Test Price
2,800 AED✅ Home Collection Available
HOXB13 Gene (Prostate Cancer, Familial) Genetic Test | 2,800 AED | Accredited Genetics Laboratory in Dubai
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO-Accredited NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary Telephonic Post-Test Genetic Counseling & Result Interpretation with DHA-Licensed Specialists.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The HOXB13 Gene (Prostate Cancer, Familial) NGS test sequences the entire coding region of the HOXB13 gene to identify germline variants linked to hereditary prostate cancer susceptibility. This test is essential for individuals with a strong family history of prostate cancer, guiding personalized surveillance and risk-reduction strategies. The analysis is performed on the Illumina Next Generation Sequencing platform, providing comprehensive coverage of all exons and flanking intronic regions.
| Test Feature | Our NGS HOXB13 Test | Standard Sanger Sequencing |
|---|---|---|
| Precision | Full gene coverage plus deep intronic regions | Limited to selected exons |
| Methodology | Next Generation Sequencing (Illumina platform) | Chain-termination method |
| Turnaround Time | 3 to 4 Weeks | 6 to 8 Weeks |
| Price | 2,800 AED | Approximately 5,000 AED |
Physician Insight & Safety Protocols
"As a DHA-licensed Consultant Medical Geneticist, I confirm that a positive HOXB13 mutation indicates an elevated lifetime risk of prostate cancer but does not establish an active malignancy diagnosis. This result must be interpreted alongside the patient's documented family pedigree, digital rectal exam findings, PSA kinetics, and prostate MRI imaging. Clinical management decisions, including chemoprevention or intensified screening, should only be made after a multidisciplinary consultation involving a urologist and a clinical geneticist." — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice on Medical Management
Genetic Risk Interpretation Guidance:
A hereditary cancer susceptibility result does not replace ongoing oncological or urological follow-up. Patients must continue all prescribed surveillance protocols, including regular PSA testing and prostate exam schedules. The genetic report should never be used as a standalone basis for initiating or discontinuing any treatment or preventive therapy without a dedicated clinical genetics consultation.
Exclusion Criteria & Emergency Red Flags
- Active Uncontrolled Bleeding Disorder: Patients with hemophilia A/B or on high-dose anticoagulants without bridging clearance are not suitable for venipuncture.
- Severe Anemia or Hemodynamic Instability: If hemoglobin is below 7 g/dL or clinical instability is present, postpone the test until medically cleared.
- Acute Febrile Illness: Active infection may compromise DNA extraction quality; reschedule after full recovery and defervescence.
- Emergency Red Flags Post-Collection: Syncope, persistent bleeding beyond 10 minutes, or a rapidly expanding hematoma exceeding 5 cm at the venipuncture site requires immediate emergency room evaluation.
- Mandatory Pre-Test Genetic Counseling: Per UAE regulations, minors under 18 years require documented parental or guardian consent along with a pre-test genetic counseling session conducted by a DHA-licensed geneticist.
Patient FAQ & Clinical Guidance
1. What does a positive HOXB13 mutation mean for my health and my family?
A positive HOXB13 germline mutation indicates a significantly elevated lifetime risk of developing prostate cancer, approximately three to five times higher than the general population. This result does not diagnose active cancer but prompts intensified screening with PSA testing and prostate MRI beginning at age 40, along with cascade testing for first-degree blood relatives to identify at-risk individuals at an early, actionable stage.
2. How should I prepare for the HOXB13 genetic test and what sample is needed?
No fasting or special preparation is required. A standard blood draw of 3 to 5 mL collected in an EDTA tube provides sufficient DNA for full gene sequencing. A mandatory pre-test genetic counseling session is scheduled to document your three-generation family pedigree, ensuring the laboratory interprets any detected variants accurately within your specific clinical and familial context.
3. Is this genetic test covered by insurance and how does direct billing function?
Most major UAE health insurers cover hereditary cancer genetic testing when deemed medically necessary by a referring physician. Our team pre-verifies your coverage directly through WhatsApp at +971 54 548 8731 prior to scheduling the collection appointment. We accept direct billing from leading networks including Daman, AXA, Oman Insurance, and other providers under category reference 9834453, eliminating any upfront out-of-pocket expense for eligible policyholders.
4. Can family members also be tested for the same HOXB13 mutation?
Yes, cascade testing of at-risk relatives is strongly recommended when a pathogenic HOXB13 variant is identified in a proband. First-degree relatives, including parents, siblings, and children, carry a 50% risk of inheriting the same mutation. Our laboratory offers discounted familial variant testing for blood relatives, accompanied by dedicated genetic counseling for each tested family member to ensure informed consent and appropriate result interpretation.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with the United Arab Emirates federal legal framework governing genetic data and patient information. All genetic test results and associated personal data are processed and stored in accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), ensuring your genetic information is handled with the highest standards of confidentiality, consent management, and data minimization. Our laboratory information management system adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, which mandates secure electronic health record protocols and strict access controls for genetic data. Clinical safety and patient consent procedures for all genetic testing follow the standards established by Federal Decree-Law No. 4 of 2016 on Medical Liability, guaranteeing that every test is accompanied by documented informed consent, pre-test counseling, and transparent communication of results. DNA Labs UAE is fully licensed by the Dubai Health Authority under facility license number 1143.
Clinical & Logistical Metadata
| Test Name | HOXB13 Gene (Prostate Cancer, Familial) Genetic Test via NGS |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood (3 to 5 mL in EDTA tube) or FTA Card Blood Spot |
| Methodology Used | Next Generation Sequencing (Illumina Platform, Full Gene Coding Region plus Flanking Intronic Regions) |
| ICD-10-CM Code | Z15.03 – Genetic susceptibility to malignant neoplasm of prostate |
| LOINC Code | 81258-4 – HOXB13 gene targeted mutation analysis in Blood or Tissue by Molecular genetics method |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians