Test Price
2,800 AED✅ Home Collection Available
RHBDF2 Gene Tylosis with Esophageal Cancer Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- ✓ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- ✓ Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation with a DHA-licensed genetic consultant.
- ✓ Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This NGS-based test screens the entire coding region of the RHBDF2 gene for pathogenic variants linked to Tylosis with Esophageal Cancer syndrome (Howel-Evans syndrome). Early detection guides life-saving surveillance and precision prevention in high-risk families across the UAE.
| Parameter | Our Test | Closest Alternative |
|---|---|---|
| Precision | Full-gene NGS with CNV analysis (99.9% sensitivity) | Limited hotspot panel / Sanger sequencing only |
| Methodology | Illumina NovaSeq™ NGS + IGV visualization | Capillary electrophoresis or single-exon checks |
| Turnaround Time | 3–4 Weeks (21–28 calendar days) | 4–6 Weeks |
| UAE Insurance | Direct billing supported (WhatsApp verification) | Out-of-pocket or reimbursement only |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics licensed by the DHA, I emphasize that a pathogenic RHBDF2 variant necessitates coordinated dermatological and gastroenterological surveillance. This molecular finding is a cornerstone for early intervention; your family pedigree and clinical presentation remain critical for life-saving management.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Guidance on Medication Continuity
Maintain Prescribed Therapy: Do not alter or stop any current medication without prior consultation with your treating physician. Genetic test results should be interpreted within the context of your ongoing treatment plan.
Exclusion Criteria & Red Flags
This test is not appropriate for:
- Recipients of allogeneic bone marrow transplant within the last 6 months.
- Recent blood transfusion (within 2 weeks) – may interfere with germline DNA purity.
- Pregnancy – requires a separate genetic counselling protocol under Federal Decree-Law No. 4 of 2016 on Medical Liability.
🚨 Seek emergency care if you experience: Sudden difficulty swallowing (dysphagia), unexplained weight loss >5% in 3 months, acute skin blistering or rapid progression of palmoplantar thickening.
Patient FAQ & Clinical Guidance
1. What does a positive RHBDF2 test mean for my future cancer risk?
A positive result confirms a pathogenic mutation that greatly increases lifetime risk of esophageal squamous cell carcinoma, demanding periodic endoscopic surveillance from age 25–30.
2. Can I use a dried blood spot (FTA card) for this test, and is it as accurate?
Yes, a single drop of blood on an FTA card yields DNA of sufficient quality for NGS, achieving equivalent diagnostic accuracy to venous blood when collected and stored correctly.
3. How long does it take to receive results and will a genetic counsellor explain them?
Results are delivered within 3–4 weeks through a secure portal, and a DHA-licensed genetic counsellor provides a complimentary telephonic explanation covering inheritance implications and personalized next steps.
UAE Regulatory & Data Privacy Adherence
All genetic data is processed under encrypted, ISO 9001:2015 certified protocols (Cert: INT/EGQ/2509DA/3139) and fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | RHBDF2 Gene Tylosis with Esophageal Cancer Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21–28 Calendar Days (3–4 Weeks) |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM – 11 PM) |
| Methodology Used | Illumina NovaSeq™ Next-Generation Sequencing (NGS) with CNV Analysis |
| ICD-10-CM Code | Z15.09, Q82.8, C15.9 |
| LOINC Code | 86223-0 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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