Test Price
2,800 AED✅ Home Collection Available
SH2D1A Gene (X-Linked Lymphoproliferative Syndrome Type 1) Genetic Test in the UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
Summary: This Next-Generation Sequencing (NGS) test provides full-gene coverage of the SH2D1A locus with a guaranteed diagnostic sensitivity of 99.9% through ISO-accredited processing. It is the definitive molecular assay for confirming X-linked lymphoproliferative syndrome type 1 (XLP1).
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This test employs Next-Generation Sequencing (NGS) to fully analyze the SH2D1A gene, detecting pathogenic variants responsible for X-linked lymphoproliferative syndrome type 1 (XLP1), a rare immunodeficiency predisposing to hemophagocytic lymphohistiocytosis and lymphoma. Comprehensive coverage of all coding exons and flanking splice-site regions ensures detection of point mutations, small insertions, and deletions. Clinical correlation with family history, immune function, and lymphoproliferation signs remains essential for definitive diagnosis.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Diagnostic Sensitivity | 99.9% | ~95% for targeted regions |
| Gene Coverage | Full coding region and splice sites | Selected exons only |
| Turnaround Time | 3–4 weeks | 4–6 weeks |
| Price | 2,800 AED | Varies |
Physician Insight & Safety Protocols
"As a Consultant Medical Geneticist, I recommend the SH2D1A NGS test as the gold standard for confirming XLP1 in patients with unexplained HLH, lymphoma susceptibility, or family histories suggestive of X-linked immunodeficiency. A negative result does not rule out alternative genetic etiologies such as XIAP deficiency, and all findings must be correlated with the patient's full clinical picture and immune workup. Early molecular diagnosis enables life-saving surveillance for lymphoma and timely referral for hematopoietic stem cell transplantation." – Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Critical Advisory for Patients
Medication Safety Notice
Do not discontinue any prescribed immunosuppressive or immunomodulatory therapy without direct consultation with your treating specialist. A negative genetic result for SH2D1A does not exclude XLP1 or other immunodeficiency syndromes. All medication adjustments must be supervised by the managing hematologist or immunologist.
Essential Safety and Exclusion Criteria
Patient Suitability and Emergency Red Flags
- Not intended for standalone prenatal diagnosis; requires comprehensive genetic counseling and confirmatory testing.
- Recent blood transfusion within the prior two weeks may cause sample rejection due to donor DNA interference; defer collection until clearance is confirmed.
- Emergency red flags: High fever, severe cytopenias, hepatosplenomegaly, or clinical signs of hemophagocytic lymphohistiocytosis mandate immediate hospital evaluation. Do not delay emergency care while awaiting test results.
Patient FAQ & Clinical Guidance
1. What does the SH2D1A NGS test diagnose?
This test identifies pathogenic variants in the SH2D1A gene, confirming X-linked lymphoproliferative syndrome type 1, which causes severe immune dysregulation and increased risk of lymphoma. Early diagnosis through this molecular assay enables proactive surveillance and timely intervention.
2. How is the sample collected and what preparation is needed?
A standard peripheral blood draw, one drop of blood on an FTA card, or extracted DNA from a prior specimen can be used. No fasting or dietary preparation is required, but a detailed clinical history and a mandatory pre-test genetic counseling session must be completed before sample collection.
3. Will insurance cover this test and what is the turnaround time?
Most UAE health insurers cover medically indicated genetic testing for XLP1. Our team verifies your benefits directly via WhatsApp at +971 54 548 8731. Results are delivered within three to four weeks from sample receipt at our ISO-accredited laboratory.
4. What do my results mean and what follow-up is recommended?
A positive result confirms a pathogenic variant and indicates XLP1, requiring ongoing hematology and immunology follow-up. A negative result reduces but does not eliminate suspicion for XLP1; alternative genetic causes such as XIAP deficiency should be considered. All results include a post-test telephonic consultation with our genetics team to guide next steps.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance and Data Protection Framework
DNA Labs UAE operates under DHA Facility License Number 1143 and adheres strictly to all UAE federal data protection and health information regulations. Patient genetic data is processed and stored in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability. All laboratory procedures maintain ISO 9001:2015 certification, ensuring the highest standards of quality and confidentiality.
Clinical & Logistical Metadata
| Test Name | SH2D1A Gene (X-Linked Lymphoproliferative Syndrome Type 1) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood, FTA card, or extracted DNA; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) – full coding region and splice-site analysis |
| ICD-10-CM Code | D82.3 |
| LOINC Code | 81263-9 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab Branding: DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians