Test Price
2,800 AEDโ Home Collection Available
HCN2 Gene Epilepsy Genetic Test in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
This molecular diagnostic assay screens for pathogenic variants in the HCN2 gene associated with early-onset epileptic encephalopathies and genetic generalized epilepsy. Leveraging Next Generation Sequencing (NGS) with full gene coverage including deep intronic regions, the test delivers a diagnostic sensitivity exceeding 99.9%.
- Price: 2,800 AED
- Turnaround Time: 3โ4 weeks
- Sample Type: Peripheral whole blood
- DHA Licensed Facility: DNA Labs UAE, Dubai Healthcare City
- Pre-Test Requirement: Mandatory genetic counselling session
Test Overview & Methodology
The HCN2 Gene Epilepsy Genetic Test employs Next Generation Sequencing (NGS) to interrogate the full coding region, splice sites, and deep intronic boundaries of the HCN2 gene. This approach detects single nucleotide variants, small insertions and deletions, and copy number variations with high analytical sensitivity. The test is validated for germline genomic DNA extracted from peripheral blood and is intended for individuals with clinical suspicion of genetic epilepsy, particularly early-onset epileptic encephalopathies.
| Feature | Our Test (NGS HCN2) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision / Variant Coverage | Full gene sequencing including deep intronic regions | Exonic and flanking intronic regions only |
| Method | Next Generation Sequencing (NGS) | Sanger sequencing |
| Turnaround Time | 3โ4 Weeks | 2โ3 Weeks |
Physician Insight & Safety Protocols
โGenetic testing results for HCN2 variants require expert clinical correlation within the broader context of seizure semiology, EEG findings, and family history. A positive variant indicates increased susceptibility rather than diagnostic certainty; results should always be discussed with a specialist medical geneticist to guide personalised management and family counselling.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice
โ ๏ธ Important Clinical Guidance
Do not discontinue or alter prescribed antiseizure medication without direct consultation with your treating neurologist. Abrupt medication changes can precipitate seizure exacerbation or status epilepticus.
Exclusion Criteria & Emergency Red Flags
Patient Exclusion Criteria
- Individuals who have not completed a pre-test genetic counselling session with a qualified genetic counsellor.
- Minors without documented parental or legal guardian consent in accordance with UAE Federal Law No. 2 of 2019.
- Patients currently experiencing uncontrolled acute seizure activity (seizure clusters or status epilepticus).
Emergency Red Flags
- Sudden escalation in seizure frequency or severity.
- Prolonged seizure lasting more than 5 minutes (status epilepticus) โ requires immediate emergency medical attention.
Patient FAQ & Clinical Guidance
1. What does the HCN2 Gene Epilepsy NGS test detect?
This test detects pathogenic and likely pathogenic variants in the HCN2 gene, which are associated with early-onset epileptic encephalopathies and genetic generalised epilepsy syndromes. Results are reported according to ACMG/AMP guidelines.
2. How long does it take to receive results?
Results are typically available within 3 to 4 weeks from the date of sample receipt at our laboratory. This timeline includes sequencing, bioinformatics analysis, variant interpretation, and clinical report generation.
3. Is this genetic test covered by insurance in the UAE?
Many UAE insurance plans provide coverage for genetic testing when deemed medically necessary by a specialist. Direct billing verification can be arranged via WhatsApp at +971 54 548 8731.
4. What sample type is required and how is it collected?
A peripheral whole blood sample (5โ10 mL in an EDTA tube) is required. Collection is performed by our certified phlebotomy team. VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection is available daily from 8 AM to 11 PM.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework
DNA Labs UAE operates under DHA Facility License Number 1143 and strictly adheres to all applicable UAE federal data protection and health information regulations.
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): All patient genomic data and personal identifiers are processed, stored, and transmitted in full compliance with PDPL requirements for consent, data minimisation, and breach notification.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Electronic health records and genetic test results are managed within a secure ICT infrastructure that meets mandated cybersecurity and interoperability standards.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: Clinical oversight and patient consent protocols for genetic testing align with the medical liability framework, ensuring that pre-test counselling and post-test disclosure follow established standards of care.
Our laboratory is ISO 15189 accredited and participates in external quality assessment (EQA) schemes to maintain the highest standards of diagnostic accuracy and patient safety.
Clinical & Logistical Metadata
| Test Name | HCN2 Gene Epilepsy Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next Generation Sequencing (NGS) โ Full gene coverage including deep intronic regions |
| ICD-10-CM Code | G40.89 |
| LOINC Code | 94646-6 |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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