Test Price
2,800 AED✅ Home Collection Available
TAC3 Gene Hypogonadotropic Hypogonadism Type 10 Genetic Test | 2800 AED
Executive Summary & Core Metrics
Clinical Assurance & Service Guarantees
The TAC3 gene sequencing test at DNA Labs UAE provides definitive molecular diagnosis for hypogonadotropic hypogonadism type 10, delivering 99.9% diagnostic sensitivity through ISO 9001:2015 accredited Next-Generation Sequencing with orthogonal confirmation of all pathogenic variants. This test is conducted under DHA Facility License 1143 at our Dubai Healthcare City laboratory.
- Diagnostic Accuracy Guarantee: 99.9% sensitivity via NGS with >100x mean read depth coverage and orthogonal Sanger confirmation of all clinically significant variants.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM across all UAE emirates.
- Clinical Guidance: Complimentary telephonic post-test consultation with a DHA-licensed Consultant Medical Genetics for result interpretation and genetic counselling referral.
- Insurance & Billing: Direct billing verification and pre-approval facilitation available via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This comprehensive genetic test utilizes Next-Generation Sequencing to analyze the entire coding and flanking intronic regions of the TAC3 gene, which encodes neurokinin B, a critical signaling molecule in the gonadotropin-releasing hormone (GnRH) neuronal network. Pathogenic variants in TAC3 cause normosmic or anosmic hypogonadotropic hypogonadism type 10, a condition presenting with delayed puberty, infertility, and low serum gonadotropins. The test distinguishes isolated GnRH deficiency from structural pituitary lesions and provides essential molecular confirmation for targeted hormone replacement therapy and family genetic counselling.
| Clinical Utility Parameter | Our Test (DHA-Compliant) | Closest Alternative (Single-Gene Sanger) |
|---|---|---|
| Technological Precision | NGS with >100x Mean Read Depth Coverage across all coding exons and intron-exon boundaries | Sanger Sequencing (limited to coding exons only, misses deep intronic variants and CNVs) |
| Variant Detection Spectrum | Full gene analysis including SNVs, indels, and CNVs via validated library preparation with LC-MS/MS quality control | Targeted mutation analysis only; misses novel pathogenic variants and structural rearrangements |
| Diagnostic Turnaround Time | 21–28 calendar days with expedited reporting for urgent clinical decisions | 6–8 weeks via standard commercial reference laboratories |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Interpretation of a TAC3 genetic report requires careful clinical correlation with GnRH stimulation testing and anterior pituitary imaging. A confirmed pathogenic variant in TAC3 establishes the molecular etiology of congenital hypogonadotropic hypogonadism type 10, but does not independently determine the therapeutic approach for sex steroid induction or fertility management. A negative result in a patient with a classic Kallmann syndrome phenotype necessitates expansion of genomic evaluation to include ANOS1, FGFR1, PROK2, and PROKR2 genes, reinforcing the diagnostic advantage of comprehensive NGS panels over single-gene analysis.
Critical Medication & Safety Advisory
Hormonal Therapy Precautions
Do not discontinue, alter, or initiate any prescribed hormonal therapy including testosterone, estradiol, or gonadotropin preparations without direct consultation with your endocrinologist. Abrupt cessation of sex steroid therapy can precipitate acute adrenal insufficiency in patients with concurrent ACTH deficiency, severe mood dysregulation, or significant bone mineral density loss. This genetic test does not replace ongoing endocrine monitoring.
Exclusion Criteria & Emergency Red Flags
Sample Rejection and Safety Parameters
- Sample Rejection Triggers: Hemolyzed whole blood specimen, incorrect anticoagulant (EDTA tubes only), FTA card with insufficient dried blood spot diameter less than 3 mm, or extracted DNA with A260/A280 ratio below 1.6.
- Emergency Red Flags (Direct to ER): This test is elective. Seek immediate emergency care if the patient experiences sudden testicular torsion-like pain, severe adrenal crisis symptoms (hypotension, refractory hypoglycemia, loss of consciousness), or acute scrotal swelling with fever.
- Minors Protocol: Testing on individuals under 18 years requires documented informed consent from a legal guardian and a formal clinical genetics referral. All genetic testing on minors follows UAE Federal Decree-Law No. 4 of 2016 on Medical Liability and PDPL data protection standards.
Patient FAQ & Clinical Guidance
1. If my TAC3 gene test is negative, does it completely rule out all forms of hypogonadotropic hypogonadism?
A negative TAC3 gene result definitively excludes only type 10 congenital hypogonadotropic hypogonadism. However, there are more than 30 other genes associated with this condition, including ANOS1, FGFR1, GNRHR, PROK2, and CHD7. A negative single-gene test in the presence of strong clinical features such as anosmia, cryptorchidism, or micropenis warrants evaluation with a comprehensive NGS panel covering all known loci. Your consultant geneticist will guide the appropriate stepwise testing strategy based on your specific phenotype and family history.
2. Why does the laboratory require a genetic counselling session before proceeding with this DNA test?
Pre-test genetic counselling is mandatory to establish the autosomal recessive inheritance pattern of TAC3-related hypogonadotropic hypogonadism, identify at-risk family members who may benefit from carrier testing, and obtain fully informed consent regarding potential secondary findings that NGS technology may uncover. This session ensures that you understand the implications of both positive and negative results, including reproductive risks, before specimen collection proceeds. The session is conducted by our DHA-licensed Consultant Medical Genetics at no additional charge.
3. How long does it take to receive the TAC3 genetic results and how are they delivered in the UAE?
The complete clinical report with full variant interpretation, pathogenicity classification according to ACMG guidelines, and clinical recommendations is delivered via encrypted email within 21 to 28 calendar days from sample receipt. Delivery includes a mandatory telephonic consultation from our DHA-licensed clinical genetics team to explain the results, discuss reproductive implications, and coordinate any recommended family cascade testing or specialist referrals. Physical copies are available upon request at our Dubai Healthcare City laboratory.
UAE Regulatory & Data Privacy Adherence
Legal Compliance & Data Protection Standards
DNA Labs UAE operates under DHA Facility License 1143 and strictly adheres to all applicable UAE federal data protection and health information security regulations. All genetic data generated from this test is processed, stored, and transmitted in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical procedures and patient consent protocols follow the requirements of Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic information is encrypted at rest and in transit, accessed only by authorized clinical personnel, and never shared with third parties without your explicit written consent. You retain the right to access your data, request correction, and withdraw consent for processing at any time through our data protection officer.
Clinical & Logistical Metadata
| Test Name | TAC3 Gene Hypogonadotropic Hypogonadism Type 10 Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 21–28 Calendar Days |
| Sample Type / Matrix | Whole Blood (EDTA) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM – 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) with >100x Mean Read Depth Coverage, Orthogonal Sanger Confirmation |
| ICD-10-CM Code | E23.0 |
| LOINC Code | 21622-7 |
| DHA Facility License & Laboratory Address | License 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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