Test Price
2,800 AEDโ Home Collection Available
VAPB Gene Amyotrophic Lateral Sclerosis Type 8 (ALS8) Genetic Test in UAE | 2,800 AED | DHA Licensed Laboratory
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity achieved via ISO 9001:2015 accredited laboratory processing (Cert: INT/EGQ/2509DA/3139) with full Sanger confirmation of all clinically significant variants.
- Premium Logistics: VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM for standard whole blood specimens.
- Clinical Guidance: Complimentary telephonic post-test clinical guidance on result interpretation provided by our genetics counselling team.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The VAPB gene NGS test detects pathogenic variants that cause autosomal dominant amyotrophic lateral sclerosis type 8, a rare familial motor neuron disorder. Our UAE-based molecular genetics laboratory deploys next-generation sequencing with comprehensive exon coverage and orthogonal Sanger confirmation, delivering unmatched precision in hereditary risk assessment for this debilitating condition.
| Feature | Our Test (DNA Labs UAE) | Closest Alternative |
|---|---|---|
| Precision | NGS with greater than 99% base coverage and Sanger validation | Limited targeted Sanger sequencing may miss rare variants |
| Methodology | Next-Generation Sequencing with full exon coverage and confirmatory Sanger | Conventional Sanger sequencing only |
| Turnaround Time | 14-21 Business Days (3-4 Weeks) | 6-8 Weeks |
| Price | 2,800 AED (all-inclusive) | Often exceeding 3,500 AED without genetic counselling |
Physician Insight & Safety Protocols
โGenetic testing for ALS type 8 requires careful interpretation within the context of a complete neurological history and examination. A pathogenic VAPB variant indicates elevated lifetime risk but does not alone confirm disease onset. I strongly recommend pre-test genetic counselling and post-test multidisciplinary discussion with a neurologist before any clinical decisions are made.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory Notice & Clinical Contraindications
Safety Considerations & Emergency Indicators
- Clinical Contraindications: This molecular assay is intended as a risk assessment and family planning tool; it does not replace a full diagnostic neurological workup. For individuals under 18 years, written informed consent from a legal guardian is mandatory as stipulated under Federal Decree-Law No. 4 of 2016 on Medical Liability. Do not alter or discontinue any prescribed medication without direct supervision by your treating physician.
- Emergency Indicators: Seek immediate emergency medical attention if you experience rapidly progressive muscle weakness, new-onset difficulty swallowing or speaking, unexplained shortness of breath, or loss of independent respiratory function.
Patient FAQ & Clinical Guidance
1. What is the VAPB gene test for ALS type 8?
This targeted genetic assay analyses the VAPB gene for known pathogenic and likely pathogenic variants associated with familial amyotrophic lateral sclerosis type 8, a rare autosomal dominant motor neuron disorder. The test utilises next-generation sequencing to interrogate all coding exons plus conserved splice sites, enabling early risk identification for clinically affected individuals and asymptomatic first-degree relatives.
2. Who should consider this genetic test?
Individuals with a documented family history of amyotrophic lateral sclerosis, particularly those with early-onset motor neuron disease or a known VAPB variant segregating within the family, are appropriate candidates. Asymptomatic first-degree relatives seeking clarity about their carrier status, and neurologists managing hereditary neurodegenerative presentations, also derive clinical utility from this analysis.
3. How is the test performed and what sample is required?
A standard peripheral whole blood draw collected in an EDTA tube is the preferred specimen. A licensed phlebotomist performs the collection during a scheduled home visit. The sample is transported under strict temperature-controlled cold-chain conditions to our ISO-certified molecular genetics laboratory. Results are typically available within 14 to 21 business days.
4. What does a positive result mean for my family?
A positive result confirms the presence of a pathogenic VAPB variant that follows autosomal dominant inheritance. This means each child of an affected individual has a 50% chance of inheriting the variant. We strongly recommend formal genetic counselling for the entire family to discuss reproductive options, presymptomatic testing protocols, and long-term neurological surveillance strategies.
5. Can a negative result rule out ALS completely?
No. A negative result for VAPB variants excludes only VAPB-associated ALS type 8. There are multiple other genes linked to familial and sporadic ALS, including SOD1, C9orf72, TARDBP, and FUS. A negative VAPB result does not rule out other genetic or non-genetic causes of motor neuron disease. Comprehensive neurological correlation remains essential.
UAE Regulatory & Data Privacy Adherence
Regulatory Framework: This genetic testing service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical laboratory procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring patient safety and informed consent standards. The laboratory holds DHA accreditation and follows MOHAP guidelines for genetic testing and counselling. Your genetic data is processed, stored, and transmitted under strict encryption and access-control protocols consistent with international best practices for genomic data privacy.
Clinical & Logistical Metadata
| Test Name | VAPB Gene Amyotrophic Lateral Sclerosis Type 8 (ALS8) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 14-21 Business Days (3-4 Weeks) |
| Sample Type / Matrix | Whole Blood (EDTA) or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | G12.21 |
| LOINC Code | 59027-5 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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