Test Price
2,800 AED✅ Home Collection Available
RNF216 Gene (Gordon Holmes Syndrome) Genetic Test in UAE – 2,800 AED
Executive Summary & Core Metrics
Executive Summary – 2,800 AED All‑Inclusive
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO‑Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic post‑test result interpretation by a DHA‑licensed clinician.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This Genetic Test analyses the entire coding region and exon‑intron boundaries of the RNF216 gene to confirm Gordon Holmes syndrome, a rare autosomal recessive neurodegenerative disorder.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next‑Generation Sequencing (NGS) | Sanger sequencing |
| Genomic Coverage | Complete coding region + splice sites | Targeted known mutation only |
| Turnaround Time | 3–4 Weeks | 2–3 Weeks |
| Diagnostic Yield | >99% against reference | ~95% for single variant |
| Price (AED) | 2,800 | ~2,400 |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh – Consultant Medical Genetics – DHA Registration ID: 9294403
“A positive RNF216 result must be correlated with clinical manifestations of progressive cerebellar ataxia, hypogonadotropic hypogonadism, and cognitive decline. Genetic counselling is essential before and after testing, as early identification can guide family planning and symptomatic management.”
Safety Advisory
- ER Red Flags (seek immediate care): Acute neurological deterioration, severe unexplained headache with vision loss, new‑onset seizures, or loss of consciousness.
- Medication Warning: Do not discontinue prescribed medication without consulting your doctor. This test does not replace neurologic follow‑up.
- Minors require explicit consent from a legal guardian in compliance with applicable UAE regulations.
Exclusion Criteria
- Inability to provide informed consent.
- Severe uncorrected coagulopathy (for blood draw).
- Febrile illness on day of collection.
Patient FAQ & Clinical Guidance
1. What is the purpose of this RNF216 gene test?
This test identifies pathogenic variants in the RNF216 gene to confirm Gordon Holmes syndrome diagnosis in patients with progressive neurological decline and hypogonadism. It aids in distinguishing the condition from other ataxia syndromes and provides crucial information for family risk assessment and reproductive options.
2. Which sample types are accepted and how is the collection done?
We accept whole blood, extracted DNA, or a dried blood spot on FTA card, allowing flexible home collection with cold‑chain transport. A certified phlebotomist arrives at your doorstep (8 AM–11 PM) and follows strict ISO‑certified protocols; the sample is immediately stabilized and shipped to our central lab.
3. How long does it take to receive results and what support is provided?
Results are typically reported within 3 to 4 weeks, with genetic counselling available upon request through our telephonic post‑test guidance. A board‑certified genetic counsellor will explain the findings, interpret variant significance, and discuss implications for family members.
UAE Regulatory & Data Privacy Adherence
Our services fully comply with:
- UAE Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- ISO 9001:2015 Certification (Cert# INT/EGQ/2509DA/3139).
- DHA Facility License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Laboratory: DNA Labs UAE.
Clinical & Logistical Metadata
| Test Name | RNF216 Gene (Gordon Holmes Syndrome) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole blood (peripheral), extracted DNA, or dried blood spot on FTA card |
| Methodology Used | Next‑Generation Sequencing (NGS) |
| ICD-10-CM Code | G31.8, E23.3, Z13.79 |
| LOINC Code | 101649-4 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians