Test Price
2,800 AED✅ Home Collection Available
ZFPM2 Gene Tetralogy of Fallot Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Certified NGS processing according to DHA/MOHAP standards.
- ✓ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- ✓ Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a DHA-licensed genetic counsellor.
- ✓ Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The ZFPM2 Gene Tetralogy of Fallot Genetic Test is a comprehensive molecular assay that screens for pathogenic and likely pathogenic variants in the ZFPM2 gene using high-throughput Next‑Generation Sequencing. It provides definitive evidence for inherited Tetralogy of Fallot (TOF) and guides familial risk assessment, reproductive planning, and personalised surgical management.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Method | Next‑Generation Sequencing (Illumina NovaSeq X) | Sanger Sequencing (targeted, one exon at a time) |
| Variant Detection | Whole‑gene coverage, novel variants, CNVs | Only known hotspot mutations |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks (if multiple regions) |
| Clinical Sensitivity | ~99.9% | ~80–85% (misses deep intronic variants) |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics specialist, I recognise the profound implications a molecular diagnosis of Tetralogy of Fallot carries for a family. The ZFPM2 NGS test delivers exceptional accuracy for identifying causative variants, yet it must be integrated with a complete cardiological evaluation and three-generation pedigree analysis. A negative result does not eliminate other genetic or environmental contributors, and any alteration to a prescribed medical regimen requires direct physician oversight.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Important Advisory
Do not discontinue prescribed medication or alter your treatment plan without consulting your doctor.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Patients who have already undergone corrective cardiac surgery without prior genetic counselling; unaccompanied minors without signed consent as per UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Red Flag – Seek Emergency Care Immediately: New onset cyanosis (bluish skin), severe shortness of breath, syncope, or chest pain during or after sample collection.
Patient FAQ & Clinical Guidance
1. What is the ZFPM2 gene Tetralogy of Fallot NGS test, and why is it ordered?
This is a high-sensitivity genetic test that analyses the ZFPM2 gene for variants causing Tetralogy of Fallot, a congenital heart defect. It is typically requested by cardiologists or clinical geneticists when there is a personal or family history of TOF, to confirm a molecular diagnosis, assess recurrence risk in future pregnancies, or guide treatment planning. The test uses a blood or DNA sample and is processed in an ISO 9001:2015 certified laboratory, requiring 3–4 weeks for results.
2. How is the test performed and what are the pre-test requirements?
A certified phlebotomist performs a home collection of a single blood sample or an FTA card spot, which is then transported in a cold‑chain container. Prior to testing, you must provide a detailed clinical history and, ideally, attend a genetic counselling session to draw a pedigree chart outlining any affected family members. No fasting is required. The sample is processed using Illumina Next‑Generation Sequencing, covering all coding exons and splice sites, with variants classified according to ACMG 2025 guidelines.
3. What does a positive result mean for me and my family?
A positive result indicates identification of a disease‑causing variant in ZFPM2, confirming an inherited predisposition to Tetralogy of Fallot. It does not guarantee that you or your child will develop the condition, but it significantly increases the risk and mandates specialised imaging such as fetal echocardiography for pregnant relatives, and cascade testing for at‑risk family members. Genetic counselling is provided post‑test to explain inheritance (autosomal dominant with variable expressivity) and reproductive options including PGD.
UAE Regulatory & Data Privacy Adherence
All clinical data and genetic results are processed and stored in full compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – governing the collection, processing, and transfer of personal health data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – regulating digital health records and telemedicine practices.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – ensuring informed consent protocols and clinical safety standards.
Your genetic information remains confidential and accessible only to authorised healthcare professionals directly involved in your care.
Clinical & Logistical Metadata
| Test Name | ZFPM2 Gene Tetralogy of Fallot NGS Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21–28 Business Days (3–4 Weeks) |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Methodology Used | Next‑Generation Sequencing (Illumina NovaSeq X) |
| ICD-10-CM Code | Q21.3 |
| LOINC Code | 82332-1 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians