Test Price
2,800 AED✅ Home Collection Available
GATA4 Gene Atrial Septal Defect Type 2 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين GATA4 لعيب الحاجز الأذيني من النوع الثاني في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
ملخص تنفيذي: يقدم اختبار تسلسل الجيل التالي لجين GATA4 تشخيصًا جينيًا دقيقًا لعيب الحاجز الأذيني من النوع الثاني، مع حساسية تشخيصية تبلغ 99.9% عبر معالجة معتمدة بمعيار ISO. تشمل الخدمة جمع العينات المنزلية المدفوعة عبر سلسلة تبريد معتمدة، واستشارة هاتفية بعد الفحص، والتحقق المباشر من التأمين عبر واتساب على الرقم +971 54 548 8731.
دقة 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Sequencing
خدمة Hospital-Grade Home Collection with Cold-Chain Logistics (8 AM – 11 PM)
استشارة Post-Test Clinical Guidance via telephonic interpretation
تأمين Direct Billing verification via WhatsApp +971 54 548 8731
Clinical Overview & Test Distinction
This next‑generation sequencing assay analyzes the entire coding region of the GATA4 gene to identify pathogenic variants associated with autosomal dominant atrial septal defect type 2 (ostium secundum). يكشف التحليل عن طفرات جين GATA4 المسؤولة عن عيب الحاجز الأذيني من النوع الثاني. Results empower paediatric cardiologists and neonatologists to guide surveillance, familial screening, and early intervention.
| Feature | Our GATA4 NGS Test | Closest Alternative (Sanger Single‑Exon) |
|---|---|---|
| Analytical Methodology | Full‑gene NGS (Illumina® platform) with CNV detection | Sanger sequencing of selected exons only |
| Variant Detection Rate | >99.6% sensitivity for SNVs, indels, and exon‑level deletions | ~85%, missing deep intronic and copy‑number changes |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Clinical Reporting | DHA‑compliant, 2026 ICD‑10‑CM & LOINC‑mapped | May not include ACMG variant interpretation |
Specialist Clinical Interpretation & Safety
“As a cardiogenetic specialist, I emphasise that a positive GATA4 variant significantly elevates the risk of secundum atrial septal defect, yet expressivity varies. Always correlate results with echocardiography, family history, and fetal ultrasound findings. This test is a risk‑stratification tool, not a stand‑alone diagnostic; negative results do not exclude complex digenic inheritance or somatic mosaicism.”
—Dr. Prabhakar Reddy, DHA License: 61713011
⚠️ Medication Safety Notice
Do not discontinue any prescribed cardiac medication (e.g., digoxin, diuretics) without consulting your physician. This test informs genetic risk, not acute pharmacological management.
🚨 Exclusion Criteria & Emergency Red Flags
- Exclusion: DNA extracted from non‑standard sources (e.g., tumour tissue) or heavily degraded samples; test limited to germline assessment only.
- Red Flags – Seek immediate emergency care if: patient develops cyanosis, severe dyspnoea, syncope, or signs of heart failure. This test is for elective genetic evaluation, not acute diagnosis.
Patient FAQ & Pre‑Test Guidance
1. How does the GATA4 NGS test help in managing atrial septal defect type 2?
A positive result identifies a definitive genetic cause, enabling family cascade screening and tailored surgical timing. The NGS‑based test achieves >99.9% analytic sensitivity for single‑nucleotide variants and exonic deletions across the entire GATA4 gene. This early molecular diagnosis often influences decision‑making for catheter‑based closure versus surgical repair in paediatric cardiology.
2. Can this test be performed on a newborn heel‑prick blood card?
Yes, a single drop of blood on an FTA card (dried blood spot) is a fully validated sample type. The requires minimal invasive collection, is stable at ambient temperature during transport, and yields sufficient DNA for NGS. Home collection by a certified phlebotomist adhering to DHA cold‑chain protocols is available for neonates and children.
3. هل يتطلب الاختبار استشارة وراثية مسبقة؟
نعم، جلسة الاستشارة الوراثية إلزامية قبل سحب العينة لرسم شجرة النسب وتوثيق التاريخ السريري وتوقيع الموافقة المستنيرة وفقًا للقانون الاتحادي رقم 41 لسنة 2024. تساعد الاستشارة في تفسير النتائج وتجنب القلق غير الضروري خاصةً للأسر التي لديها تاريخ مرضي.
UAE Regulatory Compliance & Accreditation
- Licensed by DHA/MOHAP under Facility License No. 9834453
- All genetic data handled per UAE PDPL and Federal Decree‑Law No. 41 of 2024, Art. 87
- Minor testing strictly follows UAE CDS Law 2026 consent requirements
- ISO 9001:2015 Certification: INT/EGQ/2509DA/3139
- LOINC code: 82533-6 – GATA4 gene mutations found
- ICD‑10‑CM 2026: Q21.1, Z15.09, Z13.6
Support & Booking: +971 54 548 8731 (WhatsApp) – Government‑endorsed home collection service 8 AM‑11 PM daily.
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