Test Price
2,800 AED✅ Home Collection Available
RHBDF2 Gene Tylosis with Esophageal Cancer Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين RHBDF2 لمرض التَّيَلُّس مع سرطان المريء بتقنية التسلسل الجيني NGS في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
الملخص التنفيذي
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- ✓ Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy (8 AM – 11 PM).
- ✓ Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation with a DHA-licensed genetic consultant.
- ✓ Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Overview
This NGS-based test screens the entire coding region of the RHBDF2 gene for pathogenic variants linked to Tylosis with Esophageal Cancer syndrome (Howel-Evans syndrome). Early detection guides life-saving surveillance and precision prevention in high-risk families across the UAE.
يكشف هذا الاختبار القائم على تسلسل الجيل التالي عن الطفرات المسببة لمتلازمة التَّيَلُّس وسرطان المريء، مما يتيح مراقبة طبية مبكرة تنقذ الحياة وتوجيه استراتيجيات وقائية دقيقة للأسر المعرّضة للخطر.
| Parameter | Our Test | Closest Alternative |
|---|---|---|
| Precision | Full-gene NGS with CNV analysis (99.9% sensitivity) | Limited hotspot panel / Sanger sequencing only |
| Methodology | Illumina NovaSeq™ NGS + IGV visualization | Capillary electrophoresis or single-exon checks |
| Turnaround Time | 3–4 Weeks (21–28 calendar days) | 4–6 Weeks |
| UAE Insurance | Direct billing supported (WhatsApp verification) | Out-of-pocket or reimbursement only |
Physician Insight & Safety Protocol
“As a DHA-licensed specialist, I emphasize that a positive RHBDF2 result requires correlation with thorough dermatological and gastroenterological evaluation. This test is a starting point; your family history and clinical signs are equally important for life-saving surveillance.”
— Dr. Prabhakar Reddy, DHA License: 61713011
⚠️ Medication Notice:
Do not discontinue prescribed medication without consulting your doctor. Genetic test results must be interpreted alongside current treatment regimens.
Exclusion Criteria & Red Flags
This test is not appropriate for:
- Recipients of allogeneic bone marrow transplant within the last 6 months.
- Recent blood transfusion (within 2 weeks) – may interfere with germline DNA purity.
- Pregnancy – requires a separate genetic counselling protocol under UAE CDS Law 2026.
🚨 Seek emergency care if you experience: Sudden difficulty swallowing (dysphagia), unexplained weight loss >5% in 3 months, acute skin blistering or rapid progression of palmoplantar thickening.
Patient FAQ & Clinical Guidance
1. What does a positive RHBDF2 test mean for my future cancer risk?
A positive result confirms a pathogenic mutation that greatly increases lifetime risk of esophageal squamous cell carcinoma, demanding periodic endoscopic surveillance from age 25–30.
تؤكد النتيجة الإيجابية وجود طفرة ممرضة تزيد بشكل كبير من خطر الإصابة بسرطان المريء الحرشفي، مما يستوجب مراقبة دورية بالمنظار بدءاً من سن 25-30 عاماً.
2. Can I use a dried blood spot (FTA card) for the, and is it as accurate?
Yes, a single drop of blood on an FTA card yields DNA of sufficient quality for NGS, achieving equivalent diagnostic accuracy to venous blood when collected and stored correctly.
نعم، يمكن استخدام بقعة دم جافة على بطاقة FTA للحصول على حمض نووي بجودة كافية لتسلسل الجيل التالي، بدقة تشخيصية مماثلة للدم الوريدي عند الجمع والتخزين الصحيحين.
3. How long does it take to receive results and will a genetic counsellor explain them?
Results are delivered within 3–4 weeks through a secure portal, and a DHA-licensed genetic counsellor provides a complimentary telephonic explanation covering inheritance implications and personalized next steps.
تُسلم النتائج خلال 3-4 أسابيع عبر بوابة آمنة، ويقدم مستشار وراثي معتمد من هيئة الصحة شرحاً هاتفياً مجانياً يغطي دلالات الوراثة والخطوات الشخصية التالية.
This service complies with Federal Decree-Law No. 41 of 2024 (Art. 87), UAE CDS Law 2026 for minors, and UAE PDPL. All genetic data is handled under encrypted, ISO 9001:2015 certified protocols (Cert: INT/EGQ/2509DA/3139). DHA Licensed Facility No. 9834453.
2026 ICD-10-CM codes for clinical context: Z15.09 (Genetic susceptibility to esophageal cancer), Q82.8 (Tylosis palmaris et plantaris), C15.9 (Malignant neoplasm of esophagus, unspecified). LOINC: 86223-0.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians