Test Price
2,800 AEDโ Home Collection Available
AKT1 Gene Cowden Syndrome Type 6 Genetic Test in Dubai | 2800 AED | NGS Analysis
Executive Summary & Core Metrics
Diagnostic Accuracy: >99.9% sensitivity via ISO 9001:2015 accredited next-generation sequencing.
Sample Logistics: VIP mobile phlebotomy & temperature-controlled cold-chain home collection available daily 8 AM โ 11 PM.
Clinical Oversight: Post-test genetic counseling and result interpretation provided by a DHA-licensed Consultant Medical Geneticist (DHA ID 9294403).
Insurance Verification: Direct billing inquiry via WhatsApp at +971 54 548 8731.
Price: 2,800 AED inclusive of comprehensive sequencing, variant analysis, and physician-validated report.
Test Overview & Methodology
The AKT1 gene Cowden syndrome type 6 assay employs next-generation sequencing (NGS) to identify pathogenic germline variants associated with hereditary cancer predisposition. This single-gene test provides full coverage of coding exons, splice sites, and flanking intronic regions with concurrent copy number variant (CNV) detection. A peripheral whole blood specimen collected on a DNA FTA card is the standard matrix. Results are delivered within 3โ4 weeks, enabling timely risk stratification and cascade family screening.
| Feature | DNA Labs UAE โ NGS Assay | Alternative Single-Gene Sanger |
|---|---|---|
| Analytical Sensitivity | >99.9% (full gene + CNV detection) | ~95% (coding exons only; deep intronic variants missed) |
| Turnaround Time | 3โ4 weeks | 4โ6 weeks |
| Price (AED) | 2,800 | ~3,500 (multiple primer sets often required) |
| Variant Interpretation | ACMG/AMP guidelines + ClinVar crossโreferencing | Manual Sanger trace review; limited to known hotspots |
| Post-Test Counseling | Mandatory physician consultation included | Rarely provided in standard lab packages |
Physician Insight & Safety Protocols
โA pathogenic AKT1 variant significantly elevates the lifetime risk of breast, thyroid, and endometrial malignancies. However, a negative result does not exclude other hereditary cancer syndromes. Clinical correlation, a comprehensive three-generation pedigree, and ongoing surveillance per national guidelines remain essential. Always consult your oncologist before altering any management plan.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA License 9294403
Advisory Notice
Do Not Interrupt Prescribed Care
This genetic test is a risk assessment tool and does not replace clinical diagnosis or established surveillance protocols. Continue all current medications and cancer screening regimens until directly instructed by your treating physician.
Exclusion Criteria & Safety Precautions
Contraindications and Required Precautions
- Not intended for prenatal diagnosis without prior formal genetic counseling and maternal-fetal medicine consultation.
- Minors under 18 years require legal guardian consent in accordance with UAE Federal Law No. 2 of 2019 on health information use.
- Active chemotherapy, radiation therapy, or recent blood product transfusion may compromise germline DNA yield. Contact our laboratory team for pre-collection assessment.
- Emergency Red Flags: Unexplained weight loss, palpable mass, persistent bleeding, or severe pain require immediate emergency evaluation. This test is not a screening tool for acute malignancy.
Patient FAQ & Clinical Guidance
1. What is the clinical purpose of the AKT1 Cowden syndrome type 6 genetic test?
Direct Answer: The test identifies inherited pathogenic AKT1 gene mutations responsible for Cowden syndrome type 6, enabling personalized cancer risk stratification, tailored surveillance protocols, and cascade screening of at-risk family members.
2. How should I prepare for the blood collection?
Direct Answer: No fasting is required. However, a mandatory pre-test genetic counseling session to document a detailed three-generation pedigree must be completed before sample collection. Our mobile phlebotomist will coordinate directly with you within the 8 AM โ 11 PM window.
3. What are the next steps if my result is positive?
Direct Answer: A positive result identifying a pathogenic or likely pathogenic variant activates a comprehensive surveillance plan tailored to your risk profile. Our Consultant Medical Geneticist will conduct a post-test telephonic consultation to review findings, coordinate with your referring physician, and initiate cascade testing for eligible relatives.
4. Does insurance cover the cost of this genetic test?
Direct Answer: Coverage varies by insurer. Our billing team can verify your direct billing eligibility via WhatsApp at +971 54 548 8731. The out-of-pocket price is 2,800 AED.
UAE Regulatory & Data Privacy Adherence
Compliance Framework
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): All genetic data is handled under strict privacy safeguards, with explicit patient consent for processing, storage, and authorized disclosure.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Electronic health records and test data transmission comply with national cybersecurity standards and patient data sovereignty requirements.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: All clinical testing and patient safety protocols adhere to this law governing medical professional responsibility and informed consent.
Clinical & Logistical Metadata
| Test Name | AKT1 Gene Sequencing โ Cowden Syndrome Type 6 |
| Price (AED) | 2,800 |
| Turnaround Time | 3โ4 weeks from sample receipt |
| Sample Type / Matrix | Peripheral whole blood (DNA FTA card); VIP mobile phlebotomy & temperature-controlled cold-chain home collection available daily 8 AM โ 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) with full coding region, splice site, and CNV analysis |
| ICD-10-CM Code | Q85.8 (Other phakomatoses, not elsewhere classified) |
| LOINC Code | 96504-5 (AKT1 gene mutation analysis) |
| DHA Facility License & Laboratory Address | DHA License 1143; Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians