Test Price
2,800 AED✅ Home Collection Available
SLX4 Gene Fanconi Anemia Type P Genetic Test in UAE | Next-Generation Sequencing (NGS) | DNA Labs UAE
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% analytical sensitivity for SLX4 pathogenic variants via ISO 9001:2015 accredited processing pipeline.
- Specimen Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily 8 AM – 11 PM).
- Clinical Follow-Up: Telephonic post-test result interpretation by DHA-licensed genetics specialists.
- Insurance & Billing: Direct billing verification via WhatsApp +971 54 548 8731.
- Turnaround Time: Results delivered within 3 to 4 weeks from sample receipt.
Test Overview & Methodology
The SLX4 Gene Fanconi Anemia Type P Genetic Test employs next‑generation sequencing (NGS) to interrogate the entire coding region and splice junctions of the SLX4 gene. This assay detects single‑nucleotide variants, small insertion‑deletion mutations, and copy‑number aberrations that underlie Fanconi anemia complementation group P — a hereditary bone marrow failure syndrome with elevated risk for acute myeloid leukemia and solid tumours. Definitive molecular diagnosis enables precise treatment planning, including haematopoietic stem cell transplantation optimisation, cancer surveillance scheduling, and informed family counselling.
| Feature | Our NGS Test | Closest Alternative (DEB Chromosomal Breakage) |
|---|---|---|
| Precision & Sensitivity | >99.9% for SLX4 variants; full gene sequencing & deletion/duplication analysis | ~85% sensitivity; functional assay does not identify specific gene |
| Methodology | NGS on Illumina platform | Cytogenetic diepoxybutane (DEB) induced breakage |
| Turnaround Time | 3 to 4 Weeks | 5–7 days |
| Clinical Utility | Definitive subtype classification, carrier testing, family planning | Screening for Fanconi anemia; cannot subtype |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403) states: “An SLX4 pathogenic variant carries specific implications for bone marrow surveillance and cancer risk stratification. The NGS result should always be correlated with complete blood counts, bone marrow morphology, and chromosomal breakage studies before initiating therapy. Genetic counselling for at‑risk relatives is equally essential.”
Clinical Advisory
⚠️ Important Pre-Test Guidance
Never discontinue or adjust prescribed medications, including any haematologic supportive therapy, without direct consultation with your treating physician. The genetic test result is one component of a comprehensive diagnostic work‑up and does not replace clinical judgment.
Exclusion Criteria & ER Red Flags
- Minors (under 18 years): Testing requires documented parental or legal guardian consent in compliance with UAE federal regulations.
- Inadequate sample quality: Haemolysed blood or insufficient DNA concentration will necessitate recollection.
- Emergency warning signs: If you develop spontaneous bruising, petechiae, severe fatigue with fever, or signs of active bleeding, seek emergency medical care immediately regardless of your test schedule.
Patient FAQ & Clinical Guidance
1. What is the SLX4 gene test and who should consider it?
This NGS-based test analyses the complete SLX4 gene coding sequence for mutations that cause Fanconi anemia type P. It is indicated for individuals with unexplained bone marrow failure, a family history of Fanconi anemia, or clinical features suggestive of the condition. The test provides a definitive molecular diagnosis that guides treatment and surveillance strategies.
2. How should I interpret a negative result from this genetic test?
A negative NGS result with >99.9% analytical sensitivity effectively excludes SLX4-associated Fanconi anemia type P. However, it does not rule out other Fanconi anemia complementation groups or acquired causes of marrow failure. Your physician may recommend additional gene panel testing or chromosomal breakage analysis if clinical suspicion remains high.
3. What steps follow a positive SLX4 mutation result?
A positive result requires prompt referral to a haematologist for bone marrow surveillance and discussion of curative options such as haematopoietic stem cell transplantation. Genetic counselling for cascade testing of first‑degree relatives is strongly advised to identify at‑risk family members who may benefit from early intervention.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework
DNA Labs UAE operates under DHA Facility License No. 1143 and adheres to the highest data protection and health information governance standards as mandated by:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) — governing the collection, processing, and storage of personal health data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields — regulating digital health records and telemedicine practices.
- Federal Decree-Law No. 4 of 2016 on Medical Liability — ensuring clinical safety and informed patient consent across all diagnostic procedures.
All genetic data is encrypted, access‑controlled, and retained only for the duration required by applicable UAE health regulations.
Clinical & Logistical Metadata
| Test Name | SLX4 Gene Fanconi Anemia Type P Genetic Test (Next-Generation Sequencing) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL in EDTA tube); VIP Mobile Phlebotomy & Cold-Chain Home Collection available daily 8 AM – 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina platform with deletion/duplication analysis |
| ICD-10-CM Code | D61.09 (Other constitutional aplastic anemia) |
| LOINC Code | 93344-3 (SLX4 gene full sequencing) |
| DHA Facility License & Laboratory Address | Facility License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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