Test Price
2,800 AED✅ Home Collection Available
FUS Gene Amyotrophic Lateral Sclerosis Type 6 Genetic Test
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 certified processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic post-test clinical guidance by our consultant medical geneticist.
Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The FUS gene amyotrophic lateral sclerosis type 6 (ALS6) genetic test screens the entire coding region of the FUS gene using high-coverage next-generation sequencing (NGS) with multiplex ligation-dependent probe amplification (MLPA) validation for copy-number changes. This comprehensive approach identifies pathogenic single-nucleotide variants, insertions, deletions, and structural rearrangements linked to familial ALS. The test is performed on peripheral whole blood, extracted genomic DNA, or dried blood spot (FTA card) samples, delivering a precise molecular diagnosis within 3 to 4 weeks.
| Feature | Our NGS Test | Alternative (Sanger Sequencing of Selected Exons) |
|---|---|---|
| Precision | 99.9% analytical sensitivity, full gene coverage including deep intronic regions and MLPA for CNVs | Limited to targeted exons; may miss rare variants and copy-number changes |
| Methodology | NGS with MLPA validation for copy-number changes | Sanger sequencing of individual amplicons |
| Turnaround | 3–4 Weeks | 4–6 Weeks |
Physician Insight & Safety Protocols
"Interpreting genetic results requires integrating molecular findings with a comprehensive neurological examination. A pathogenic variant in the FUS gene confirms a genetic etiology for ALS type 6 and warrants genetic counseling for the patient and at-risk relatives. A negative result does not exclude all hereditary forms of motor neuron disease, and further testing may be indicated based on clinical phenotype."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics / DHA Registration ID: 9294403Medication & Safety Advisory
Medication Warning
Do not discontinue prescribed medication without consulting your neurologist. No lifestyle or supplement changes should be initiated based solely on genetic test results.
Exclusion Criteria
- Inability to provide informed consent unless a legal guardian is present.
- Recent blood transfusion within the past two weeks may require an alternate sample type.
- Active chemotherapy may compromise extracted DNA quality.
Emergency Red Flags
- Rapidly progressive muscle weakness, difficulty breathing, or choking sensation – seek immediate emergency care.
- Severe mood disturbances or suicidal ideation upon learning results – call 998 for immediate psychological assistance.
- Genetic results are not for acute diagnostic emergencies; always correlate with clinical assessment.
Patient FAQ & Clinical Guidance
1. What does a positive FUS gene mutation mean for my ALS type 6 diagnosis?
A positive FUS gene mutation confirms the genetic cause of amyotrophic lateral sclerosis type 6, requiring immediate genetic counseling and neurological monitoring. Early identification allows for proactive management and family planning discussions.
2. How is the sample collected and is home phlebotomy available?
A certified phlebotomist visits your home between 8 AM and 11 PM to collect a venous blood sample or a finger-prick dried blood spot on an FTA card. All samples are transported using temperature-controlled cold-chain logistics to ensure integrity.
3. Will insurance cover the 2800 AED cost for this genetic test?
Many UAE insurance plans cover genetic testing for ALS when medically indicated. Direct billing verification is available via WhatsApp at +971 54 548 8731.
UAE Regulatory & Data Privacy Adherence
Compliance Framework
- Data privacy protection under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) with encrypted storage and secure transmission.
- Health data integrity and confidentiality compliant with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical test safety and patient consent in adherence with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- ISO 9001:2015 Certified Laboratory (Cert: INT/EGQ/2509DA/3139) ensuring process excellence.
Clinical & Logistical Metadata
| Test Name | FUS Gene Amyotrophic Lateral Sclerosis Type 6 (ALS6) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) with MLPA for Copy Number Variation Detection |
| ICD-10-CM Code | G12.21 |
| LOINC Code | 83547-3 |
| DHA Facility License & Address | DHA License 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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