Test Price
2,800 AED✅ Home Collection Available
FOXH1 Gene – Congenital Heart Disease & Transposition of the Great Arteries Genetic Test in UAE
Executive Summary & Core Metrics
Executive Summary & Patient Assurance
Diagnostic Accuracy: 99.9% Sensitivity
ISO 9001:2015 accredited processing (Cert: INT/EGQ/2509DA/3139). NGS technology delivers comprehensive coding region coverage with single-nucleotide variant resolution for the FOXH1 gene locus (8q24.3).
Premium Logistics: VIP Mobile Phlebotomy & Cold-Chain Home Collection
Hospital-grade phlebotomy dispatched to your residence (8 AM – 11 PM). VIP mobile service available across all seven emirates with temperature-controlled transport at 2–8°C. Acceptable specimens: Whole Blood (EDTA), Extracted DNA, or FTA Card.
Post-Test Clinical Guidance
Telephonic interpretation session with a qualified genetic counsellor following result delivery to explain variant implications, inheritance patterns, and family screening recommendations.
Direct Insurance Billing Verification
WhatsApp your insurance card to +971 54 548 8731 for real-time coverage confirmation. Direct billing available for major UAE insurers supporting genetic diagnostics.
Test Overview & Methodology
The FOXH1 Gene Genetic Test is a targeted next-generation sequencing assay designed to detect pathogenic variants within the FOXH1 gene associated with congenital heart disease (CHD) and transposition of the great arteries (TGA). This test is indicated for neonatal and paediatric patients presenting with dysmorphological features and suspected cardiogenetic aetiology. The FOXH1 gene encodes a forkhead transcription factor critical for cardiac morphogenesis during embryonic development; pathogenic variants are strongly associated with laterality defects and outflow tract malformations.
| Parameter | Our Test (DHA-Certified) | Closest Alternative |
|---|---|---|
| Platform | NGS (Next Generation Sequencing) | Sanger Sequencing / Panel-Based |
| Coverage | Full Coding Region + Splice Sites | Selected Exons Only |
| Variant Detection | SNVs, Indels, CNVs (High Resolution) | SNVs & Small Indels Only |
| TAT | 3–4 Weeks | 6–8 Weeks |
| ISO Accreditation | ISO 9001:2015 Certified | Variable / Non-Certified |
Physician Insight & Safety Protocols
Clinical Note from Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403): "The FOXH1 gene encodes a forkhead transcription factor critical for cardiac morphogenesis during embryonic development; pathogenic variants are strongly associated with laterality defects and outflow tract malformations. I emphasize that this genetic result must be correlated with echocardiographic findings and comprehensive paediatric cardiology evaluation. A positive result informs clinical management, family screening, and recurrence risk counselling but does not replace surgical planning for transposition correction."
Advisory: Medication and Clinical Management
⚠ Medication Warning:
Do not discontinue any prescribed cardiac or anticoagulant medication without consulting your supervising physician. Genetic test results are diagnostic adjuncts designed to inform clinical care, not standalone directives for therapeutic change.
Exclusion Criteria & Emergency Red Flags
Specimen Exclusion Criteria:
- Haemolysed blood samples (free haemoglobin > 50 mg/dL)
- Clotted specimens in EDTA tubes
- Insufficient DNA yield (< 50 ng/μL post-extraction)
- FTA cards with visible mould or moisture damage
- Samples collected outside sterile protocol (contaminated)
Emergency Red Flags – Seek Immediate Medical Attention:
- Neonatal cyanosis unresponsive to oxygen therapy
- Respiratory distress with SpO₂ < 85%
- Signs of cardiogenic shock in infant (pallor, weak pulses, hypotension)
- Acute altered consciousness in paediatric patient
- Seizures or hypoxic-ischaemic events
This genetic test is an elective diagnostic investigation. It is not a substitute for emergency medical evaluation. In case of any of the above red flags, proceed directly to the nearest emergency department.
Patient FAQ & Clinical Guidance
1. What does the FOXH1 gene test diagnose, and how accurate is it for transposition of the great arteries?
The FOXH1 Genetic Test identifies pathogenic variants in the forkhead box H1 gene with 99.9% diagnostic sensitivity, detecting single nucleotide variants, small insertions/deletions, and copy number changes associated with congenital heart disease including transposition of the great arteries. The test sequences the entire coding region of FOXH1 using next-generation sequencing technology, providing clinicians with a comprehensive variant profile that informs surgical planning, family screening, and recurrence risk counselling.
2. How long do results take, and how much does the FOXH1 genetic test cost in the UAE?
The FOXH1 gene NGS test delivers comprehensive results within 3 to 4 weeks at a total cost of 2800 AED, inclusive of VIP mobile phlebotomy, ISO-certified cold-chain transport, and post-test telephonic clinical guidance for result interpretation. Direct insurance billing verification is available via WhatsApp at +971 54 548 8731; many UAE insurers cover genetic testing for congenital heart disease when supported by a paediatric cardiologist referral.
3. Is home sample collection available for paediatric patients across all UAE emirates?
Yes, we provide ISO-certified paediatric VIP mobile phlebotomy services across all seven emirates from 8 AM to 11 PM, with specially trained paediatric phlebotomists experienced in neonatal and infant blood collection using micro-collection techniques for minimal discomfort. Acceptable sample types include whole blood in EDTA tubes, extracted DNA, or a single drop of blood on an FTA card, providing flexibility for fragile paediatric veins and remote collection scenarios.
UAE Regulatory & Data Privacy Adherence
Legal Framework & Data Protection
Federal Decree-Law No. 45 of 2021 (PDPL)
All genetic data is processed and stored in full compliance with the UAE Personal Data Protection Law, ensuring end-to-end encryption, explicit patient consent, and strict access controls for genetic information.
Federal Law No. 2 of 2019 (ICT Health)
Health information systems and digital diagnostic platforms adhere to the highest standards for the use of information and communication technology in health fields, safeguarding data integrity and cybersecurity.
Federal Decree-Law No. 4 of 2016 (Medical Liability)
Clinical safety, pre-test genetic counselling protocols, and informed consent frameworks strictly follow this decree, ensuring comprehensive patient rights protection and clinical accountability.
Clinical & Logistical Metadata
| Test Name | FOXH1 Gene Genetic Test |
| Price (AED) | 2800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | Q20.3, Q24.9 |
| LOINC Code | 103206-3 |
| DHA Facility License & Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians