Test Price
2,800 AED✅ Home Collection Available
PALB2 Gene Breast Cancer Susceptibility Genetic Test in UAE | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- Diagnostic Sensitivity: 99.9% validated via ISO 9001:2015 (Certificate INT/EGQ/2509DA/3139) compliant NGS processing at DNA Labs UAE.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Medical Guidance: Telephonic post-test consultation with Consultant Medical Genetics, Ms. Lina Osama Zaki Quteineh (DHA ID: 9294403).
- Insurance Verification: Direct coverage confirmation via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The PALB2 NGS test sequences the entire coding region of the PALB2 gene to identify germline variants associated with significantly elevated breast and pancreatic cancer risk. This enables personalized prevention strategies and informed clinical surveillance for patients and their families. Processed entirely at DNA Labs UAE's CAP-accredited laboratory in Dubai Healthcare City, the test utilizes next-generation sequencing technology to deliver clinical-grade accuracy.
| Feature | PALB2 NGS (DNA Labs UAE) | Single-Site Alternative |
|---|---|---|
| Clinical Sensitivity | >99.9% for all coding variants | Limited to known founder mutations (~20% coverage) |
| Methodology | NGS with full exon & splice site coverage + Sanger confirmation | PCR-based targeted genotyping |
| Turnaround Time | 21–28 Days | 7–14 Days (less comprehensive) |
| Specimen Requirement | Peripheral whole blood (convenient home collection available) | Blood or buccal swab (clinic visit required) |
Physician Insight & Safety Protocols
“A PALB2 test is more than a genetic screening tool—it is a strategic health roadmap. An abnormal result must be carefully contextualized within your personal and family medical history. It empowers proactive surveillance but should never be a cause for panic. I strongly recommend pre- and post-test genetic counseling to ensure every decision is made with full clarity and confidence.”
— Ms. Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Safety Advisory
⚠️ Important: Do not stop or alter any prescribed medication including hormonal therapy, tamoxifen, or chemoprevention without consulting your treating physician. Always consult your healthcare provider before making changes to your medication regimen based on genetic test results.
Exclusion Criteria & Emergency Red Flags
- Individuals who cannot provide informed consent or are under 18 years of age (compliance with UAE Federal Law).
- Acute febrile illness or active bloodborne infection requiring isolation.
- Recent blood transfusion or bone marrow transplant within 3 months may affect DNA testing; consult your specialist.
- Emergency Red Flags: If you experience sudden severe breast lump, bloody nipple discharge, or unexplained weight loss, seek immediate medical attention and do not wait for test results.
Patient FAQ & Clinical Guidance
1. What does a positive PALB2 test mean for my breast cancer risk?
A positive PALB2 result indicates you carry a pathogenic variant that raises your lifetime breast cancer risk to 40–60%, requiring specialized breast MRI and mammograms from age 30. It is crucial to discuss cascade testing for eligible family members.
2. Why does the test take 21 to 28 days?
The 21–28 day turnaround ensures rigorous NGS sequencing with comprehensive bioinformatic analysis, variant classification per ACMG guidelines, and orthogonal Sanger validation—guaranteeing clinical‑grade accuracy you can trust.
3. Is genetic counseling mandatory before this test?
Yes, UAE regulations mandate pre-test genetic counseling to draw a detailed family pedigree and ensure informed consent before any hereditary cancer testing. DNA Labs UAE complies with Federal Decree-Law No. 4 of 2016 on Medical Liability. Our service includes a telephonic counseling session with our certified genetic counselor.
UAE Regulatory & Data Privacy Adherence
Your data is protected under UAE law.
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): We implement strict data governance frameworks to safeguard your genetic and medical information.
- Federal Law No. 2 of 2019: All health information is handled in accordance with the UAE's highest standards for the use of ICT in health fields.
- DHA Compliance: Our laboratory operates under DHA Facility License No. 1143, ensuring all tests meet Dubai Health Authority standards.
Clinical & Logistical Metadata
| Test Name | PALB2 Gene Breast Cancer Susceptibility (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21–28 Days (3–4 Weeks) |
| Sample Type / Matrix | Peripheral Whole Blood. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) with full exon & splice site coverage + Sanger confirmation |
| ICD-10-CM Code | Z15.01 |
| LOINC Code | 94083-9 |
| DHA Facility License & Laboratory Address | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE (DHA License No. 1143) |
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