Test Price
2,800 AED✅ Home Collection Available
TNFRSF11A Gene Sequencing for Autosomal Recessive Osteopetrosis Type 7 (NGS) in UAE | 2800 AED | 2026 DHA Guidelines
تحليل تسلسل جين TNFRSF11A لمرض تصلب العظام الوراثي المتنحي من النوع السابع (NGS) في الإمارات | 2800 درهم | إرشادات هيئة الصحة بدبي 2026
🔬 99.9% Diagnostic Sensitivity
ISO 9001:2015 accredited processing (Cert: INT/EGQ/2509DA/3139). LC–MS/MS & NGS final confirmation.
الملخص التنفيذي
نقدم تحليل جين TNFRSF11A بأحدث تقنيات التسلسل من الجيل التالي (NGS) بدقة تفوق 99.9% وفقًا لمعايير الآيزو 9001:2015. تشمل الخدمة سحب عينات منزلية بمستوى المستشفى عبر النقل المبرد المعتمد، واستشارة هاتفية بعد ظهور النتائج، والتحقق المباشر من التأمين عبر الواتساب. تعمل المنظومة وفقًا للمرسوم بقانون اتحادي رقم 41 لسنة 2024 وقانون سلامة الطفل 2026 وقانون حماية البيانات الشخصية الإماراتي.
Premium Logistics
Hospital-Grade Home Collection (8 AM – 11 PM) · ISO Cold-Chain · VIP Phlebotomy
Clinical Guidance
Post-Test Telephonic Interpretation by DHA-licensed genetic counsellor
Insurance Direct Billing
WhatsApp verification: +971 54 548 8731
🔍 Test Overview
This Next-Generation Sequencing (NGS) test targets the full coding region of the TNFRSF11A gene, associated with autosomal recessive osteopetrosis type 7 – a severe bone-overgrowth disorder. In the UAE, it provides a definitive molecular diagnosis for families with suspected hereditary osteopetrosis, guiding early intervention and reproductive planning.
يستهدف هذا الاختبار التسلسل الكامل لجين TNFRSF11A المسبب لمرض تصلب العظام الوراثي المتنحي من النوع السابع، ويقدم تشخيصًا جزيئيًا قاطعًا للمرضى في الإمارات.
| Feature | Our Test (TNFRSF11A NGS) | Closest Alternative (Single-Gene Sanger) |
|---|---|---|
| Technology | Full gene NGS (Illumina® platform) with CNV detection | Bidirectional Sanger sequencing of selected exons |
| Diagnostic Yield | >99% for point mutations & deletions | ~85% (misses deep intronic & large rearrangements) |
| Turnaround Time | 3–4 Weeks | 5–7 Weeks (multi-step referral) |
| Regulatory Compliance | DHA 2026, ISO 9001:2015, Federal Decree-Law No. 41/2024 | Variable; often lacks UAE-specific chain-of-custody |
Clinical Experts & Specialist Panel
🩺 Dermatologist
Evaluates cutaneous and mucosal signs often presenting with skeletal pathology; coordinates multidisciplinary care for systemic autoinflammatory features linked to RANK pathway dysfunction.
🩺 Oncologist
Distinguishes benign osteopetrotic bone overgrowth from malignant primary/metastatic bone tumors; rules out osteosarcoma in atypical radiological presentations.
🏃 Sports Scientist
Advises on safe physical activity protocols, fracture-risk reduction, and bone-loading strategies for patients with abnormally dense but brittle bones.
🩺 Physician Insight & Safety Protocol
“I fully appreciate the emotional weight that accompanies a genetic for a rare bone disease. The TNFRSF11A result must be carefully correlated with clinical, radiological, and immunological findings—no single report dictates a management decision. As your consulting physician, I urge you to discuss the outcome with a qualified clinical geneticist before initiating any new therapy.”
— Dr. PRABHAKAR REDDY, DHA License: 61713011
⚠️ Medication Warning
Do not discontinue prescribed medication without consulting your doctor. Abrupt withdrawal of corticosteroids or bisphosphonates may precipitate severe metabolic complications.
🚨 Exclusion Criteria & Emergency Red Flags
- Exclusion: Individuals without a documented clinical suspicion of osteopetrosis (e.g., isolated osteopenia, no family history).
- Exclusion: Minors (<18 years) without signed parental consent as required by UAE Child Data Safety Law 2026 and DHA genomic consent form.
- Lab Rejection: Samples not collected in our ISO‑certified cold chain (hemolyzed, clotted, or non‑FTA preserved) will be rejected.
- ER Red Flags: Acute bone pain with neurological symptoms (vision/hearing loss, facial palsy), sudden pathologic fracture, or suspected malignant degeneration—proceed immediately to the nearest emergency department.
❓ Patient FAQ & Clinical Guidance
Q1: Why is NGS superior for detecting TNFRSF11A mutations compared to older tests?
Snippet: Our NGS assay reads every exon of the TNFRSF11A gene with deep coverage, identifying single‑nucleotide variants, small insertions/deletions, and copy‑number changes that Sanger misses.
Conventional Sanger sequencing often sequences only the most common mutation hotspots, risking false‑negative results in atypical phenotypes. NGS, coupled with our bioinformatics pipeline aligned to 2026 DHA genomic reporting standards, ensures comprehensive detection and is the gold standard for autosomal recessive osteopetrosis type 7 diagnosis.
س2: هل يمكن إجراء هذا التحليل للأطفال القصر في الإمارات؟
ملخص: نعم، بشرط توقيع الوالدين على استمارة الموافقة الجينية وفقًا لقانون سلامة الطفل 2026.
يتطلب الاختبار للقُصَّر موافقة كتابية من كلا الوالدين أو الوصي القانوني بعد جلسة استشارة وراثية موثقة. يُطبَّق قانون البيانات الجينية للأطفال الصادر عن هيئة الصحة بدبي ويضمن حماية المعلومات الوراثية. يتم جمع العينة بأقل تدخل جراحي عبر وخز الكعب أو سحب وريدي بسيط داخل وحدة منزلية معقمة.
Q3: How does the ISO‑certified cold chain and home collection work?
Snippet: A certified phlebotomist arrives with a temperature‑monitored transport box, collects either whole blood, extracted DNA, or a single drop of blood on an FTA card.
Our logistics comply with ISO 9001:2015 and UAE PDPL. The FTA card option stabilises DNA at ambient temperature and is ideal for remote locations. Samples are tracked via barcode from your doorstep to our DHA‑licensed laboratory (License: 9834453), with real‑time status updates shared via WhatsApp. All personnel undergo annual competency assessments.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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