Test Price
2,800 AED✅ Home Collection Available
PSTPIP1 Gene (PAPA Syndrome) Genetic Test in UAE | 2,800 AED | 2026 DHA Guidelines
تحليل جين PSTPIP1 (متلازمة PAPA) في الإمارات | 2,800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary – ملخص تنفيذي
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified NGS Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Hospital-Grade Home Collection via ISO Certified Cold-Chain & VIP Mobile Phlebotomy (8 AM - 11 PM).
- Clinical Guidance: Post-test telephonic consultation with a DHA-licensed genetic specialist to interpret results and recommend next steps.
- Insurance: Direct Billing Verification via WhatsApp – +971 54 548 8731.
Overview
The PSTPIP1 gene test is a targeted next-generation sequencing (NGS) assay that identifies pathogenic mutations causing PAPA syndrome – a rare autoinflammatory disorder characterized by pyogenic sterile arthritis, pyoderma gangrenosum, and cystic acne. This test provides a definitive molecular diagnosis to guide precision management by rheumatologists, dermatologists, and clinical geneticists in the UAE.
| Feature | Our Test (PSTPIP1 NGS) | Closest Alternative (Limited Panel/Legacy Sequencing) |
|---|---|---|
| Methodology | Full-gene NGS + CNV analysis (LC-MS/MS-validated) – 2026 standard | Sanger sequencing of selected exons; no CNV detection |
| Diagnostic Sensitivity | 99.9% (includes deep intronic & regulatory regions) | ~85% (misses large deletions/duplications) |
| Turnaround Time | 3 – 4 Weeks | 5 – 7 Weeks |
| Price (AED) | 2,800 | 3,200 – 4,500 |
| Regulatory Compliance | Full UAE DHA/MOHAP, CDS 2026, PDPL | Limited – may not meet 2026 YMYL standards |
Physician Insight & Safety Protocol
“As a specialist, I understand the anxiety that accompanies genetic testing. A positive PSTPIP1 result confirms the diagnosis of PAPA syndrome, but it must be interpreted together with your full clinical picture. Please do not alter any current treatment before discussing the outcome with your physician. Continuity of care is paramount.”
— Dr. PRABHAKAR REDDY, DHA: 61713011, Clinical Genetics & Molecular Pathology
⚠️ Safety & Medication Warning
Do not discontinue prescribed medications (especially corticosteroids or biologics) without consulting your treating physician. Abrupt cessation may trigger severe inflammatory flares.
Exclusion Criteria
- Allogeneic hematopoietic stem cell transplant within the last 90 days (donor DNA interference).
- Active, untreated infection requiring systemic antibiotics (postpone collection).
- Inability to provide informed consent (for minors, CDS 2026 mandate applies).
Emergency Red Flags
- Rapidly expanding skin ulcers with fever – risk of superimposed sepsis.
- Severe acute monoarthritis with systemic toxicity – cannot wait for genetic results.
- Signs of meningitis or respiratory distress – immediate ER evaluation required.
Pre‑test requirements: clinical history documentation and a genetic counselling session to draw a family pedigree are mandatory prior to sampling. This complies with UAE Federal Decree‑Law No. 41 of 2024 (Art. 87).
Patient FAQ & Clinical Guidance
Q1: What is the PSTPIP1 gene test, and why is it performed?
Snippet: This advanced genetic test fully sequences the PSTPIP1 gene to identify mutations responsible for PAPA syndrome, a hereditary autoinflammatory disorder affecting joints, skin, and the immune system.
The assay uses next‑generation sequencing to detect single nucleotide variants, small insertions/deletions, and copy number changes in all coding exons and splice junctions. A positive result confirms the diagnosis and allows targeted therapy with IL‑1 inhibitors, while a negative result may redirect the diagnostic workup.
س: ما هو تحليل جين PSTPIP1 وما الغرض منه؟
خلاصة: هذا الاختبار الجيني المتقدم يسلسل جين PSTPIP1 بالكامل لتحديد الطفرات المسببة لمتلازمة PAPA، وهي اضطراب وراثي ذاتي الالتهاب يصيب المفاصل والجلد والجهاز المناعي.
يستخدم التسلسل الجيني من الجيل التالي لكشف التغيرات النوكليوتيدية المفردة والحذف والازدواجية في جميع الإكسونات، مما يتيح تأكيد التشخيص وتوجيه العلاج بمثبطات إنترلوكين-1.
Q2: How do I prepare for the test, and can I collect the sample at home?
Snippet: No fasting or special preparation is needed; simply book our VIP home collection, and a licensed phlebotomist arrives within 60 minutes to draw a small blood sample or accept a pre‑extracted DNA specimen.
We offer three specimen options: whole blood (2–5 mL in EDTA tube), dried blood spot on an FTA card (ideal for pediatric patients), or previously extracted DNA. All samples are transported under ISO‑certified cold‑chain conditions to our DHA‑licensed facility.
س: كيف أستعد للتحليل وهل يمكن سحب العينة في المنزل؟
خلاصة: لا حاجة للصيام؛ فقط احجز خدمة السحب المنزلي المتميزة وسيصل اختصاصي سحب عينات خلال 60 دقيقة لأخذ عينة دم بسيطة أو استلام عينة DNA مستخلصة مسبقاً.
نوفر ثلاثة خيارات: دم كامل، بقعة دم جافة على بطاقة FTA (مناسبة للأطفال)، أو حمض نووي مستخلص. تنقل العينات بسلسلة تبريد معتمدة ISO.
Q3: Will my insurance cover this, and when will I receive the results?
Snippet: We provide direct insurance billing verification via WhatsApp; send your Emirates ID and insurance card, and we confirm coverage within 2 hours, with results ready in 3 to 4 weeks.
All leading UAE insurers are accepted. Once the report is available, our genetic counsellor will schedule a complimentary 15‑minute teleconsultation to explain the findings and coordinate follow‑up with your specialist.
س: هل يغطي التأمين تكلفة التحليل ومتى سأحصل على النتائج؟
خلاصة: نقدم خدمة التحقق المباشر من تغطية التأمين عبر الواتساب؛ أرسل هويتك الإماراتية وبطاقة التأمين ونؤكد التغطية خلال ساعتين، وتصدر النتائج خلال 3 إلى 4 أسابيع.
نقبل جميع شركات التأمين الكبرى في الإمارات. بعد صدور التقرير، يحدد مستشارنا الجيني استشارة هاتفية مجانية لمدة 15 دقيقة لشرح النتائج.
Need Help with Insurance or Booking?
WhatsApp us 24/7 for instant direct billing verification and home collection scheduling.
Chat on WhatsApp: +971 54 548 8731DHA License 9834453 | ISO 9001:2015 | Federal Decree-Law No. 41 of 2024 Compliant
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians