Test Price
2,800 AED✅ Home Collection Available
MSH6 Gene Endometrial Cancer, Familial, MSH6-Related Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy and Temperature-Controlled Cold-Chain Home Collection across all Emirates (8 AM – 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a DHA-licensed genetic counsellor.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731 (English/Arabic).
Test Overview & Methodology
Comprehensive MSH6 Genetic Profiling via Next-Generation Sequencing
This advanced DNA test utilises Next-Generation Sequencing (NGS) to screen the entire coding region of the MSH6 gene for clinically actionable mutations associated with hereditary endometrial cancer and Lynch syndrome. It delivers a high-resolution risk assessment that empowers patients and oncologists to design personalised surveillance or prophylactic strategies.
Our Test vs. Conventional Single-Gene Analysis
| Feature | Our NGS-Based MSH6 Test | Conventional Single-Gene/PCR Test |
|---|---|---|
| Methodology | Next-Generation Sequencing (full gene, including deep intronic variants) | Sanger sequencing or targeted mutation panel (limited coverage) |
| Clinical Sensitivity | 99.9% (ISO-verified analytical sensitivity) | ~95% (may miss rare variants) |
| Turnaround Time | 3–4 Weeks (with cold-chain logistics) | 4–8 Weeks |
| Regulatory Compliance | DHA/MOHAP, UAE PDPL, Federal Law No. 2 of 2019 | Variable; often lacks local statutory alignment |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
“A genetic test result for MSH6 provides powerful predictive information, yet it must be interpreted within the full context of personal and family history. A positive finding indicates elevated risk, not a diagnosis of cancer. I recommend all patients review their results with a qualified genetic counsellor before making any lifestyle or medical decisions.”
Clinical Advisory & Medication Guidance
Medication Warning
Do not discontinue prescribed medication without consulting your doctor. This genetic test assesses hereditary cancer risk only and must not be used to modify ongoing cancer treatments or hormone therapies without explicit oncology supervision.
Patient Safety: Exclusion Criteria & ER Red Flags
Exclusion Criteria (Do not proceed without clinical clearance):
- Acute febrile illness or systemic infection at time of blood draw.
- Haemoglobin <8 g/dL or recent major blood transfusion (within 2 weeks).
- Inability to provide informed consent due to cognitive impairment.
- Individuals under 18 years unless accompanied by a legal guardian with court authorisation.
ER Red Flags – Seek immediate medical attention if:
- You experience severe anxiety or suicidal ideation after receiving genetic information.
- New onset of abnormal uterine bleeding, pelvic pain, or rapid weight loss (potential endometrial cancer signs).
- Any adverse reaction during home sample collection (e.g., syncope, allergic response to antiseptic).
This safety protocol is reviewed quarterly under ISO 9001:2015 and UAE PDPL data privacy standards.
Patient FAQ & Clinical Guidance
1. What is the MSH6 gene and how does it increase endometrial cancer risk?
Key Answer: The MSH6 gene encodes a DNA mismatch repair protein; inherited mutations significantly raise lifetime risk of endometrial and other Lynch syndrome cancers.
An MSH6 mutation disrupts the repair of DNA replication errors, leading to microsatellite instability and a cumulative risk of up to 40–60% for endometrial carcinoma by age 70. Carriers also face elevated risks for colorectal, ovarian, and gastric malignancies. This NGS test detects both point mutations and large rearrangements, enabling early surveillance colonoscopies, transvaginal ultrasound, and prophylactic options.
2. How is the test conducted and what is the turnaround time?
Key Answer: A simple blood draw or DNA sample is shipped under cold chain to our ISO-certified lab for NGS sequencing, delivering results in 3–4 weeks.
You may provide a whole blood sample, extracted DNA, or a dried blood spot on an FTA card. A DHA-licensed phlebotomist arrives at your home (8 AM–11 PM) in a temperature-controlled vehicle. After extraction and library preparation, sequencing is performed on an Illumina platform, followed by bioinformatic analysis aligned to the Genome Reference Consortium Human Build 38. Results are interpreted by a clinical molecular geneticist and shared via a secure portal.
3. Is the MSH6 genetic test covered by UAE insurance?
Key Answer: We verify your insurance coverage directly via WhatsApp (+971 54 548 8731); many major UAE plans cover genetic testing with medical necessity.
Under the current DHA coding guidelines, genetic counselling and MSH6 testing for familial cancer syndromes are reimbursed when a pre-authorisation request includes a documented family history and an oncology referral. Our billing team handles the entire pre-approval process and provides a clear explanation of any out-of-pocket costs before you proceed.
UAE Regulatory & Data Privacy Adherence
Legal Compliance & Data Protection
This service adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, and Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic and personal data are stored in Dubai Health Authority-compliant cloud infrastructure with end-to-end encryption.
Clinical & Logistical Metadata
| Test Name | MSH6 Gene Endometrial Cancer, Familial, MSH6-Related Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot (FTA Card). VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) – Full coding region, intronic boundaries, and large rearrangement detection. |
| ICD-10-CM Code | Z15.09 |
| LOINC Code | 21636-1 |
| DHA Facility License & Laboratory Address | License No: 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians