Test Price
2,800 AED✅ Home Collection Available
FOXH1 Gene – Congenital Heart Disease & Transposition of the Great Arteries Genetic Test in UAE
تحليل جين FOXH1 لأمراض القلب الخلقية وتبدل الشرايين الكبيرة في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary & Patient Assurance
Diagnostic Accuracy: 99.9% Sensitivity
ISO 9001:2015 accredited processing (Cert: INT/EGQ/2509DA/3139). NGS technology delivers comprehensive coding region coverage with single-nucleotide variant resolution for the FOXH1 gene locus (8q24.3).
Premium Logistics: ISO-Certified Cold-Chain Home Collection
Hospital-grade phlebotomy dispatched to your residence (8 AM – 11 PM). VIP mobile service available across all seven emirates with temperature-controlled transport at 2–8°C. Acceptable specimens: Whole Blood (EDTA), Extracted DNA, or FTA Card.
Post-Test Clinical Guidance
Telephonic interpretation session with a qualified genetic counsellor following result delivery. استشارة طبية هاتفية بعد الفحص لتفسير النتائج
Direct Insurance Billing Verification
WhatsApp your insurance card to +971 54 548 8731 for real-time coverage confirmation. تحقق من تغطية التأمين عبر واتساب
Clinical Test Overview
The FOXH1 Gene Genetic Test is a targeted next-generation sequencing assay designed to detect pathogenic variants within the FOXH1 gene associated with congenital heart disease (CHD) and transposition of the great arteries (TGA). This test is indicated for neonatal and paediatric patients presenting with dysmorphological features and suspected cardiogenetic aetiology. اختبار جيني متقدم للكشف عن الطفرات المسببة لأمراض القلب الخلقية وتبدل الشرايين الكبيرة لدى الأطفال وحديثي الولادة.
| Parameter | Our Test (DHA-Certified) | Closest Alternative |
|---|---|---|
| Platform | NGS (Next Generation Sequencing) | Sanger Sequencing / Panel-Based |
| Coverage | Full Coding Region + Splice Sites | Selected Exons Only |
| Variant Detection | SNVs, Indels, CNVs (High Resolution) | SNVs & Small Indels Only |
| TAT | 3–4 Weeks | 6–8 Weeks |
| ISO Accreditation | ISO 9001:2015 Certified | Variable / Non-Certified |
Physician Insight & Safety Protocol
Clinical Note from Dr. Prabhakar Reddy (DHA License: 61713011): "The FOXH1 gene encodes a forkhead transcription factor critical for cardiac morphogenesis during embryonic development; pathogenic variants are strongly associated with laterality defects and outflow tract malformations. I emphasise that this genetic result must be correlated with echocardiographic findings and comprehensive paediatric cardiology evaluation. A positive result informs clinical management but does not replace surgical planning for transposition correction."
⚠ Medication Warning:
Do not discontinue any prescribed cardiac or anticoagulant medication without consulting your supervising physician. Genetic test results are diagnostic adjuncts, not therapeutic directives.
Exclusion Criteria & Emergency Red Flags
Specimen Exclusion Criteria:
- Haemolysed blood samples (free haemoglobin > 50 mg/dL)
- Clotted specimens in EDTA tubes
- Insufficient DNA yield (< 50 ng/μL post-extraction)
- FTA cards with visible mould or moisture damage
- Samples collected outside sterile protocol (contaminated)
Emergency Red Flags – Seek Immediate Medical Attention:
- Neonatal cyanosis unresponsive to oxygen therapy
- Respiratory distress with SpO₂ < 85%
- Signs of cardiogenic shock in infant (pallor, weak pulses, hypotension)
- Acute altered consciousness in paediatric patient
- seizures or hypoxic-ischaemic events
This genetic test is an elective diagnostic investigation. It is not a substitute for emergency medical evaluation. In case of any of the above red flags, proceed directly to the nearest emergency department.
Pre-Test Requirements & Preparation
- ● Clinical History Documentation: A detailed clinical history of the patient is mandatory, including echocardiographic findings, cardiac MRI reports (if available), and documentation of any prior surgical interventions for congenital heart defects.
- ● Genetic Counselling Session: A pre-test genetic counselling session is required to construct a comprehensive three-generation pedigree chart identifying all family members affected by FOXH1-associated congenital heart disease or transposition of the great arteries. جلسة استشارة وراثية قبل الفحص لرسم شجرة العائلة
- ● Informed Consent: Written informed consent must be obtained prior to sample collection, in compliance with UAE Federal Decree-Law No. 41 of 2024 (Article 87) and UAE PDPL data privacy regulations.
- ● Minors Protocol (CDS Law 2026): For paediatric patients and minors, parental or legal guardian consent is legally mandated. Genetic testing of minors strictly requires documented clinical indication.
- ● Sample Collection Note: No specific drug or supplement discontinuation is required prior to blood draw. The test analyses germline DNA, which is unaffected by pharmacological agents. Standard phlebotomy fasting is not required unless concurrent biochemical testing is ordered.
Patient FAQ & Clinical Guidance
What does the FOXH1 gene test diagnose, and how accurate is it for transposition of the great arteries?
The FOXH1 Genetic Test identifies pathogenic variants in the forkhead box H1 gene with 99.9% diagnostic sensitivity, detecting single nucleotide variants, small insertions/deletions, and copy number changes associated with congenital heart disease including transposition of the great arteries. يكشف هذا الاختبار الطفرات الجينية في جين FOXH1 المرتبطة بتبدل الشرايين الكبيرة بدقة تشخيصية تصل إلى 99.9%. The test sequences the entire coding region of FOXH1 using next-generation sequencing technology, providing clinicians with a comprehensive variant profile that informs surgical planning, family screening, and recurrence risk counselling.
How long do results take, and how much does the FOXH1 genetic test cost in the UAE?
The FOXH1 gene NGS test delivers comprehensive results within 3 to 4 weeks at a total cost of 2800 AED, inclusive of hospital-grade home collection, ISO-certified cold-chain transport, and post- telephonic clinical guidance for result interpretation. تظهر نتائج الاختبار خلال 3 إلى 4 أسابيع بتكلفة 2800 درهم تشمل السحب المنزلي والاستشارة الطبية. Direct insurance billing verification is available via WhatsApp at +971 54 548 8731; many UAE insurers cover genetic testing for congenital heart disease when supported by a paediatric cardiologist referral.
Is home sample collection available for paediatric patients across all UAE emirates?
Yes, we provide ISO-certified paediatric home phlebotomy services across all seven emirates from 8 AM to 11 PM, with specially trained paediatric phlebotomists experienced in neonatal and infant blood collection using micro-collection techniques for minimal discomfort. خدمة سحب الدم المنزلي للأطفال متوفرة في جميع الإمارات السبع من الثامنة صباحاً حتى الحادية عشرة مساءً. Acceptable sample types include whole blood in EDTA tubes, extracted DNA, or a single drop of blood on an FTA card, providing flexibility for fragile paediatric veins and remote collection scenarios.
Regulatory Compliance & Legal Framework
UAE Federal Decree-Law No. 41 of 2024
Article 87: Genetic testing consent and data protection mandates for UAE healthcare providers.
CDS Law 2026 – Minors Protection
Genetic testing of minors requires documented clinical indication and guardian consent per UAE Communicable Diseases Law amendments.
UAE PDPL Compliance
All genetic data is processed and stored in compliance with the UAE Personal Data Protection Law with end-to-end encryption.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians