Test Price
2,800 AED✅ Home Collection Available
TREX1 Gene Aicardi-Goutières Syndrome Type 1 Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This genetic test analyses the entire coding region of the TREX1 gene to detect pathogenic variants linked to Aicardi-Goutières syndrome type 1, a severe early-onset encephalopathy. This assay delivers a definitive molecular diagnosis, guiding clinical management, genetic counselling, and family planning.
| Feature | Our TREX1 NGS Test | Closest Alternative (Conventional Sanger Sequencing) |
|---|---|---|
| Methodology | NGS (Next Generation Sequencing) – full gene coverage, including deep intronic borders | Sanger sequencing of selected exons only |
| Detection Rate | >99.9% for single nucleotide variants, small indels, and copy number changes | ~90% – cannot detect large deletions/duplications |
| Turnaround Time | 3 to 4 Weeks | 4 to 6 Weeks (if multiple amplicons needed) |
| Price (AED) | 2,800 | 2,400–3,200 (depending on fragments) |
Physician Insight & Safety Protocols
From Ms. Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403): “Diagnosing a rare inherited encephalopathy such as Aicardi-Goutières syndrome requires precision and compassion. This NGS-based TREX1 gene analysis provides definitive molecular evidence to confirm the clinical suspicion, enabling early intervention and accurate recurrence risk counselling for affected families. I emphasize that every result must be interpreted within the full clinical context and discussed with a certified genetic counsellor before any management decisions are made.”
Pre-Test Advisory
Important Clinical Precautions
- Medication Continuity: Do not discontinue any prescribed therapy without consulting your treating physician. This test is elective and does not replace ongoing medical care.
- Mandatory Pre-Test Counselling: A formal genetic counselling session is required to document a three‑generation pedigree and capture family history of Aicardi-Goutières syndrome.
- Informed Consent: Written informed consent must be obtained prior to sample collection, acknowledging the scope and limitations of NGS analysis.
Exclusion Criteria & Emergency Indicators
Patient Suitability & Urgent Care
- Exclusion Criteria: Individuals unable to provide informed consent or those with samples failing pre-analytical quality checks (e.g., clotted whole blood, insufficient DNA yield) are not eligible for this test.
- Emergency Red Flags: Acute neurological deterioration, new-onset seizures, or severe developmental regression requires immediate emergency medical attention. This diagnostic test is not a substitute for urgent clinical care.
Patient FAQ & Clinical Guidance
1. What is the TREX1 gene and why is it tested?
The TREX1 NGS test detects pathogenic mutations in the TREX1 gene responsible for Aicardi-Goutières syndrome type 1 with >99.9% accuracy. It examines all coding exons and flanking splice regions, identifying single nucleotide variants, small insertions/deletions, and exon-level copy number changes. This comprehensive approach confirms or rules out a molecular diagnosis and enables targeted management and family planning decisions.
2. How long does it take to receive results?
Standard turnaround time for the TREX1 NGS test is 3 to 4 weeks from the day the sample arrives at our laboratory. This includes DNA extraction, library preparation, sequencing, bioinformatic analysis, and a dual‑reviewed clinical report. Expedited processing may be available upon medical request at no additional cost.
3. Is this test covered by UAE health insurance?
Many UAE insurers cover the TREX1 NGS test when pre‑authorization is obtained through a neurologist or clinical geneticist. Our team validates your coverage directly via WhatsApp at +971 54 548 8731 before the blood draw. We also provide a detailed medical necessity letter to support the claim.
UAE Regulatory & Data Privacy Adherence
Federal Compliance Framework
This test is performed in strict adherence to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic counselling sessions comply with DHA and MOHAP standards.
ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139) | DNA Labs UAE
Clinical & Logistical Metadata
| Test Name | TREX1 Gene Aicardi-Goutières Syndrome Type 1 Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) or Extracted DNA |
| Methodology Used | Next Generation Sequencing (NGS) |
| ICD-10-CM Code | G04.81 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DHA License No: 1143 |
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