Test Price
1,200 AED✅ Home Collection Available
FOXO1 Break-Apart FISH Test for Alveolar Rhabdomyosarcoma Diagnosis in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval from any accredited hospital facility across the UAE.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by an Oncology Specialist.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
- Price: 1,200 AED — All-inclusive with no hidden facility fees.
- Turnaround Time: 7–8 working days from specimen receipt at our DHCC laboratory.
Test Overview & Methodology
The FOXO1 Break-Apart FISH test is the gold-standard molecular diagnostic for alveolar rhabdomyosarcoma, detecting chromosomal rearrangements of the FOXO1 gene with unparalleled precision. This test guides targeted therapy and prognosis, offering clarity when immunohistochemistry alone is inconclusive. The assay employs dual-color break-apart fluorescence in-situ hybridization probes targeting the FOXO1 locus at 13q14.11, enabling direct visualization of PAX3-FOXO1 and PAX7-FOXO1 fusions at the single-cell level within formalin-fixed, paraffin-embedded tumor tissue.
| Feature | Our FOXO1 FISH Test | Closest Alternative (IHC + PCR) |
|---|---|---|
| Diagnostic Precision | Break-apart probe, 99.9% sensitivity | ~85% with possible cross-reactivity |
| Methodology | Fluorescence In-Situ Hybridization (FISH) on tumor tissue | Immunohistochemistry ± RT-PCR |
| Turnaround Time | 7–8 working days | 10–14 days, often requires multiple steps |
Physician Insight & Safety Protocols
"As a clinician, I understand the anxiety a suspected sarcoma brings. This FOXO1 FISH test provides definitive molecular evidence to distinguish alveolar rhabdomyosarcoma from other small round cell tumors, directly shaping the intensity of therapy. Always interpret the result within the full clinical picture."
— Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA Registration ID: 61713011
Advisory Safety Information
Medication Warning
Do not discontinue any prescribed medication without consulting your treating physician. This FISH test is an adjunctive diagnostic tool and should not replace clinical judgment or established therapeutic protocols.
Exclusion Criteria & Safety Flags
- Uncontrolled bleeding disorder or therapeutic anticoagulation that cannot be safely paused.
- Active infection at the planned biopsy site.
- Inability to obtain a viable tumor tissue sample (e.g., inaccessible lesion without surgical intervention).
- ER Red Flags: Sudden severe pain at the tumor site, rapid enlargement, new neurological deficits, or signs of respiratory distress — seek emergency care immediately.
Patient FAQ & Clinical Guidance
1. What does a positive FOXO1 break-apart FISH result mean for my treatment plan?
A positive FOXO1 rearrangement confirms alveolar rhabdomyosarcoma, directly influencing the chemotherapy protocol and indicating the need for more intensive surveillance. It distinguishes this aggressive subtype from embryonal rhabdomyosarcoma, allowing oncologists to personalize your therapy and improve prognostic accuracy.
2. How accurate is this FISH test compared to standard biopsy with immunohistochemistry?
Our FISH analysis achieves 99.9% diagnostic sensitivity by directly visualizing the specific PAX3/7-FOXO1 fusion at the chromosomal level, eliminating false negatives common with immunohistochemistry and providing the most definitive molecular diagnosis currently available for this sarcoma subtype.
3. Is a hospital visit required for sample collection or can home phlebotomy be used?
Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety. The tumor biopsy must be performed by a qualified surgeon in a sterile operating environment. Once the tissue is obtained and processed into FFPE blocks, our Secure Medical Courier Solid Tissue Specimen Retrieval service coordinates transport to our DHCC laboratory under controlled conditions.
4. How long does it take to receive my FOXO1 FISH test results?
Results are typically available within 7 to 8 working days from the moment the FFPE tissue specimen arrives at our Dubai Healthcare City laboratory. A detailed molecular pathology report with interpretative commentary will be delivered electronically to you and your referring physician.
5. Will my health insurance cover the 1,200 AED cost of this test?
We offer direct billing verification with most major UAE insurance providers. Send a photo of your insurance card via WhatsApp to +971 54 548 8731, and our billing team will confirm your coverage and any co-pay obligations within one business day.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with the UAE's highest legal standards for clinical data protection and medical liability. All patient health information collected during the FOXO1 FISH testing process is governed by Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent follow the provisions of Federal Decree-Law No. 4 of 2016 on Medical Liability. Our DHA-licensed facility (License No. 1143) is located in Dubai Healthcare City and adheres to mandatory data protection impact assessments for all genetic and molecular diagnostic workflows.
Clinical & Logistical Metadata
| Test Name | FOXO1 Break-Apart FISH (Alveolar Rhabdomyosarcoma) |
| Price (AED) | 1,200 AED |
| Turnaround Time | 7–8 working days |
| Sample Type / Matrix | Formalin-Fixed Paraffin-Embedded (FFPE) tumor tissue block or biopsy slides |
| Methodology Used | Dual-Color Break-Apart Fluorescence In-Situ Hybridization (FISH) |
| ICD-10-CM Code | C49.9 |
| LOINC Code | 94470-2 |
| DHA Facility License & Laboratory Address | License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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