Test Price
2,800 AED✅ Home Collection Available
XK Gene (McLeod Syndrome with or without Chronic Granulomatous Disease) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited NGS Processing for XK gene variants.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM – 11 PM.
Clinical Guidance: Telephonic Post-Test Consultation with a Consultant Medical Geneticist for result interpretation.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced next‑generation sequencing (NGS) test analyzes the entire XK gene for pathogenic variants associated with McLeod syndrome, a rare neuroacanthocytosis disorder, with or without co‑occurring chronic granulomatous disease (CGD). The assay provides full gene coverage including intronic regions and deletion/duplication analysis, enabling precise clinical decision‑making.
| Feature | Our XK Gene NGS Test (DNA Labs UAE) | Standard Regional Panel |
|---|---|---|
| Precision | ≥99.9% Sensitivity & Specificity for XK variants | Variable, often <95% |
| Methodology | Full XK Gene Sequencing via NGS with deletion/duplication analysis | Limited targeted genotyping |
| Turnaround Time | 3–4 Weeks (Expedited available) | 6–8 Weeks |
| Interpretation | Clinical correlation with neurologist & geneticist, DHA‑compliant report | VCF‑only output |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics licensed by the DHA, I emphasize that genetic test results must always be integrated with the full clinical picture — including neurological examination, complete blood count with smear, and immunological workup. A single gene assay does not replace multidisciplinary evaluation. Any medication adjustments should be discussed with your treating specialist.”
Advisory: Medication & Management Precautions
⚠️ Important Medication Notice
Do not discontinue or alter any prescribed medications — including immunosuppressants, prophylactic antibiotics, or anticonvulsants — without explicit direction from your treating physician. Sudden changes may trigger complications in individuals with underlying neurological or immunological conditions.
Safety Exclusion Criteria & Red Flags
- Active hemolytic crisis requiring urgent transfusion support.
- Uncontrolled infection or severe immunosuppression (e.g., absolute neutrophil count < 500).
- Pregnancy or lactation — requires specialist risk-benefit assessment before proceeding.
- Sudden onset of dysphagia, respiratory difficulty, or rapid neurological decline — seek emergency care immediately.
Patient FAQ & Clinical Guidance
1. What does this genetic test detect, and who should consider it?
This NGS test identifies pathogenic variants in the XK gene responsible for McLeod syndrome, a progressive neuroacanthocytosis disorder, and may also reveal mutations linked to chronic granulomatous disease. It is indicated for individuals with unexplained chorea, acanthocytosis on blood smear, elevated creatine kinase, or recurrent infections suggestive of CGD.
2. How is the sample collected, and is any preparation required?
A peripheral blood sample (3–5 mL in EDTA tube) is sufficient. No fasting or special preparation is needed. Our VIP Mobile Phlebotomy service can collect the sample at your home or office between 8 AM and 11 PM, using ISO-certified cold-chain logistics.
3. How will I receive my results, and what follow-up support is available?
Results are delivered via a secure DHA-compliant portal within 3–4 weeks. You will receive a telephonic post-test consultation with our Consultant Medical Geneticist to explain the findings, discuss implications for family members, and coordinate referrals to a neurologist or immunologist if necessary.
UAE Regulatory & Data Privacy Adherence
Data Privacy: All genetic data is processed in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Laboratory Certification: DNA Labs UAE is ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139) and operates under DHA Facility License No. 1143.
Clinical & Logistical Metadata
| Test Name | XK Gene (McLeod Syndrome with or without Chronic Granulomatous Disease) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks (expedited options available) |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA), 3–5 mL |
| Methodology Used | Next‑Generation Sequencing (NGS) – full gene sequencing with deletion/duplication analysis |
| ICD-10-CM Code | G24.8 (Other forms of dystonia), E75.6 (Other lipid storage disorders) |
| LOINC Code | 21649-0 (Genetic analysis, whole gene sequencing) |
| DHA Facility License & Laboratory Address | DHA License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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