Test Price
2,800 AED✅ Home Collection Available
PMS2 Gene Genetic Test for Lynch Syndrome in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين PMS2 باستخدام التسلسل الجيني الشامل لمتلازمة لينش في الإمارات | 2800 درهم | إرشادات هيئة الصحة بدبي 2026
Executive Summary & UAE Compliance
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Next‑Generation Sequencing, validated by Sanger confirmation.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy (8 AM–11 PM).
- Clinical Guidance: Complimentary telehealth post‑test clinical interpretation by a certified genetic counsellor or oncologist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
جميع التحاليل معتمدة من مرفق صحي مرخص ومختبر حاصل على شهادة الأيزو 9001:2015، ويتم التعامل مع البيانات الوراثية وفق قانون حماية البيانات الشخصية الإماراتي لضمان أقصى درجات الخصوصية والسرية.
Clinical Overview & Comparative Performance
The PMS2 gene test identifies germline mutations responsible for Lynch syndrome (hereditary non‑polyposis colorectal cancer) and constitutional mismatch repair deficiency, guiding personalised cancer surveillance and prophylactic interventions. يتم إجراء التحليل على عينة دم كامل أو حمض نووي مستخلص أو بطاقة FTA، مع ضرورة استشارة وراثية مسبقة لتقييم التاريخ العائلي ورسم شجرة النسب.
| Feature | Our Test (PMS2 NGS) | Closest Alternative |
|---|---|---|
| Diagnostic Sensitivity | 99.9% (NGS + Sanger confirmation) | ~95% (Single‑gene Sanger) |
| Methodology | Full‑gene NGS, ACMG variant classification, MLPA for large rearrangements | Conventional Sanger sequencing, limited CNV detection |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Pre‑test Support | Complimentary genetic counselling session | Often not included |
Physician Insight & Safety Protocol
📋 Clinical Note from Dr. Prabhakar Reddy, DHA License 61713011
“A PMS2 result is a powerful risk marker, not a cancer diagnosis; it must always be correlated with family history and clinical findings. I reassure every patient that a variant of uncertain significance is far from a certainty, and we will navigate the implications together with empathy. Please remember that even a negative result does not eliminate the possibility of other hereditary syndromes, so ongoing screening remains vital.”
⛔ Medication & Safety Warning
Do not discontinue prescribed medication or cancer prevention therapies without consulting your supervising physician. Genetic information complements, but does not replace, standard clinical care.
🚨 Exclusion Criteria & Emergency Red Flags
- Patients unable to provide informed consent or where a legal guardian is not available (as per UAE CDS Law 2026 for minors).
- Individuals with active haematological malignancy that may interfere with DNA extraction from blood (alternative source required).
- Emergency Red Flags: sudden severe abdominal pain, unexplained rectal bleeding, or jaundice with weight loss – seek immediate emergency care.
Patient Questions & Bilingual Guidance
1. Who should consider PMS2 genetic testing?
Individuals with a personal or family history of colorectal or endometrial cancer before age 50 should undergo PMS2 analysis. Additional candidates include those with multiple Lynch‑spectrum cancers in the family, confirmed Lynch syndrome in a relative, or tumours showing microsatellite instability. Testing is also offered to asymptomatic adults seeking risk clarification, but it must be preceded by genetic counselling.
ينصح بإجراء التحليل للأشخاص الذين لديهم إصابة شخصية أو عائلية بسرطان القولون أو بطانة الرحم قبل سن الخمسين، أو عند وجود طفرات مؤكدة في العائلة. يجب إجراء استشارة وراثية مسبقة للتقييم الكامل.
2. How is the performed and what samples are accepted?
A simple blood draw, extracted DNA, or a dried blood spot on an FTA card is all that is required. Our phlebotomy team collects a venous blood sample in an EDTA tube following cold‑chain protocols, or you can provide pre‑extracted DNA. No fasting is necessary. The sample is sequenced with high‑coverage NGS, and pathogenic variants are confirmed by Sanger sequencing according to ACMG/AMP guidelines.
يتم سحب عينة دم وريدية أو استخدام الحمض النووي المستخلص مسبقاً، ولا يشترط الصيام. يتم تحليل الجين بتقنية التسلسل الجيني الشامل مع تأكيد الطفرات بطريقة سانجر لضمان الدقة.
3. What does a positive or negative result mean for my future health?
A positive result confirms hereditary Lynch syndrome, enabling life‑saving surveillance and risk‑reducing strategies, but it is not a cancer sentence. You will be offered a personalised surveillance plan (colonoscopy every 1–2 years, endometrial screening, etc.) and family cascade testing. A negative result significantly lowers your Lynch syndrome risk but does not eliminate sporadic cancer possibilities; routine screening remains essential. Variants of unknown significance are actively studied and reclassified over time.
النتيجة الإيجابية تؤكد متلازمة لينش وتستدعي خطة مراقبة دورية مكثفة لتقليل خطر السرطان. النتيجة السلبية تقلل الاحتمالية بشكل كبير لكن لا تلغي خطر السرطانات العادية. يتم متابعة الطفرات غير محددة الأهمية لإعادة تقييمها دورياً.
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