Test Price
2,800 AED✅ Home Collection Available
AGK Gene NGS Test for Sengers Syndrome – Molecular Diagnosis & Family Risk Assessment
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity for pathogenic variants via ISO 15189 accredited next‑generation sequencing.
- Premium Logistics: VIP mobile phlebotomy and temperature‑controlled cold‑chain home collection available daily 8 AM–11 PM.
- Clinical Guidance: Mandatory pre‑test genetic counselling with a consultant medical geneticist; post‑test telephonic interpretation support.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This assay employs next‑generation sequencing (NGS) of the entire AGK gene, including flanking intronic regions, to detect single‑nucleotide variants, small insertions/deletions, and copy‑number variations that cause Sengers syndrome. The test is performed on peripheral whole blood and requires a compulsory genetic counselling session prior to sampling to construct a three‑generation pedigree and ensure accurate variant interpretation.
| Feature | DNA Labs UAE AGK NGS | Standard Sanger Sequencing |
|---|---|---|
| Methodology | NGS – full gene + intronic regions | Sanger – selected exons only |
| Coverage | 100% coding exons ±20 bp flanking | Limited to targeted exons |
| Sensitivity | 99.9% for point mutations & indels | ~95% |
| Turnaround Time | 3–4 weeks | 4–6 weeks |
| Price | 2,800 AED | Often higher due to limited analysis |
Physician Insight & Safety Protocols
Pre‑Test Advisory
Genetic testing for Sengers syndrome must be accompanied by a mandatory counselling session prior to sample collection. Do not discontinue any current medications without consulting your referring physician. If you are on anticoagulant therapy, please inform the phlebotomist before the blood draw.
Exclusion Criteria & Red Flags
- Active acute infection or fever – postpone collection until clinically stable.
- Inability to provide informed consent (legal guardian required for minors as per Federal Decree‑Law No. 4 of 2016 on Medical Liability).
- Severe hemodynamic instability requiring immediate emergency care.
- Contraindication to venipuncture: severe coagulopathy without medical clearance.
- Test not indicated for asymptomatic individuals without family history or clinical suspicion of Sengers syndrome – consult a genetic counsellor first.
If the patient experiences chest pain, syncope, severe shortness of breath, or palpitations before or after sample collection, seek emergency medical attention immediately.
Patient FAQ & Clinical Guidance
1. What is the purpose of the AGK gene NGS test?
This test sequences the entire AGK gene to identify pathogenic variants that cause Sengers syndrome, a rare mitochondrial disorder characterised by hypertrophic cardiomyopathy, congenital cataracts, and myopathy. A precise genetic diagnosis enables accurate family risk assessment and cascade testing.
2. How is the sample collected and what are the requirements?
A peripheral blood sample (3–5 mL in EDTA tube) is collected by a licensed phlebotomist during a VIP mobile home visit or at our Dubai Healthcare City facility. Temperature‑controlled cold‑chain transport preserves sample integrity. No fasting is required, but please inform our team of any anticoagulant use.
3. What do the results mean for my family?
A positive result confirms Sengers syndrome in the tested individual and allows at‑risk relatives to undergo targeted variant testing. Genetic counselling is mandatory before and after testing to explain autosomal recessive inheritance, reproductive risks, and management recommendations.
4. How long does it take to get results?
The turnaround time is 3–4 weeks from sample receipt. This includes DNA extraction, library preparation, NGS sequencing, bioinformatic analysis, and clinical variant interpretation by our consultant medical geneticist.
UAE Regulatory & Data Privacy Adherence
Data Privacy: All genetic data is processed and stored in compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Patient Safety & Consent: Informed consent and medical liability are governed by Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Accreditation: Testing performed at an ISO 9001:2015 certified facility (Cert: INT/EGQ/2509DA/3139) and ISO 15189 accredited molecular genetics laboratory. Home collection license: 9834453.
Clinical & Logistical Metadata
| Test Name | AGK Gene NGS Test for Sengers Syndrome |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) – VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection |
| Methodology Used | Next‑generation sequencing (NGS) – full gene analysis |
| ICD-10-CM Code | E88.4, E88.49 |
| LOINC Code | 21641-0 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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