Test Price
2,800 AED✅ Home Collection Available
SHBG Gene (Androgen-Binding Protein Deficiency) Genetic Test
Executive Summary & Core Metrics
- 🔬 Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO‑accredited NGS processing, validated with Sanger confirmation and modern LC‑MS/MS comparators.
- 🏥 Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily from 8 AM to 11 PM, UAE‑wide).
- 🩺 Clinical Guidance: Free pre‑test genetic counselling and telephonic post‑test consultation with a consultant medical geneticist to interpret results in the context of your hormone profile.
- 💳 Insurance: Direct billing verification via WhatsApp at +971 54 548 8731 — we confirm coverage before sample collection.
Test Overview & Methodology
The SHBG gene NGS test sequences all coding regions of the sex hormone‑binding globulin gene to detect pathogenic variants causing androgen‑binding protein deficiency. This hereditary condition alters free testosterone and estradiol levels, impacting fertility, metabolic health, and hormone‑sensitive tissues. Results are delivered in 10–14 business days using next‑generation sequencing at a DHA‑licensed genomic facility.
| Feature | Our Test – SHBG NGS (DNA) | Closest Alternative – Serum SHBG Immunoassay |
|---|---|---|
| Precision / Method | Full gene sequencing (NGS), detection of single‑nucleotide variants, indels | Immunometric assay (measures protein level) |
| Clinical Depth | Identifies inherited mutations – basis for personalised hormone optimisation | Quantifies circulating SHBG; does not reveal genetic aetiology |
| Speed (TAT) | 10–14 business days | 1–2 days |
| UAE Price | 2,800 AED | ~400–600 AED |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403) notes: “This test reveals the genetic blueprint behind SHBG production. It does not replace measuring serum SHBG or free hormones. I always pair it with a full endocrine panel and reproductive history. A positive result guides tailored hormone management, while a negative result still demands clinical correlation. Genetic information is one piece of your health mosaic.”
Medication Advisory
⚠️ Important: Do not discontinue prescribed medication without consulting your doctor. Abrupt cessation of androgen therapies, oral contraceptives, or thyroid hormones can provoke serious metabolic disturbances. Always discuss any planned changes with your endocrinologist.
Exclusion Criteria & Red Flags
🛡️ Safety Precautions
- Exclusion: Minors (<18) without court‑appointed guardian consent; individuals unable to understand genetic counselling in Arabic or English.
- Contraindication: Active severe infection or febrile illness may delay sample collection.
- Seek Emergency Care if: You experience sudden severe testicular or pelvic pain, acute visual changes, or signs of adrenal crisis after discontinuing prescribed steroids.
- Post‑test red flag: A pathogenic variant combined with rapidly progressing virilisation requires immediate endocrinology consultation.
Patient FAQ & Clinical Guidance
1. What exactly does the SHBG gene test detect, and how reliable is it?
The SHBG gene Genetic Test detects androgen‑binding protein deficiency mutations by sequencing all coding regions with 99.9% diagnostic sensitivity. It identifies missense, nonsense, and splice‑site variants that impair SHBG production and binding capacity. Our validated NGS pipeline achieves coverage depth >100x, and all pathogenic calls are confirmed by Sanger sequencing before reporting.
2. Who should consider this genetic test in the UAE?
Patients with unexplained hyper- or hypogonadotropic hypogonadism, infertility, or discordant SHBG levels despite normal pituitary function should consider testing. It is also indicated for families with a history of androgen insensitivity, early‑onset metabolic syndrome, or for individuals planning evidence‑based hormone optimisation. A pre‑test genetic counselling session is mandatory to map the pedigree and understand inheritance.
3. How are my genetic data protected, and what UAE laws apply?
Your genomic data is encrypted, stored on UAE‑sovereign servers, and never shared without your explicit consent as mandated by UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL). The test also complies with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, and clinical safety is governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. Our laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139).
UAE Regulatory & Data Privacy Adherence
Your privacy and sample integrity are protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 for health ICT. The diagnostic procedure adheres to Federal Decree-Law No. 4 of 2016 on Medical Liability. Your data is never shared with third parties without written consent. Genomic results are stored on encrypted UAE‑based servers and can be accessed only by the requesting physician and the patient after identity verification.
Clinical & Logistical Metadata
| Test Name | SHBG Gene (Androgen-Binding Protein Deficiency) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 10–14 business days |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card. Cold‑chain transport required. |
| Methodology Used | Next‑Generation Sequencing (NGS) – Illumina platform, >100x coverage depth, Sanger confirmation |
| ICD-10-CM Code | Z13.81 (Encounter for screening for genetic and chromosomal anomalies) |
| LOINC Code | 94762-0 (SHBG gene full sequencing) |
| DHA Facility License & Laboratory Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians