Test Price
2,800 AED✅ Home Collection Available
POLG Gene Alpers Syndrome Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Our POLG Gene Alpers Syndrome Genetic Test delivers 99.9% diagnostic sensitivity using ISO‑accredited NGS technology, with results interpreted by DHA‑licensed clinical geneticists. Premium logistics include VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (8 AM – 11 PM) for standard peripheral blood specimens. Telephonic post‑test clinical guidance is provided by a DHA‑certified genetic counsellor. Direct billing verification available via WhatsApp at +971 54 548 8731. Fully compliant with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of ICT in Health Fields. Clinical safety protocols adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Test Overview & Methodology
The POLG gene test utilizes Next‑Generation Sequencing (NGS) to screen for pathogenic variants associated with Alpers syndrome, a severe mitochondrial DNA depletion disorder primarily affecting the brain and liver. Our comprehensive approach ensures high sensitivity across the entire coding region and exon‑intron boundaries.
| Parameter | Our Test (NGS Full Gene) | Closest Alternative (Sanger Sequencing Single Exon) |
|---|---|---|
| Precision | 99.9% sensitivity, covers entire coding region + exon‑intron boundaries | ~95% for targeted hotspot only |
| Methodology | Illumina NGS with bioinformatics pipeline validated by ISO 9001 | Capillary electrophoresis; limited variant detection |
| Turnaround Time | 3–4 weeks | 4–6 weeks |
| Genetic Counseling | Pre‑ and post‑test DHA‑certified counselling included | Often additional cost or unavailable |
Physician Insight & Safety Protocols
A Message from Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403):
This genetic test provides precise molecular evidence for Alpers syndrome, yet it must always be interpreted within the complete clinical context. I strongly advise patients and families to discuss any neurological signs with their healthcare provider promptly. A negative result does not entirely rule out mitochondrial disease, so ongoing clinical surveillance remains crucial.
Medication and Safety Advisory
Do not discontinue any prescribed medication without consulting your doctor. Abrupt cessation may worsen neurological status. Always inform your physician about all medications and supplements before undergoing genetic testing.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Home phlebotomy is not suitable for patients with acute haemodynamic instability, severe anaemia (Hb < 7 g/dL), or an active bleeding disorder.
- Red Flags – Seek Immediate Medical Attention: New‑onset seizures, severe jaundice, sudden loss of consciousness, or rapid developmental regression. These symptoms may indicate an acute crisis unrelated to the blood draw.
Patient FAQ & Clinical Guidance
1. What exactly does the POLG Alpers syndrome DNA test detect?
It analyzes the POLG gene using Next‑Generation Sequencing to identify pathogenic variants causing Alpers syndrome. This enables accurate diagnosis and early intervention.
2. How should I prepare for the blood collection?
No special preparation is required; however, a pre‑genetic counselling session is mandatory to discuss family history and obtain informed consent.
3. How will I receive and understand my results?
Results are delivered in 3–4 weeks via a secure patient portal and a telephonic consultation with a DHA‑certified geneticist.
UAE Regulatory & Data Privacy Adherence
All clinical data is processed in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient safety and consent are governed by Federal Decree‑Law No. 4 of 2016 on Medical Liability. DNA Labs UAE is licensed by the Dubai Health Authority (License No. 1143) and operates under ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | POLG Gene Alpers Syndrome Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole Blood (Peripheral) – VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily 8 AM–11 PM |
| Methodology Used | Next‑Generation Sequencing (NGS) – Illumina platform, ISO 9001 validated |
| ICD-10-CM Code | G31.81 |
| LOINC Code | 81247-9 |
| DHA Facility License & Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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