Test Price
6,000 AED✅ Home Collection Available
TP53 Mutation Analysis (NGS) in UAE | 6000 AED | 2026 DHA Guidelines
تحليل طفرة جين TP53 بتقنية التسلسل الجيني من الجيل التالي في الإمارات | 6000 درهم | معتمد من هيئة الصحة بدبي
Executive Summary – ملخص تنفيذي
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited NGS processing with orthogonal Sanger confirmation.
- Premium Logistics: Hospital-grade home collection through ISO-certified cold‑chain transport and VIP mobile phlebotomy (8 AM‑11 PM).
- Clinical Guidance: Complimentary post‑test telephonic consultation to interpret results and plan next steps.
- Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
دقة تشخيصية تصل إلى 99.9% عبر معالجة معتمدة وفقًا للمواصفة القياسية الدولية ISO 9001:2015، مع جمع منزلي فاخر واستشارة سريرية بعد الفحص.
Clinical Overview
TP53 Mutation Analysis by Next‑Generation Sequencing (NGS) detects pathogenic germline and somatic variants in the TP53 tumour suppressor gene, the cornerstone of Li‑Fraumeni syndrome and hereditary cancer predisposition. This 15‑18‑day, DHA‑compliant assay delivers comprehensive coding‑region coverage and splice‑site analysis, empowering precision oncology in the UAE. يكشف هذا التحليل المتقدم عن طفرات جين TP53 المسؤولة عن متلازمة لي‑فروميني واستعداد الأورام، ويُجرى بمعايير هيئة الصحة بدبي.
| Feature | Our Test – NGS TP53 Analysis | Closest Alternative – Single‑Gene Sanger Sequencing |
|---|---|---|
| Technology | High‑coverage NGS (Illumina) with confirmatory Sanger for pathogenic calls | Sanger sequencing of selected exons only |
| Analytical Sensitivity | 99.9% for SNVs, small indels, and copy‑number changes | ~99% for point mutations, poor detection of large rearrangements |
| Turnaround Time | 15–18 days | 7–10 days (incomplete region analysis) |
| Clinical Relevance | Covers all ACMG‑recommended regions; Li‑Fraumeni syndrome & somatic profiling | Limited to hotspot exons; may miss clinically actionable mutations |
Physician Insight & Safety Protocol
“As a clinician, I understand that genetic testing can be emotionally challenging. This TP53 analysis is a powerful tool for personalised risk assessment, but results must be interpreted within your complete clinical picture and family history. Please discuss any findings with your referring oncologist or genetic counsellor.”
– Dr. Prabhakar Reddy, DHA License 61713011
⚠ Medication Warning
Do not discontinue prescribed medication without consulting your doctor.
Exclusion Criteria & Emergency Red Flags
- Pregnancy: requires prior specialist genetic counselling and written informed consent per UAE Federal Decree‑Law No. 41 of 2024.
- Acute febrile illness or recent blood transfusion (<2 weeks) may affect sample quality.
- Incomplete consent for genetic data storage under UAE PDPL – mandatory for all minors (CDS Law 2026).
- Seek immediate medical attention if you experience sudden severe bleeding, neurological changes, or intense pain unrelated to the blood draw; these are not test complications but require urgent evaluation.
Patient FAQ & Clinical Guidance
What is TP53 mutation analysis and why is it performed?
It detects inherited or acquired mutations in the TP53 tumour suppressor gene, essential for diagnosing Li‑Fraumeni syndrome and guiding cancer surveillance. The test analyses all coding exons using NGS, providing a definitive genetic risk assessment for multiple malignancies.
يكشف تحليل طفرة جين TP53 عن التغيرات الجينية المسؤولة عن متلازمة لي‑فروميني ويساعد في توجيه العلاج الوقائي للسرطان.
How is the sample collected for this?
A certified home‑care phlebotomist draws a small amount of blood or bone marrow aspirate; no fasting is required. The sample is immediately placed in a cold‑chain transport and reaches our ISO‑certified lab within 4 hours.
يتم سحب عينة دم بسيطة أو نخاع العظم بواسطة أخصائي مرخص في منزلك دون الحاجة للصيام، وتُنقل بتبريد خاص للمختبر.
When will I receive my results and how should they be interpreted?
Your comprehensive report is ready in 15‑18 days and includes a free telephonic consultation with a clinical expert. Results are classified according to ACMG guidelines; pathogenic variants are explained in the context of your personal and family history.
تصلك نتائجك الكاملة خلال 15‑18 يوماً مع استشارة هاتفية مجانية من خبير سريري لشرح النتائج حسب الإرشادات العالمية.
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians