Test Price
2,800 AED✅ Home Collection Available
DCLRE1C Gene Omenn Syndrome Genetic Test in UAE | 2800 AED | DHA Licensed Lab
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain and VIP Mobile Phlebotomy — 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation, ensuring every patient understands next steps.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The DCLRE1C gene encodes a protein critical for V(D)J recombination and immune cell development. This NGS test detects pathogenic variants causing Omenn syndrome, a severe combined immunodeficiency presenting in infancy. Early molecular diagnosis enables gene-matched therapy and family planning.
| Feature | Our Test (DNA Labs UAE) | Standard Hospital Panel |
|---|---|---|
| Precision / Method | NGS (Next Generation Sequencing) with full gene coverage, ISO 9001:2015 | Sanger sequencing or targeted mutation panels; limited resolution |
| Turnaround Time | 3 to 4 Weeks | 6–8 Weeks |
| Clinical Sensitivity | 99.9% for single-nucleotide variants, indels, and splice-site mutations | Variable, often lower due to incomplete gene coverage |
| Sample Type | Whole Blood, Extracted DNA, or One-drop Blood on FTA Card | Typically only whole blood |
Physician Insight & Safety Protocols
"The DCLRE1C gene is critical for immune system development. Our comprehensive NGS-based analysis identifies pathogenic variants with high precision, enabling accurate diagnosis of Omenn syndrome. It is essential that these results are interpreted within the full clinical context, ideally by a clinical geneticist or immunologist, to guide therapeutic strategies such as hematopoietic stem cell transplantation."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Medication Advisory
IMPORTANT: Do not alter or discontinue any prescribed treatments, including immunoglobulin therapy or prophylactic antibiotics, based solely on genetic test results. Any therapeutic changes must be overseen by the managing specialist.
Exclusion Criteria & Emergency Red Flags
- Collection may be deferred in cases of acute febrile illness or systemic infection requiring immediate medical attention.
- Recent blood transfusion within 2 weeks may interfere with DNA extraction from whole blood (FTA card alternative is acceptable).
- Seek urgent care if the child develops severe rash, respiratory distress, or failure to thrive while awaiting results — these may indicate Omenn syndrome progression.
- This test is not intended for standalone prenatal diagnosis; consult a genetic counselor for reproductive options.
Patient FAQ & Clinical Guidance
1. What exactly does the DCLRE1C gene test detect and why is it important?
The test identifies mutations in the DCLRE1C gene that cause Omenn syndrome, a life-threatening primary immunodeficiency, enabling precise diagnosis and curative treatment planning. This NGS assay analyzes all coding exons and splice junctions of the DCLRE1C gene using DNA extracted from a simple blood sample. Results guide whether a patient is eligible for hematopoietic stem cell transplantation or gene therapy.
2. How should I prepare my child for the sample collection, and is a fasting state required?
No fasting is required; the main preparation involves arranging a genetic counselling session to draw a family pedigree chart and discuss clinical history. Our phlebotomist will collect either a blood sample, an FTA card spot, or extracted DNA according to the chosen service. The clinical history form should list all affected family members and any previous immunological workup. Home collection is available in all UAE emirates between 8 AM and 11 PM.
3. What is the turnaround time and how will I receive the results?
Results are delivered via a secure encrypted portal within 3 to 4 weeks, accompanied by a comprehensive clinical interpretation and telephonic guidance from our genetic counsellors. You will receive a detailed PDF report including the identified variants, their zygosity, and clinical significance as per ACMG guidelines. Our team then schedules a post-consultation to explain the findings and recommend further immunological evaluations if needed.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License No. 1143, adhering to the highest standards of quality and data security. We fully comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent is obtained in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability. Our ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) reflects our commitment to excellence in genetic diagnostics.
Clinical & Logistical Metadata
| Test Name | DCLRE1C Gene Sequencing & Omenn Syndrome Profile |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or One-drop Blood on FTA Card |
| Methodology Used | Next Generation Sequencing (NGS) – Full Gene Coverage |
| ICD-10-CM Code | D81.8 (Other combined immunodeficiencies) |
| LOINC Code | 92697-6 |
| DHA Facility License & Laboratory Address | DHA License No: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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