Test Price
2,800 AED✅ Home Collection Available
ATXN1 Gene Spinocerebellar Ataxia Type 1 (SCA1) Autosomal Dominant Genetic Test in UAE | 2800 AED | DHA Licensed Lab 1143
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO‑accredited Next‑Generation Sequencing with specialised CAG‑repeat analysis.
- Premium Logistics: Paid Hospital‑Grade Home Collection with ISO‑certified cold‑chain transport and VIP Mobile Phlebotomy (8 AM‑11 PM).
- Clinical Guidance: Telephonic post‑test clinical correlation and result interpretation by a DHA‑licensed Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- Investment: 2,800 AED (All‑inclusive of genetic counselling and technical analysis).
Test Overview & Methodology
The ATXN1 Genetic Test utilises Next‑Generation Sequencing (NGS) technology to identify pathogenic CAG trinucleotide repeat expansions within the ATXN1 gene. This analysis confirms a diagnosis of Autosomal Dominant Spinocerebellar Ataxia Type 1 (SCA1), facilitating precise neurological management, prognostic evaluation, and predictive assessment for asymptomatic first‑degree relatives. The integration of orthogonal Sanger sequencing ensures 99.9% diagnostic sensitivity for repeat sizing.
| Feature | DNA Labs UAE | Standard Alternative |
|---|---|---|
| Methodology | NGS with validated CAG‑repeat bioinformatics + Sanger confirmation | Conventional PCR with fragment analysis only |
| Turnaround Time | 3–4 Weeks (pre‑ and post‑test counselling integrated) | 4–6 Weeks, without genetic counselling |
| UAE Compliance | DHA License 1143, PDPL 2021, ISO 9001:2015 | May lack UAE‑specific legal audit trail |
Physician Insight & Safety Protocols
“SCA1 is a neurodegenerative condition with variable penetrance, influenced by the size of the CAG repeat expansion. A positive genetic test result provides a definitive diagnosis but does not solely dictate the clinical trajectory. Multidisciplinary care, involving neurology, genetics, and rehabilitation medicine, is essential. Predictive testing for asymptomatic first‑degree relatives requires structured pre‑ and post‑test genetic counselling, ethical committee approval, and full compliance with UAE PDPL (Federal Decree-Law No. 45 of 2021). I strongly advocate for comprehensive pedigree analysis and psychosocial support prior to any presymptomatic testing.”
– Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Safety Exclusion & Clinical Contraindications
- Exclusion Criteria: Unstable psychiatric conditions, inability to provide informed consent (unless legal guardian present), acute infectious illness requiring hospitalisation, pregnancy with high‑risk complications (requires separate obstetric assessment).
- Pre-Test Clinical Advisory: Patients undergoing anticoagulant therapy must inform the phlebotomist. Bruising or bleeding risk should be assessed prior to peripheral blood draw. Discontinue only under physician advice.
Patient FAQ & Clinical Guidance
1. What is Spinocerebellar Ataxia Type 1 (SCA1)?
A: SCA1 is a progressive, autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the ATXN1 gene. It primarily affects the cerebellum, leading to coordination difficulties, speech impairment, and motor dysfunction. Onset typically occurs in adulthood, with earlier expansions correlating to more severe disease.
2. What does the ATXN1 genetic test involve?
A: The test requires a single peripheral whole blood sample (5 mL) collected via standard phlebotomy. DNA is extracted and analyzed using Next‑Generation Sequencing (NGS) specifically configured to measure the exact number of CAG repeats in the ATXN1 gene. Results are reported with a clinical interpretation from a Consultant Medical Geneticist.
3. Why is genetic counselling mandatory before this test?
A: UAE healthcare regulations (Federal Decree-Law No. 4 of 2016 on Medical Liability and DHA guidelines) mandate a pre‑test genetic counselling session for all predictive and diagnostic genetic testing. Counselling includes informed consent, pedigree analysis, discussion of penetrance and potential psychological impact, and clarification of Familial implications. This ensures autonomous decision‑making and compliance with UAE data protection laws (PDPL 45/2021).
4. Can predictive testing be performed on minors in the UAE?
A: Predictive testing for minors is strictly regulated under Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. It is only permitted if direct medical surveillance or therapeutic interventions are available that can alter disease progression. Testing requires mandatory parental consent, a multidisciplinary ethics committee review, and the documented best interests of the child.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Clinical Governance Framework
DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access‑restricted, and processed solely for diagnostic and therapeutic purposes. Clinical consent follows Federal Decree-Law No. 4 of 2016 on Medical Liability. Our operations are governed by DHA Facility License 1143, ensuring full alignment with Dubai Healthcare City quality and legal standards.
Clinical & Logistical Metadata
| Test Name | ATXN1 Gene Spinocerebellar Ataxia Type 1 (SCA1) Autosomal Dominant Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (5 mL) |
| Methodology Used | Next‑Generation Sequencing (NGS) with CAG‑Repeat Analysis |
| ICD-10-CM Code | G11.0 |
| LOINC Code | 94880-2 |
| DHA Facility License & Laboratory Address | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | License: 1143 |
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