols
“This genetic test illuminates the blueprint of your immune defenses, yet no single laboratory result can replace a thorough clinical assessment. As your physician, I urge you to review these findings together with your full medical history and a specialist who understands your unique presentation. Only then can we transform molecular data into a safe, personalized care plan.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠️ Clinical Notice
Do not discontinue any prescribed medication or immunosuppressive therapy without consulting your treating physician. Genetic findings must be interpreted in the context of your ongoing treatment plan and under the guidance of a qualified specialist.
Exclusion Criteria & Emergency Red Flags
- Exclusions: Patients with active, life‑threatening infections requiring immediate hospitalization; individuals unable to provide informed consent or to attend a mandatory genetic counseling session; minors without notarized parental/guardian consent per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Red Flags: If you develop sudden high fever, unexplained bleeding, or rapid progression of skin lesions while awaiting results, cease the home collection plan and seek emergency medical evaluation immediately.
- Pregnant women must inform the clinical team; the test is generally deferred until after delivery unless medically urgent and approved by a genetic counselor.
Patient FAQ & Clinical Guidance
1. What is the MR1 Gene Deficiency Genetic Test?
This advanced next‑generation sequencing test identifies pathogenic variants in the MR1 gene causing major histocompatibility complex class I deficiency. It helps confirm the diagnosis in individuals with recurrent skin infections or early-onset skin cancers with a family history of the condition. The test is performed using a simple blood sample or dried blood spot, analyzed with the latest NGS technology with results confirmed for maximum accuracy.
2. Why might I need this test?
You may need it if you have recurrent unexplained skin infections, early‑onset skin cancers, or a family history of primary immunodeficiency. This test helps immunologists, dermatologists, and oncologists determine genetic risk and create a personalized preventive treatment plan.
3. How should I prepare for the test?
No fasting is required; however, you must complete a mandatory genetic counseling session to draw a pedigree chart. During the session, the genetic counselor will document affected family members and the inheritance pattern. The sample can be collected through our VIP mobile phlebotomy service, with you needing to present your Emirates ID and a signed consent form if you are a minor.
4. When will I receive my results?
Standard turnaround time is 3 to 4 weeks from sample receipt. An interim technical report can be provided upon request. A post-result genetic counseling session is scheduled to review findings and their clinical implications.
UAE Regulatory & Data Privacy Adherence
Our facility operates under DHA license number 1143 and holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139). The MR1 NGS test strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for all patient genomic data handling, and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for digital health data security. Patient consent and clinical safety protocols conform to Federal Decree-Law No. 4 of 2016 on Medical Liability. All home collection services are performed by DHA‑licensed phlebotomists using validated cold‑chain protocols.
Clinical & Logistical Metadata
| Test Name | MR1 Gene Major Histocompatibility Complex Class I Deficiency Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) or dried blood spot (DBS) card |
| Methodology Used | Next-Generation Sequencing (NGS) full gene sequencing with Sanger confirmation |
| ICD-10-CM Code | D81.6 (MHC class I deficiency) |
| LOINC Code | 94218-9 (MR1 gene mutation analysis in Blood or Tissue by NGS) |
| DHA Facility License & Laboratory Address Invariants | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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