Test Price
2,800 AED✅ Home Collection Available
ZNF674 Gene Mental Retardation, X-Linked Type 92 Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO-accredited next-generation sequencing (NGS). Every variant is confirmed through orthogonal validation and aligned with international clinical genomics standards.
Premium Logistics: VIP Mobile Phlebotomy with temperature-controlled cold-chain home collection performed by DHA-licensed professionals. Available daily from 8 AM to 11 PM with specimen stabilization within 45 minutes of collection.
Clinical Guidance: Post-test telehealth consultation with a consultant medical genetics specialist for result interpretation, risk stratification, recurrence risk counselling, and family planning support.
Insurance Direct Billing Verification: WhatsApp +971 54 548 8731 for real-time pre-approval and coverage confirmation.
Test Overview & Methodology
This targeted genetic test sequences the entire coding region and conserved splice sites of the ZNF674 gene to detect single-nucleotide variants, small insertions and deletions, and copy number variants causative of X-linked intellectual disability type 92. The assay employs a clinically validated targeted NGS panel with minimum 100x coverage across all exons, followed by Sanger confirmation of all pathogenic and likely pathogenic calls.
Variant interpretation follows ACMG/AMP guidelines and is correlated with the patient's developmental history, neurological examination findings, and three-generation family pedigree. Results are delivered with a comprehensive clinical report that includes variant significance, inheritance pattern analysis, and evidence-based management recommendations.
| Feature | DNA Labs UAE Targeted NGS Assay | Alternative Research-Grade WES/WGS |
|---|---|---|
| Precision | Coverage ≥100× across all ZNF674 exons; analytical sensitivity 99.9% for SNVs and indels; all pathogenic calls confirmed by Sanger sequencing. | Variable exon capture efficiency; variant call confidence dependent on whole genome depth; no dedicated gene-level validation. |
| Method | Targeted NGS panel with orthogonal confirmation; designed specifically for X-linked intellectual disability genes. | Whole exome or whole genome sequencing without targeted gene enrichment; may miss low-coverage regions. |
| Turnaround Time | 3–4 weeks from sample receipt; expedited reporting available upon request. | 6–12 weeks typical; often lacks dedicated clinical interpretation and family counselling integration. |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics specializing in neurodevelopmental disorders, I confirm that targeted sequencing of ZNF674 provides a definitive molecular diagnosis for X-linked intellectual disability type 92. However, every genetic result must be interpreted within the complete clinical context, including developmental history, neurological examination, and a three-generation family pedigree. Do not base therapeutic or family planning decisions solely on this molecular finding without comprehensive multidisciplinary consultation involving clinical genetics, neurology, and developmental paediatrics.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory & Safety Precautions
Important Safety Information
Do not discontinue prescribed medication without consulting your doctor.
Genetic test results may cause psychological distress or anxiety. Patients and families are advised to seek genetic counselling before and after testing. If you experience new-onset seizures, loss of consciousness, severe behavioural regression, or signs of depression following result disclosure, seek immediate medical attention. For urgent psychiatric or neurological crises, call UAE National Ambulance 998 and present your genetic report.
Exclusion Criteria for Sample Collection
Do Not Proceed with Sample Collection If:
- Patient is currently febrile or has an active systemic infection that may compromise whole blood DNA integrity.
- Recent blood transfusion within the past two weeks or active haematologic malignancy that may dilute or mask germline variants.
- Inability to provide valid DHA-compliant informed consent in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability and Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
Patient FAQ & Clinical Guidance
1. What does a positive ZNF674 test result mean for my child's future development?
A positive result confirms the diagnosis of X-linked intellectual disability type 92, enabling early intervention planning, tailored neuro-rehabilitation programmes, and precise recurrence risk estimates for future pregnancies. The consultant medical geneticist will coordinate a multidisciplinary care plan involving developmental paediatrics, speech and occupational therapy, and educational support within days of result release.
2. Why is genetic counselling mandatory before sample collection?
Pre-test genetic counselling is a mandatory safety measure to construct a three-generation pedigree, clarify implications for at-risk relatives, discuss potential psychological impacts, and secure truly informed consent compliant with UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. This ensures full psychosocial support is in place before results are available.
3. How is home sample collection performed and is it safe for children?
A DHA-licensed paediatric phlebotomist visits your home with an ISO-certified cold-chain collection kit. A gentle venous draw or capillary finger-prick using an FTA card is performed to minimise discomfort. The sample is immediately stabilised, tracked via GPS, and transported to the laboratory within 45 minutes. This procedure is completely safe for children of all ages provided the exclusion criteria are not present.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Security: All genetic data is processed and stored in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient information is encrypted, access-controlled, and never shared with third parties without explicit written consent.
Clinical Safety & Consent: Sample collection and testing procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring informed consent, patient safety, and accountability throughout the diagnostic pathway.
Accreditations: ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and fully licensed by the Dubai Health Authority (DHA).
Clinical & Logistical Metadata
| Test Name | ZNF674 Gene Mental Retardation, X-Linked Type 92 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks from sample receipt |
| Sample Type / Matrix | Whole Blood (peripheral venous or capillary FTA card). VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Targeted Next-Generation Sequencing (NGS) with Sanger confirmation of all pathogenic/likely pathogenic variants |
| ICD-10-CM Code | F79, Q99.8, Z14.8 |
| LOINC Code | 86246-4 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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