Test Price
2,800 AEDโ Home Collection Available
CUL7 Gene (Three M Syndrome Type 1) Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Next-Generation Sequencing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection โ Available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test genetic counseling and result interpretation by a Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- DHA Licensed: Facility License #1143, Dubai Healthcare City.
Test Overview & Methodology
The CUL7 Gene NGS test is a comprehensive next-generation sequencing analysis that identifies pathogenic variants in the entire coding region of the CUL7 gene, confirming the diagnosis of Three M syndrome type 1 in individuals presenting with characteristic dysmorphic features, proportionate short stature, and skeletal abnormalities. This ISO-accredited, DHA-licensed UAE-based service delivers definitive genetic results within 3โ4 weeks, supporting clinical management, family planning, and carrier detection.
| Feature | Our Test (NGS) | Closest Alternative (Sanger) |
|---|---|---|
| Precision | Full-gene coverage, high analytical sensitivity (>99.9%) | Limited exon-by-exon coverage, lower variant detection |
| Methodology | Next-Generation Sequencing (NGS) โ Whole coding region + splice sites | Sanger Sequencing โ Targeted exons only |
| Turnaround | 3โ4 Weeks | 6โ8 Weeks |
| Diagnostic Yield | Superior for rare, novel, and mosaic variants | Standard for known familial mutations only |
| Sample Requirement | Whole blood (EDTA), extracted DNA, or FTA card | Whole blood (EDTA) required |
Physician Insight & Safety Protocols
โGenetic testing for CUL7 provides critical diagnostic clarity for Three M syndrome type 1. However, results must always be interpreted within the full clinical context, including a detailed dysmorphology assessment, growth parameters, and family history. A negative result does not rule out atypical presentations or variants outside the tested region. Post-test genetic counseling is essential for informed medical decision-making and should never be replaced by a laboratory report alone.โ
โ Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory
Important:
Do not discontinue prescribed medication without consulting your doctor. Genetic test results do not replace ongoing medical management or existing treatment plans.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria
- Not indicated for asymptomatic individuals without prior genetic counseling.
- Not a substitute for a complete dysmorphology evaluation by a clinical geneticist.
- Carrier testing requires confirmed familial mutation and pre-test counseling.
Emergency Red Flags
- Seek immediate emergency care if the patient develops acute respiratory distress, feeding intolerance with recurrent vomiting, or signs of cardiac failure (cyanosis, poor perfusion, unexplained tachycardia).
Patient FAQ & Clinical Guidance
1. What is the CUL7 Gene NGS Test and why is it performed?
The CUL7 NGS test is a high-precision genetic analysis that sequences the entire coding region and splice junctions of the CUL7 gene to confirm a diagnosis of Three M syndrome type 1 in individuals with proportionate short stature, distinctive facial features, and skeletal changes. It is also used for carrier testing in families with a known CUL7 pathogenic variant and for prenatal diagnosis when indicated.
2. How is the test performed and what sample is required?
Testing requires a single blood draw (whole blood in an EDTA tube), a pre-extracted DNA sample, or one drop of blood on an FTA card. Our DHA-licensed phlebotomists perform VIP mobile phlebotomy at your home with temperature-controlled cold-chain logistics, ensuring sample integrity from collection to laboratory processing. Home collection is available daily from 8 AM to 11 PM.
3. What do the results mean and how long does it take?
Results are reported within 3โ4 weeks from sample receipt. A positive report identifies a pathogenic or likely pathogenic CUL7 variant that confirms the clinical diagnosis. A negative result reduces suspicion but does not exclude atypical presentations, deep intronic variants, or mosaic mutations below the detection threshold. Post-test genetic counseling and clinical correlation are mandatory before any medical decisions.
UAE Regulatory & Data Privacy Adherence
This diagnostic service operates in full compliance with UAE federal data protection and healthcare information regulations:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) โ governs the collection, processing, and storage of your genetic and personal data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields โ ensures secure handling of electronic health records and telemedicine interactions.
- Federal Decree-Law No. 4 of 2016 on Medical Liability โ establishes the legal framework for clinical practice, patient consent, and safety in diagnostic testing.
Your genetic data is encrypted, access-restricted, and never shared with third parties without your explicit written consent.
Clinical & Logistical Metadata
| Test Name | CUL7 Gene (Three M Syndrome Type 1) Genetic Test โ Next-Generation Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full coding region and splice sites |
| ICD-10-CM Code | Q87.1 โ Congenital malformation syndromes predominantly associated with short stature |
| LOINC Code | 94219-1 โ CUL7 gene mutation analysis |
| DHA Facility License & Address | License #1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians