Test Price
2,000 AED✅ Home Collection Available
Microsatellite Instability (MSI) Testing for Lynch Syndrome & Colorectal Cancer in Dubai | 2,000 AED
Executive Summary & Core Metrics
Clinical Precision & UAE Regulatory Assurance
Microsatellite instability (MSI) testing is a genetic assay that detects defective DNA mismatch repair (dMMR), the primary marker for Lynch syndrome and hereditary colorectal cancer. All samples are processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, ensuring strict adherence to DHA standards.
Test Overview & Methodology
Microsatellite instability (MSI) testing identifies defective DNA mismatch repair (dMMR) associated with Lynch syndrome and colorectal cancer prognosis. This method uses fluorescent multiplex PCR followed by capillary electrophoresis fragment analysis to directly detect genomic instability.
| Feature | Our MSI Test (Fragment Analysis) | Standard IHC (MMR Protein Staining) |
|---|---|---|
| Methodology | Fluorescent Multiplex PCR + Capillary Electrophoresis Fragment Analysis | Immunohistochemistry (IHC) staining of MLH1, MSH2, MSH6, PMS2 |
| Diagnostic Precision | 99.9% Sensitivity; detects genomic instability directly | ~90–95% Sensitivity; may miss MSH6 mutations or protein‑neutral variants |
| Report TAT | 7–8 business days | 3–5 days (less comprehensive) |
| Clinical Utility | Gold standard for Lynch syndrome screening and 5‑FU therapy decision | Preliminary screen; often requires confirmatory MSI/PCR |
Physician Insight & Safety Protocols
"Understanding the molecular profile of your tumor through MSI testing provides invaluable guidance for both hereditary cancer risk assessment and treatment selection. As a consultant in medical genetics, I emphasize that this result must be integrated with your complete clinical history and family pedigree."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Protocol
Do not discontinue any prescribed medication without consulting your doctor. If you experience sudden severe abdominal pain, large-volume rectal bleeding, or signs of intestinal obstruction, proceed to the nearest emergency department regardless of pending test results.
Exclusion Criteria
- Inadequate or degraded tumor tissue block
- Inability to obtain a matched peripheral blood sample
- Active coagulopathy that increases risk during specimen collection
Patient FAQ & Clinical Guidance
1. Why is MSI testing crucial for Lynch syndrome?
MSI testing determines if your tumor has DNA repair defects, guiding surveillance and immunotherapy decisions. This result must be interpreted in the context of your family history by a genetics specialist.
2. How is the sample collected?
Our DHA-licensed team coordinates secure courier retrieval of your archived tumor tissue block from the hospital pathology department. A separately scheduled blood sample collection is performed at our facility or via an approved diagnostic center.
3. How do I interpret my results?
Your results will indicate MSI-High, MSI-Low, or MSS (stable). A post-test telephonic consultation with our DHA-licensed genetic counsellor is included to explain the findings and recommend next steps.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance
Your genetic data is handled in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. All results are encrypted and accessible only to authorized medical professionals.
Clinical & Logistical Metadata
| Test Name | Microsatellite Instability (MSI) Testing |
| Price (AED) | 2,000 |
| Turnaround Time | 7–8 business days |
| Sample Type / Matrix | Archival Tumor Tissue Block (FFPE) and Peripheral Blood |
| Methodology Used | Fluorescent Multiplex PCR + Capillary Electrophoresis Fragment Analysis |
| ICD-10-CM Code | Z12.11, Z80.3 |
| LOINC Code | 59040-5 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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