Test Price
2,800 AED✅ Home Collection Available
TGFB2 Gene Loeys-Dietz Syndrome Type 4 Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Next-Generation Sequencing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Consultation with a Consultant Medical Genetics.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- Turnaround Time: 3 to 4 Weeks from sample receipt.
- Price: 2,800 AED (includes home collection, laboratory analysis, and genetic counselling).
Test Overview & Methodology
This advanced next-generation sequencing (NGS) test comprehensively analyses the TGFB2 gene for pathogenic variants causing Loeys-Dietz syndrome type 4, a severe inherited connective tissue disorder that predisposes individuals to aortic aneurysms, arterial tortuosity, and early-onset vascular crises. The test uses targeted capture and high-depth sequencing to detect single nucleotide variants, insertions, deletions, and copy number changes across the entire coding region and flanking intronic sequences.
| Feature | Our NGS TGFB2 Test | Standard Single-Gene Sequencing |
|---|---|---|
| Methodology | Next Generation Sequencing (NGS) | Sanger Sequencing |
| Analytical Sensitivity | 99.9% (detects all variant types) | ~95% (limited to known hotspots) |
| Turnaround Time | 3 to 4 Weeks | 6 to 8 Weeks |
| Sample Types Accepted | Blood (whole), Extracted DNA, FTA Card | Blood only |
| Price | 2,800 AED | 1,500 – 2,200 AED |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403) notes:
“Genetic testing for Loeys-Dietz syndrome type 4 is a powerful step toward personalized cardiovascular care. The TGFB2 NGS assay provides high-resolution variant detection, but it is essential to interpret results in the context of a detailed clinical examination, family history, and imaging findings. I always recommend discussing the implications with a genetic counsellor and a cardiologist experienced in aortopathy management before making any treatment decisions.”
Important Medication Advisory
⚠️ Do not discontinue any prescribed medications such as beta‑blockers or angiotensin receptor blockers (ARBs) without consulting your doctor. Genetic testing supplements, but does not replace, ongoing clinical surveillance and pharmacotherapy for aortic risk management.
Exclusion Criteria & Emergency Red Flags
- Testing of asymptomatic minors without thorough pre‑test genetic counselling and documented parental/legal guardian consent, in strict compliance with Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Individuals unable to provide informed consent or who lack the psychological readiness to receive potentially life‑altering genetic information.
- Acute illness, recent blood transfusion (within 3 weeks), or current chemotherapy may affect test quality – our clinical team will assess suitability.
🚨 If you experience sudden, severe chest, back, or abdominal pain, difficulty breathing, fainting, or signs of a stroke, seek emergency medical care immediately. Do not wait for your genetic test results.
Patient FAQ & Clinical Guidance
1. What is the purpose of the TGFB2 gene test?
This NGS test detects mutations in the TGFB2 gene that cause Loeys-Dietz syndrome type 4, providing a molecular diagnosis that guides personalized cardiovascular surveillance and management. It is recommended for individuals with a personal or family history of aortic root enlargement, early‑onset arterial aneurysms, or suspected Loeys‑Dietz spectrum disorders. A positive result clarifies the diagnosis and directs tailored monitoring, while a negative result may still require continued clinical vigilance if suspicion remains high.
2. How should I prepare and what sample is needed?
No fasting or special preparation is required. The test can be performed on a standard venous blood draw (3–5 mL in EDTA tube), a previously extracted DNA sample (stored appropriately), or a single drop of blood applied to an FTA card. Our DHA-licensed mobile phlebotomist will collect the sample at your home using temperature-controlled cold-chain transport. Please inform us if you have received a blood transfusion within the last three weeks or are undergoing active chemotherapy.
3. When will I receive my results and who will explain them?
Results are available within 3 to 4 weeks from sample receipt. You will receive a comprehensive written report detailing any identified variants, their clinical significance, and recommended follow‑up. A Consultant Medical Genetics will contact you by telephone at a pre‑arranged time to interpret the findings, discuss implications for your health and family members, and outline next steps such as referral to a cardiologist or clinical geneticist.
4. Is home collection available for this test?
Yes, VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection is available daily from 8:00 AM to 11:00 PM, including weekends. Our trained phlebotomist will visit your residence anywhere in the UAE to collect the appropriate sample, ensuring specimen integrity throughout transport to the ISO‑accredited laboratory.
UAE Regulatory & Data Privacy Adherence
Regulatory Framework
- Data Protection: All personal and genetic data are handled in accordance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Information: Compliance with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields ensures secure electronic storage and transfer of medical records.
- Clinical Safety: Patient consent and safety protocols adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- ISO Certification: Laboratory processes are ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139), guaranteeing continuous quality improvement.
For booking or inquiries, contact our support team via WhatsApp +971 54 548 8731.
Clinical & Logistical Metadata
| Test Name | TGFB2 Gene Loeys-Dietz Syndrome Type 4 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, FTA Card |
| Methodology Used | Next Generation Sequencing (NGS) |
| ICD-10-CM Code | Q87.89 |
| LOINC Code | 44127-1 |
| DHA Facility License & Laboratory Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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