Test Price
2,800 AED✅ Home Collection Available
SDHAF2 Gene (Hereditary Paraganglioma-Pheochromocytoma Type 5) Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
High-Resolution Genetic Analysis for SDHAF2 Mutation Detection
- Analytical Accuracy: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited process.
- Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM–11 PM.
- Medical Guidance: Post-test teleconsultation for clinical result interpretation.
- Insurance: Direct coverage check via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The SDHAF2 NGS test screens for germline mutations in the SDHAF2 gene, the primary cause of hereditary paraganglioma-pheochromocytoma syndrome type 5 (PGL5). This advanced genetic analysis is essential for at‑risk individuals, enabling early surveillance and personalized prevention of neuroendocrine tumors.
| Feature | Our Test (DNA Labs UAE) | Closest Alternative |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) with full gene coverage & bioinformatics | Single-gene Sanger sequencing (limited regions) |
| Diagnostic Precision | 99.9% analytical sensitivity for SNVs, indels | Lower sensitivity for mosaic variants |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| UAE Compliance | Full DHA/MOHAP standards, ISO 9001:2015 | May lack local accreditation |
Physician Insight & Safety Protocols
“Your genetic report reveals predisposition, not an active tumor. I always interpret SDHAF2 results alongside your clinical history and family pedigree; we will navigate the next steps together with compassion and clinical precision.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Do Not Discontinue Prescribed Medications
⚠️ Do not discontinue or modify any prescribed medication (particularly antihypertensives or beta‑blockers) without consulting your physician. A sudden withdrawal can provoke a life‑threatening catecholamine crisis.
Exclusion Criteria & Emergency Red Flags
- Not recommended for: Individuals without a documented family history of paraganglioma/pheochromocytoma or personal clinical suspicion; testing in minors requires legal guardian consent under UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.
- ER Red Flags: Sudden severe hypertension, pounding headache, palpitations, excessive sweating, or pallor. These symptoms may signal a catecholamine‑secreting tumor crisis — seek emergency care immediately.
- Pre‑test requirement: Mandatory genetic counselling and pedigree drawing before sample collection.
Patient FAQ & Clinical Guidance
1. What conditions does the SDHAF2 NGS test detect?
Key Insight: The test identifies SDHAF2 gene mutations causing hereditary paraganglioma‑pheochromocytoma type 5, increasing the risk of head/neck paragangliomas and adrenal pheochromocytomas.
The NGS panel screens all coding regions of the SDHAF2 gene, detecting single nucleotide variants, small insertions/deletions, and copy number changes, providing a comprehensive risk profile.
2. Who should consider this genetic test?
Key Insight: Individuals with a personal or family history of early‑onset paraganglioma, multiple head/neck tumors, or bilateral pheochromocytoma should undergo SDHAF2 testing.
Clinical guidelines by DHA recommend testing for first‑degree relatives of a known SDHAF2 mutation carrier, even in the absence of symptoms, to guide surveillance.
3. How accurate is this genetic test?
Key Insight: Analytical sensitivity reaches 99.9% due to Next-Generation Sequencing technology, validated under our DHA-accredited laboratory standards.
Every positive result is confirmed by re‑sequencing and interpreted according to the American College of Medical Genetics classification, ensuring complete reliability of the report.
UAE Regulatory & Data Privacy Adherence
Data Protection & Clinical Governance
All genetic data processing strictly follows Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your genetic information is treated with the highest confidentiality and used solely for clinical diagnosis and treatment planning.
DNA Labs UAE is fully compliant with Dubai Health Authority (DHA) licensing requirements for genetic testing and holds ISO 9001:2015 certification for quality management.
Clinical & Logistical Metadata
| Test Name | SDHAF2 Gene (Hereditary Paraganglioma-Pheochromocytoma Type 5) Genetic Test – NGS |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) |
| Methodology Used | Next-Generation Sequencing (NGS) with full gene coverage & bioinformatics analysis |
| ICD-10-CM Code | Z15.09 |
| LOINC Code | 100218-4 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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