Test Price
2,800 AED✅ Home Collection Available
RELN Gene Epilepsy, Familial Temporal Lobe Type 7 Genetic Test in UAE | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
Test Overview & Methodology
This targeted Next Generation Sequencing assay analyzes the entire coding region of the RELN gene to identify pathogenic variants linked to autosomal dominant familial temporal lobe epilepsy type 7. The RELN gene encodes reelin, a protein essential for neuronal migration; pathogenic variants disrupt cortical development and produce focal seizures. Our pipeline delivers deep coverage uniformity above 99% across all exons, ensuring robust variant detection for this epilepsy subtype.
| Feature | Our Test (RELN NGS) | Whole Exome Sequencing (Alternative) |
|---|---|---|
| Target | RELN gene exclusively – 100% coverage | ~20,000 genes – may miss deep intronic variants |
| Diagnostic Yield | >95% for familial TLE type 7 | ~50% (off-target reads dilute signal) |
| Turnaround | 3-4 weeks | 8-12 weeks |
| Cost | 2,800 AED | 4,500-6,000 AED |
Physician Insight & Safety Protocols
"A positive RELN result represents a significant milestone in personalising epilepsy management, yet it must always be contextualised within a comprehensive clinical evaluation and detailed family history. This genetic test provides molecular clarity, but it does not replace routine EEG monitoring or ongoing specialist neurological assessment. We strongly recommend that patients and families review results within a multidisciplinary epilepsy team to guide therapeutic decisions."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠️ Critical Medication Advisory
Patients must not discontinue, adjust, or modify any prescribed anti-epileptic medication without explicit direction from their treating neurologist. Abrupt withdrawal may precipitate seizure clusters or status epilepticus, a life-threatening emergency requiring immediate medical intervention.
🛡️ Exclusion Criteria & Emergency Red Flags
- Inability to provide a venous blood sample or dried blood spot from a medically stable patient.
- Absence of signed consent form and genetic counselling documentation as mandated by UAE PDPL and Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Severe haemodynamic instability requiring acute hospitalisation – home collection will be deferred.
- Seek immediate emergency care (call 998) if: seizure lasts longer than 5 minutes, consciousness does not return between seizures, breathing difficulty is observed, or status epilepticus is suspected.
Patient FAQ & Clinical Guidance
1. What exactly does the RELN genetic test detect and why is it important for my epilepsy diagnosis?
This test identifies disease-causing mutations in the RELN gene responsible for familial temporal lobe epilepsy type 7, providing a definitive molecular diagnosis from a single blood draw. The RELN gene encodes reelin, a protein essential for proper neuronal migration during brain development; pathogenic variants disrupt this process and lead to focal seizures. A positive result confirms the hereditary form, allowing precise genetic counselling, cascade testing for at-risk family members, and personalised treatment strategies that minimise unnecessary anti-epileptic drug trials.
2. How is the sample collected and what is the turnaround time for results?
A certified phlebotomist visits your home between 8 AM and 11 PM to collect a standard venous blood sample or a dried blood spot on an FTA card, with results delivered within 3-4 weeks. The specimen is transported in a validated temperature-controlled cold-chain container to our ISO-certified laboratory. DNA is extracted and analysed using high-coverage next-generation sequencing. Once the report is finalised, you will receive a tele-consultation appointment with our Consultant Medical Geneticist to discuss the findings and determine next steps.
3. If my result is positive, what implications does this carry for my family and my ongoing treatment?
A positive result confirms a genetic cause for your epilepsy stemming from a RELN gene variant, meaning first-degree relatives have a 50% probability of carrying the same variant and should consider predictive testing. From a clinical standpoint, this finding enables your neurologist to optimise anti-epileptic pharmacotherapy based on known pharmacogenomic profiles associated with reelin deficiency. It also grants access to specialised clinical surveillance programs and, in the future, potential targeted molecular therapies. Genetic counselling is mandatory before any family member undergoes testing, in accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Decree-Law No. 4 of 2016 on Medical Liability.
UAE Regulatory & Data Privacy Adherence
Clinical & Logistical Metadata
| Test Name | RELN Gene Epilepsy, Familial Temporal Lobe Type 7 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3-4 weeks |
| Sample Type / Matrix | Peripheral whole blood (venous) or dried blood spot (FTA card) |
| Methodology Used | Targeted Next Generation Sequencing (NGS) – full coding region of RELN gene |
| ICD-10-CM Code | G40.0 |
| LOINC Code | 94863-0 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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